Incidental Mutation 'R0947:Trim5'
ID 81664
Institutional Source Beutler Lab
Gene Symbol Trim5
Ensembl Gene ENSMUSG00000060441
Gene Name tripartite motif-containing 5
Synonyms
MMRRC Submission 039086-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.061) question?
Stock # R0947 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 103912593-103937301 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 103914958 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 370 (D370E)
Ref Sequence ENSEMBL: ENSMUSP00000095781 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051795] [ENSMUST00000060315] [ENSMUST00000098179] [ENSMUST00000106848] [ENSMUST00000106849]
AlphaFold E9PV98
Predicted Effect probably damaging
Transcript: ENSMUST00000051795
AA Change: D370E

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000050084
Gene: ENSMUSG00000060441
AA Change: D370E

DomainStartEndE-ValueType
RING 15 58 3.64e-7 SMART
BBOX 91 132 4.83e-12 SMART
coiled coil region 172 232 N/A INTRINSIC
Pfam:SPRY 349 485 9.2e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000060315
SMART Domains Protein: ENSMUSP00000055058
Gene: ENSMUSG00000056144

DomainStartEndE-ValueType
RING 15 58 6.79e-7 SMART
BBOX 91 132 1.08e-9 SMART
coiled coil region 194 238 N/A INTRINSIC
Blast:PRY 299 343 2e-21 BLAST
Pfam:SPRY 347 474 1e-12 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000098179
AA Change: D370E

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000095781
Gene: ENSMUSG00000060441
AA Change: D370E

DomainStartEndE-ValueType
RING 15 58 3.64e-7 SMART
BBOX 91 132 4.83e-12 SMART
Pfam:SPRY 351 493 1.6e-13 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000106848
SMART Domains Protein: ENSMUSP00000102461
Gene: ENSMUSG00000056144

DomainStartEndE-ValueType
RING 15 58 6.79e-7 SMART
BBOX 91 132 1.08e-9 SMART
coiled coil region 194 238 N/A INTRINSIC
Blast:PRY 299 343 2e-21 BLAST
Pfam:SPRY 345 484 6.5e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000106849
SMART Domains Protein: ENSMUSP00000102462
Gene: ENSMUSG00000056144

