Incidental Mutation 'R0944:Spred2'
ID 82016
Institutional Source Beutler Lab
Gene Symbol Spred2
Ensembl Gene ENSMUSG00000045671
Gene Name sprouty-related EVH1 domain containing 2
Synonyms Spred-2
MMRRC Submission 039083-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.442) question?
Stock # R0944 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 19874442-19974026 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to G at 19951104 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000115103 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000093298] [ENSMUST00000093299] [ENSMUST00000123036]
AlphaFold Q924S7
Predicted Effect probably benign
Transcript: ENSMUST00000093298
SMART Domains Protein: ENSMUSP00000090987
Gene: ENSMUSG00000045671

DomainStartEndE-ValueType
Pfam:WH1 6 119 4.7e-13 PFAM
Pfam:Sprouty 298 403 3.8e-44 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000093299
SMART Domains Protein: ENSMUSP00000090988
Gene: ENSMUSG00000045671

DomainStartEndE-ValueType
Pfam:WH1 91 146 4.1e-10 PFAM
Pfam:Sprouty 325 430 8.6e-29 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000123036
SMART Domains Protein: ENSMUSP00000115103
Gene: ENSMUSG00000045671

DomainStartEndE-ValueType
Pfam:WH1 120 175 1.5e-10 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.7%
  • 3x: 99.1%
  • 10x: 97.3%
  • 20x: 94.3%
Validation Efficiency 100% (51/51)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] SPRED2 is a member of the Sprouty (see SPRY1; MIM 602465)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see MAPK1; MIM 176948) (Nonami et al., 2004 [PubMed 15465815]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Homozygous null mice are fertile and display increased hematopoietic cell formation in culture. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3110018I06Rik G A 12: 107,455,268 (GRCm39) R118K unknown Het
Abcc6 T A 7: 45,664,929 (GRCm39) I301F possibly damaging Het
Akap9 C A 5: 4,114,742 (GRCm39) probably null Het
Alg6 A G 4: 99,650,297 (GRCm39) I506V probably benign Het
B3gat1 C T 9: 26,668,237 (GRCm39) R276C probably damaging Het
Camk1 A G 6: 113,315,352 (GRCm39) Y105H probably damaging Het
Ccdc81 T C 7: 89,515,777 (GRCm39) N634S probably damaging Het
Clcn1 C A 6: 42,290,075 (GRCm39) Q837K probably benign Het
Clec16a A G 16: 10,506,510 (GRCm39) probably benign Het
Col22a1 T C 15: 71,753,511 (GRCm39) I130V probably benign Het
Coro2b T C 9: 62,335,263 (GRCm39) S308G probably benign Het
Cpxm1 A G 2: 130,239,423 (GRCm39) W2R probably damaging Het
Csmd3 T C 15: 47,475,227 (GRCm39) N3364S probably damaging Het
Dgkq A G 5: 108,804,331 (GRCm39) V131A probably damaging Het
Dnai1 A G 4: 41,629,997 (GRCm39) S469G probably benign Het
Efcab3 T G 11: 104,601,556 (GRCm39) probably null Het
Eml4 G A 17: 83,785,489 (GRCm39) E885K probably benign Het
Etfa A T 9: 55,396,122 (GRCm39) I148N probably damaging Het
Gpbar1 A G 1: 74,318,681 (GRCm39) D308G probably benign Het
Gprin3 T C 6: 59,330,900 (GRCm39) E469G possibly damaging Het
Igkv1-115 T C 6: 68,138,667 (GRCm39) V90A probably damaging Het
Ints2 A G 11: 86,135,289 (GRCm39) V375A possibly damaging Het
Mindy3 T C 2: 12,400,993 (GRCm39) M242V possibly damaging Het
