Mutagenetix > Incidental Mutation

Incidental Mutation 'R0946:Or11g7'

82126

Institutional Source

Beutler Lab

Gene Symbol

Or11g7

Ensembl Gene

ENSMUSG00000095917

Gene Name

olfactory receptor family 11 subfamily G member 7

Synonyms

MOR106-4, Olfr740, GA_x6K02T2PMLR-6167145-6168080

MMRRC Submission

039085-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.080) question?

Stock #

R0946 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

50690511-50693135 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 50691130 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Lysine at position 207 (T207K)

Ref Sequence

ENSEMBL: ENSMUSP00000148916 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000089838] [ENSMUST00000214792]

AlphaFold

E9PV79

Predicted Effect

probably benign
Transcript: ENSMUST00000089838
AA Change: T207K

PolyPhen 2 Score 0.129 (Sensitivity: 0.93; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000087276
Gene: ENSMUSG00000095917
AA Change: T207K

Domain	Start	End	E-Value	Type
Pfam:7tm_4	35	311	2.3e-56	PFAM
Pfam:7tm_1	45	294	1.6e-21	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000214792
AA Change: T207K

PolyPhen 2 Score 0.129 (Sensitivity: 0.93; Specificity: 0.86)

Coding Region Coverage

1x: 99.4%
3x: 98.9%
10x: 97.5%
20x: 95.2%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9230112D13Rik	A	G	14: 34,234,099 (GRCm39)	M64T	unknown	Het
Adamts15	C	T	9: 30,813,493 (GRCm39)	G891R	probably damaging	Het
Adck5	G	A	15: 76,477,486 (GRCm39)	V107I	possibly damaging	Het
Aoc3	G	A	11: 101,223,131 (GRCm39)	V456M	possibly damaging	Het
Apbb1	A	T	7: 105,223,062 (GRCm39)	L183Q	probably benign	Het
Camsap3	A	G	8: 3,654,442 (GRCm39)	H693R	probably benign	Het
Ccdc88a	A	G	11: 29,406,509 (GRCm39)	T414A	probably benign	Het
Cdh17	T	C	4: 11,795,581 (GRCm39)	V387A	probably benign	Het
Coasy	G	T	11: 100,976,696 (GRCm39)	V489F	probably damaging	Het
Ercc6	A	T	14: 32,274,578 (GRCm39)	M574L	probably benign	Het
Esrrb	T	C	12: 86,552,598 (GRCm39)	L180P	probably damaging	Het
Fam83b	A	T	9: 76,398,679 (GRCm39)	V808D	probably damaging	Het
Fat3	C	T	9: 15,909,100 (GRCm39)	V2301I	possibly damaging	Het
Ftdc1	C	A	16: 58,435,075 (GRCm39)	R83S	probably damaging	Het
Hyal4	T	A	6: 24,755,912 (GRCm39)	Y43*	probably null	Het
Hydin	C	A	8: 111,257,685 (GRCm39)	L2372M	probably benign	Het
Lrrc4c	T	C	2: 97,459,809 (GRCm39)	V145A	probably benign	Het
Lypd10	A	G	7: 24,413,167 (GRCm39)	K162R	probably benign	Het
Muc21	A	C	17: 35,929,105 (GRCm39)	S1581A	probably benign	Het
Myh4	A	G	11: 67,142,577 (GRCm39)	I913V	possibly damaging	Het
Nat10	C	T	2: 103,561,719 (GRCm39)	G654D	probably damaging	Het
Nbn	A	T	4: 15,970,719 (GRCm39)		probably null	Het
Nup50l	A	T	6: 96,142,677 (GRCm39)	N122K	possibly damaging	Het
Oas3	T	C	5: 120,907,128 (GRCm39)	Y503C	unknown	Het
Pappa	G	T	4: 65,233,029 (GRCm39)		probably null	Het
Pfas	A	G	11: 68,884,121 (GRCm39)		probably null	Het
Pfas	G	T	11: 68,881,573 (GRCm39)		probably null	Het
Pign	A	T	1: 105,519,422 (GRCm39)	M500K	probably benign	Het
Pkhd1	T	C	1: 20,269,605 (GRCm39)	K3313R	probably benign	Het
Ptk2b	A	G	14: 66,396,047 (GRCm39)	V807A	probably benign	Het
Ptpdc1	C	T	13: 48,740,286 (GRCm39)	E382K	probably damaging	Het
Rfpl4b	A	T	10: 38,696,833 (GRCm39)	I256N	probably benign	Het
Skap1	C	G	11: 96,432,295 (GRCm39)	S88*	probably null	Het
Slc4a2	T	C	5: 24,640,884 (GRCm39)	S742P	probably damaging	Het
Supv3l1	T	C	10: 62,265,599 (GRCm39)	D647G	probably damaging	Het
Tmem184c	A	C	8: 78,331,386 (GRCm39)	V121G	probably damaging	Het
Tonsl	T	C	15: 76,507,421 (GRCm39)	I118V	probably benign	Het
Top1	T	A	2: 160,554,588 (GRCm39)	Y446*	probably null	Het
Trim37	A	G	11: 87,037,781 (GRCm39)	R172G	probably damaging	Het
Vgll4	C	A	6: 114,867,768 (GRCm39)		probably null	Het
Vgll4	T	A	6: 114,867,769 (GRCm39)		probably null	Het
Vmn1r5	T	G	6: 56,963,150 (GRCm39)	I275S	possibly damaging	Het
Vwde	A	T	6: 13,187,874 (GRCm39)	H584Q	probably damaging	Het
Zbtb14	C	A	17: 69,695,497 (GRCm39)	F398L	probably damaging	Het
Zfp282	T	A	6: 47,856,943 (GRCm39)	W59R	probably damaging	Het
Zfp329	T	A	7: 12,545,395 (GRCm39)	N43I	probably benign	Het
Zswim2	T	A	2: 83,754,103 (GRCm39)	T186S	probably benign	Het