DomainStartEndE-ValueType
RING 15 58 6.79e-7 SMART
BBOX 91 132 1.08e-9 SMART
coiled coil region 194 238 N/A INTRINSIC
Blast:PRY 299 343 2e-21 BLAST
Pfam:SPRY 345 484 6.5e-21 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000158033
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217156
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.2%
  • 10x: 95.4%
  • 20x: 89.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aldh7a1 A T 18: 56,693,910 (GRCm39) probably null Het
Atm A G 9: 53,415,392 (GRCm39) V833A probably benign Het
Atp6v1b1 A T 6: 83,730,814 (GRCm39) I180F probably damaging Het
Cwf19l2 T C 9: 3,421,286 (GRCm39) S188P probably benign Het
Gdpd1 T G 11: 86,928,707 (GRCm39) E240D probably benign Het
Hsh2d G A 8: 72,954,304 (GRCm39) D229N probably benign Het
Htt T C 5: 35,056,268 (GRCm39) S2681P probably damaging Het
Itgad A G 7: 127,774,865 (GRCm39) D40G probably benign Het
Krt18 A G 15: 101,939,163 (GRCm39) Y249C possibly damaging Het
Lrp2 G T 2: 69,318,182 (GRCm39) P2090T probably damaging Het
Lrrc32 A G 7: 98,148,090 (GRCm39) D290G probably benign Het
Man1a A T 10: 53,809,619 (GRCm39) Y486* probably null Het
Mcm9 CCTGTCCCTGCTGTCCCTGCTGTCCCTGCTGTCCCTGCTGTCC CCTGTCCCTGCTGTCCCTGCTGTCCCTGCTGTCC 10: 53,413,597 (GRCm39) probably benign Het
Nin A T 12: 70,107,960 (GRCm39) C211S probably damaging Het
Npat A C 9: 53,481,624 (GRCm39) I1111L probably benign Het
Or5p79 A G 7: 108,221,879 (GRCm39) I287V probably benign Het
Or9i1b T A 19: 13,896,535 (GRCm39) H50Q probably benign Het
Pbx1 A G 1: 168,030,935 (GRCm39) S228P probably damaging Het
Pcsk7 G T 9: 45,822,470 (GRCm39) R230L probably damaging Het
Prom2 G T 2: 127,380,183 (GRCm39) Q350K possibly damaging Het
Racgap1 C T 15: 99,522,195 (GRCm39) A458T possibly damaging Het
Rsf1 T A 7: 97,318,985 (GRCm39) C912S probably damaging Het
Setd2 G A 9: 110,377,579 (GRCm39) E465K possibly damaging Het
Sgk2 T A 2: 162,848,758 (GRCm39) D269E probably benign Het
Spsb1 T C 4: 149,991,536 (GRCm39) T11A probably benign Het
Tln2 A T 9: 67,203,095 (GRCm39) S509T probably benign Het
Ttn T A 2: 76,715,574 (GRCm39) probably benign Het
Ubr2 C A 17: 47,252,038 (GRCm39) G1501C probably damaging Het
Ugcg C T 4: 59,207,798 (GRCm39) P46S probably benign Het
Vmn2r93 A T 17: 18,524,343 (GRCm39) R112S probably benign Het
Vps26b T C 9: 26,924,077 (GRCm39) Y222C probably damaging Het
Wdr64 T A 1: 175,603,315 (GRCm39) Y198N probably benign Het
Xrn1 A T 9: 95,880,316 (GRCm39) K752I possibly damaging Het
Zbtb14 C A 17: 69,695,497 (GRCm39) F398L probably damaging Het
Zfp386 T C 12: 116,023,398 (GRCm39) I372T probably benign Het
Zfp804a T C 2: 82,089,062 (GRCm39) Y964H possibly damaging Het
Other mutations in Trim5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01702:Trim5 APN 7 103,928,638 (GRCm39) missense probably damaging 1.00
IGL02165:Trim5 APN 7 103,928,566 (GRCm39) missense probably damaging 1.00
IGL02576:Trim5 APN 7 103,927,624 (GRCm39) missense probably damaging 0.97
IGL02660:Trim5 APN 7 103,915,425 (GRCm39) missense probably damaging 0.96
IGL02732:Trim5 APN 7 103,927,672 (GRCm39) missense probably benign 0.02
R0278:Trim5 UTSW 7 103,928,882 (GRCm39) missense probably benign 0.00
R0373:Trim5 UTSW 7 103,914,891 (GRCm39) missense probably benign 0.00
R0508:Trim5 UTSW 7 103,914,811 (GRCm39) missense probably null 0.98
R0840:Trim5 UTSW 7 103,914,978 (GRCm39) missense probably damaging 1.00
R1432:Trim5 UTSW 7 103,928,728 (GRCm39) missense probably benign
R1432:Trim5 UTSW 7 103,928,726 (GRCm39) missense probably benign 0.04
R1770:Trim5 UTSW 7 103,925,868 (GRCm39) missense probably damaging 1.00
R1782:Trim5 UTSW 7 103,915,023 (GRCm39) splice site probably null
R1988:Trim5 UTSW 7 103,914,828 (GRCm39) missense probably damaging 0.99
R2140:Trim5 UTSW 7 103,925,998 (GRCm39) nonsense probably null
R3110:Trim5 UTSW 7 103,928,845 (GRCm39) missense probably damaging 1.00
R3112:Trim5 UTSW 7 103,928,845 (GRCm39) missense probably damaging 1.00
R3893:Trim5 UTSW 7 103,926,042 (GRCm39) missense probably damaging 0.98
R3948:Trim5 UTSW 7 103,915,727 (GRCm39) nonsense probably null
R4114:Trim5 UTSW 7 103,914,947 (GRCm39) missense probably damaging 0.99
R4249:Trim5 UTSW 7 103,926,022 (GRCm39) missense possibly damaging 0.83
R4352:Trim5 UTSW 7 103,926,015 (GRCm39) missense probably damaging 1.00
R4595:Trim5 UTSW 7 103,914,639 (GRCm39) missense probably damaging 1.00
R5057:Trim5 UTSW 7 103,914,630 (GRCm39) missense probably damaging 1.00
R5583:Trim5 UTSW 7 103,926,042 (GRCm39) missense probably damaging 0.98
R5861:Trim5 UTSW 7 103,928,728 (GRCm39) missense probably benign
R5861:Trim5 UTSW 7 103,928,726 (GRCm39) missense probably benign 0.04
R7027:Trim5 UTSW 7 103,914,875 (GRCm39) missense probably benign 0.00
R7078:Trim5 UTSW 7 103,927,681 (GRCm39) missense possibly damaging 0.85
R7150:Trim5 UTSW 7 103,926,017 (GRCm39) missense probably damaging 0.96
R7657:Trim5 UTSW 7 103,925,884 (GRCm39) missense possibly damaging 0.51
R7660:Trim5 UTSW 7 103,928,569 (GRCm39) missense probably damaging 1.00
R7737:Trim5 UTSW 7 103,928,771 (GRCm39) missense probably damaging 1.00
R7821:Trim5 UTSW 7 103,927,633 (GRCm39) missense probably benign 0.32
R7861:Trim5 UTSW 7 103,915,675 (GRCm39) critical splice donor site probably null
R8167:Trim5 UTSW 7 103,927,630 (GRCm39) missense probably damaging 0.99
R8220:Trim5 UTSW 7 103,926,033 (GRCm39) missense probably damaging 0.96
R8296:Trim5 UTSW 7 103,914,993 (GRCm39) missense probably damaging 1.00
R8555:Trim5 UTSW 7 103,927,330 (GRCm39) splice site probably null
Z1088:Trim5 UTSW 7 103,915,432 (GRCm39) missense possibly damaging 0.85
Predicted Primers PCR Primer
(F):5'- CTTGCCTGTGAAAGGACACTCCTC -3'
(R):5'- TGCACAAAGTTCTCTCCAGTGCC -3'

Sequencing Primer
(F):5'- TGTGAAAGGACACTCCTCAAAAG -3'
(R):5'- CGTCACAGATAAGGATGTTTCCTG -3'
Posted On 2013-11-08