Or11m3 A G 15: 98,395,565 (GRCm39) I71V probably benign Het
Or1n1b T C 2: 36,780,698 (GRCm39) H54R probably damaging Het
Or5t9 A C 2: 86,659,281 (GRCm39) I62L probably benign Het
P3h1 G A 4: 119,095,956 (GRCm39) E355K probably benign Het
Paxbp1 T C 16: 90,820,315 (GRCm39) T703A probably benign Het
Pcdh15 A T 10: 74,046,302 (GRCm39) Y193F probably damaging Het
Pdxdc1 A G 16: 13,656,233 (GRCm39) V613A probably damaging Het
Plekha5 T C 6: 140,515,922 (GRCm39) probably benign Het
Pmel A T 10: 128,551,126 (GRCm39) Q123L possibly damaging Het
Prl6a1 T C 13: 27,502,149 (GRCm39) probably benign Het
Rcan1 T C 16: 92,190,379 (GRCm39) T187A probably damaging Het
Rp1l1 A G 14: 64,269,681 (GRCm39) S1756G probably benign Het
Runx2 A T 17: 44,919,123 (GRCm39) M405K probably damaging Het
Serinc5 T C 13: 92,797,613 (GRCm39) Y39H probably damaging Het
Sgsm1 G A 5: 113,413,740 (GRCm39) T676I probably benign Het
Slc6a15 G C 10: 103,245,657 (GRCm39) V547L probably benign Het
Slk T C 19: 47,597,432 (GRCm39) I80T probably damaging Het
Spice1 A G 16: 44,205,124 (GRCm39) N810S probably benign Het
Tbc1d4 C G 14: 101,716,656 (GRCm39) probably benign Het
Tdrd7 G A 4: 46,029,762 (GRCm39) V1032M probably benign Het
Tlr11 A G 14: 50,599,793 (GRCm39) N593S probably benign Het
Trpa1 T C 1: 14,982,585 (GRCm39) probably null Het
Ugcg C T 4: 59,207,798 (GRCm39) P46S probably benign Het
Usp25 T C 16: 76,878,335 (GRCm39) probably benign Het
Vmn2r97 T A 17: 19,167,665 (GRCm39) S640T probably benign Het
Zc3h6 A G 2: 128,848,736 (GRCm39) Y321C probably damaging Het
Zfp329 T A 7: 12,545,395 (GRCm39) N43I probably benign Het
Other mutations in Spred2
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0512:Spred2 UTSW 11 19,958,485 (GRCm39) splice site probably benign
R1467:Spred2 UTSW 11 19,968,109 (GRCm39) missense probably benign 0.00
R1467:Spred2 UTSW 11 19,968,109 (GRCm39) missense probably benign 0.00
R2156:Spred2 UTSW 11 19,971,241 (GRCm39) missense probably damaging 1.00
R2915:Spred2 UTSW 11 19,948,215 (GRCm39) missense probably damaging 1.00
R3433:Spred2 UTSW 11 19,948,277 (GRCm39) nonsense probably null
R4839:Spred2 UTSW 11 19,948,233 (GRCm39) missense possibly damaging 0.53
R5100:Spred2 UTSW 11 19,971,291 (GRCm39) nonsense probably null
R5353:Spred2 UTSW 11 19,968,155 (GRCm39) missense possibly damaging 0.82
R5529:Spred2 UTSW 11 19,971,301 (GRCm39) missense probably damaging 1.00
R5709:Spred2 UTSW 11 19,971,415 (GRCm39) missense probably damaging 1.00
R6978:Spred2 UTSW 11 19,948,254 (GRCm39) missense possibly damaging 0.73
R7345:Spred2 UTSW 11 19,874,958 (GRCm39) critical splice donor site probably null
R8073:Spred2 UTSW 11 19,958,422 (GRCm39) missense probably benign 0.45
R8847:Spred2 UTSW 11 19,951,064 (GRCm39) missense probably benign 0.03
R8888:Spred2 UTSW 11 19,951,019 (GRCm39) missense probably benign 0.11
R8895:Spred2 UTSW 11 19,951,019 (GRCm39) missense probably benign 0.11
X0025:Spred2 UTSW 11 19,948,234 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- GAGGGACATCTTCTCCCACCTTTTG -3'
(R):5'- GTAGTAGCTCACAGGCTCCAACAC -3'

Sequencing Primer
(F):5'- TGTAAGTATGTGACTCTGCTTCC -3'
(R):5'- TACACAGTACCTTGGATCACCTC -3'
Posted On 2013-11-08