Incidental Mutation 'R0879:Selenbp2'
ID 81913
Institutional Source Beutler Lab
Gene Symbol Selenbp2
Ensembl Gene ENSMUSG00000068877
Gene Name selenium binding protein 2
Synonyms acetaminophen-binding protein, Lpsb2, AP56
MMRRC Submission 039046-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.346) question?
Stock # R0879 (G1)
Quality Score 225
Status Validated
Chromosome 3
Chromosomal Location 94600880-94611713 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 94606863 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 108 (T108A)
Ref Sequence ENSEMBL: ENSMUSP00000134270 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000090848] [ENSMUST00000131650] [ENSMUST00000173849] [ENSMUST00000173981] [ENSMUST00000174223]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000090848
AA Change: T170A

PolyPhen 2 Score 0.525 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000088358
Gene: ENSMUSG00000068877
AA Change: T170A

DomainStartEndE-ValueType
Pfam:SBP56 6 472 7.8e-227 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000131650
Predicted Effect noncoding transcript
Transcript: ENSMUST00000132162
Predicted Effect possibly damaging
Transcript: ENSMUST00000173849
AA Change: T108A

PolyPhen 2 Score 0.759 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000134270
Gene: ENSMUSG00000068877
AA Change: T108A

DomainStartEndE-ValueType
Pfam:SBP56 6 62 4.4e-22 PFAM
Pfam:SBP56 57 410 4.1e-165 PFAM
Pfam:Lactonase 163 296 4.6e-8 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000173981
SMART Domains Protein: ENSMUSP00000133320
Gene: ENSMUSG00000068877

DomainStartEndE-ValueType
Pfam:SBP56 1 128 3.9e-61 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000174223
SMART Domains Protein: ENSMUSP00000134623
Gene: ENSMUSG00000068877

DomainStartEndE-ValueType
Pfam:SBP56 6 134 3.1e-56 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000174377
Meta Mutation Damage Score 0.6768 question?
Coding Region Coverage
  • 1x: 99.5%
  • 3x: 99.0%
  • 10x: 97.9%
  • 20x: 96.3%
Validation Efficiency 100% (41/41)
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aagab T A 9: 63,524,892 (GRCm39) probably benign Het
Adm A G 7: 110,227,559 (GRCm39) D25G possibly damaging Het
Adprs C T 4: 126,210,410 (GRCm39) V357I probably benign Het
Akap6 G T 12: 52,927,582 (GRCm39) R164L probably damaging Het
Baz2a A G 10: 127,957,173 (GRCm39) N972S probably damaging Het
Brd2 A T 17: 34,332,420 (GRCm39) V232D probably benign Het
C6 A G 15: 4,792,818 (GRCm39) probably benign Het
Ceacam5 A C 7: 17,491,627 (GRCm39) I666L probably benign Het
Col7a1 T C 9: 108,805,159 (GRCm39) probably benign Het
Dnah17 C T 11: 117,947,661 (GRCm39) probably benign Het
Dnah7a A T 1: 53,467,019 (GRCm39) V3615E possibly damaging Het
Eml6 A G 11: 29,800,816 (GRCm39) probably null Het
Enpp2 T C 15: 54,741,326 (GRCm39) E324G probably damaging Het
Fgd4 A G 16: 16,295,313 (GRCm39) V222A probably damaging Het
Gm4076 A G 13: 85,275,326 (GRCm39) noncoding transcript Het
Gm4775 T C 14: 106,338,227 (GRCm39) noncoding transcript Het
Igsf9b T C 9: 27,245,038 (GRCm39) S1002P probably damaging Het
Jag1 A G 2: 136,942,001 (GRCm39) S244P possibly damaging Het
Klhl41 A T 2: 69,513,827 (GRCm39) probably benign Het
Ltbr A G 6: 125,290,338 (GRCm39) probably benign Het
Megf8 A G 7: 25,037,896 (GRCm39) E804G possibly damaging Het
Mybpc1 G A 10: 88,407,378 (GRCm39) probably benign Het
Npas4 T C 19: 5,036,944 (GRCm39) R407G probably benign Het
Oxnad1 T A 14: 31,821,553 (GRCm39) Y213N probably damaging Het
Pde6d A G 1: 86,473,523 (GRCm39) F91S probably benign Het
Pelp1 A G 11: 70,286,123 (GRCm39) probably benign Het
Plscr2 T C 9: 92,169,846 (GRCm39) Y99H probably damaging Het
Rft1 T C 14: 30,404,705 (GRCm39) probably benign Het
Ryr3 T C 2: 112,860,588 (GRCm39) Y30C probably benign Het
Stk32b A G 5: 37,616,940 (GRCm39) probably benign Het
Stra6 T C 9: 58,042,487 (GRCm39) probably null Het
Usp17le A T 7: 104,418,854 (GRCm39) L96Q probably damaging Het
Usp17le G T 7: 104,418,855 (GRCm39) L96M possibly damaging Het
Vmn1r76 A T 7: 11,664,662 (GRCm39) I184N probably benign Het
Vmn2r102 T C 17: 19,914,454 (GRCm39) V673A probably damaging Het
Wdr17 T G 8: 55,114,516 (GRCm39) I667L probably benign Het
Zfp292 T C 4: 34,811,218 (GRCm39) T609A probably benign Het
Zfp821 T C 8: 110,448,474 (GRCm39) I135T possibly damaging Het
Zfp865 A G 7: 5,034,342 (GRCm39) T776A probably benign Het
Zp2 G T 7: 119,734,757 (GRCm39) P477Q probably damaging Het
Other mutations in Selenbp2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01875:Selenbp2 APN 3 94,605,451 (GRCm39) missense possibly damaging 0.76
IGL02007:Selenbp2 APN 3 94,605,461 (GRCm39) missense possibly damaging 0.67
IGL02103:Selenbp2 APN 3 94,605,438 (GRCm39) missense probably null
IGL02222:Selenbp2 APN 3 94,607,269 (GRCm39) missense probably damaging 1.00
IGL02441:Selenbp2 APN 3 94,611,371 (GRCm39) missense probably benign 0.02
IGL03086:Selenbp2 APN 3 94,606,945 (GRCm39) missense probably damaging 1.00
R0068:Selenbp2 UTSW 3 94,610,816 (GRCm39) missense probably benign 0.00
R0256:Selenbp2 UTSW 3 94,607,008 (GRCm39) missense probably benign 0.35
R0725:Selenbp2 UTSW 3 94,604,809 (GRCm39) splice site probably benign
R1636:Selenbp2 UTSW 3 94,604,122 (GRCm39) missense probably damaging 1.00
R3719:Selenbp2 UTSW 3 94,606,924 (GRCm39) missense probably damaging 1.00
R4828:Selenbp2 UTSW 3 94,611,426 (GRCm39) missense probably benign 0.27
R4962:Selenbp2 UTSW 3 94,610,856 (GRCm39) missense probably damaging 0.99
R6661:Selenbp2 UTSW 3 94,609,821 (GRCm39) missense probably damaging 1.00
R7201:Selenbp2 UTSW 3 94,609,664 (GRCm39) missense probably benign 0.03
R7221:Selenbp2 UTSW 3 94,611,133 (GRCm39) nonsense probably null
R7413:Selenbp2 UTSW 3 94,607,404 (GRCm39) missense probably benign 0.03
R8932:Selenbp2 UTSW 3 94,609,793 (GRCm39) missense probably damaging 0.98
R8968:Selenbp2 UTSW 3 94,607,337 (GRCm39) missense probably benign 0.43
R9015:Selenbp2 UTSW 3 94,607,332 (GRCm39) missense probably damaging 1.00
R9380:Selenbp2 UTSW 3 94,609,654 (GRCm39) missense probably benign 0.01
R9516:Selenbp2 UTSW 3 94,607,352 (GRCm39) missense probably benign
R9544:Selenbp2 UTSW 3 94,605,368 (GRCm39) missense possibly damaging 0.78
R9588:Selenbp2 UTSW 3 94,605,368 (GRCm39) missense possibly damaging 0.78
X0050:Selenbp2 UTSW 3 94,611,435 (GRCm39) missense probably damaging 0.99
Z1176:Selenbp2 UTSW 3 94,605,407 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGGTTGGGCAGGTGATACTTACAGG -3'
(R):5'- AGCATCCTAAGCAAGACAAGTGCAG -3'

Sequencing Primer
(F):5'- GATACTTACAGGGTTCAGTCCCAG -3'
(R):5'- TGTGGACTAAGGCCCCTG -3'
Posted On 2013-11-08