Other mutations in Or11g7

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01663:Or11g7	APN	14	50,690,607 (GRCm39)	missense	probably benign	0.04
IGL02117:Or11g7	APN	14	50,691,399 (GRCm39)	missense	possibly damaging	0.91
IGL02663:Or11g7	APN	14	50,691,309 (GRCm39)	missense	probably benign	0.02
IGL02858:Or11g7	APN	14	50,690,507 (GRCm39)	utr 5 prime	probably benign
IGL02955:Or11g7	APN	14	50,691,442 (GRCm39)	missense	probably damaging	0.99
IGL03210:Or11g7	APN	14	50,691,440 (GRCm39)	missense	probably benign	0.10
IGL03249:Or11g7	APN	14	50,690,668 (GRCm39)	missense	probably damaging	0.98
G1Funyon:Or11g7	UTSW	14	50,691,021 (GRCm39)	missense	probably benign	0.08
R1449:Or11g7	UTSW	14	50,691,378 (GRCm39)	missense	probably damaging	1.00
R1465:Or11g7	UTSW	14	50,690,634 (GRCm39)	missense	possibly damaging	0.91
R1465:Or11g7	UTSW	14	50,690,634 (GRCm39)	missense	possibly damaging	0.91
R1513:Or11g7	UTSW	14	50,691,138 (GRCm39)	missense	probably benign	0.00
R1908:Or11g7	UTSW	14	50,691,295 (GRCm39)	missense	probably damaging	0.99
R2422:Or11g7	UTSW	14	50,690,893 (GRCm39)	missense	probably damaging	1.00
R3406:Or11g7	UTSW	14	50,690,653 (GRCm39)	missense	probably benign	0.14
R4184:Or11g7	UTSW	14	50,690,827 (GRCm39)	missense	probably damaging	1.00
R4795:Or11g7	UTSW	14	50,690,874 (GRCm39)	missense	probably damaging	0.96
R5028:Or11g7	UTSW	14	50,691,196 (GRCm39)	missense	probably damaging	1.00
R5436:Or11g7	UTSW	14	50,691,184 (GRCm39)	missense	probably damaging	1.00
R6057:Or11g7	UTSW	14	50,691,201 (GRCm39)	nonsense	probably null
R6455:Or11g7	UTSW	14	50,691,042 (GRCm39)	missense	possibly damaging	0.92
R6903:Or11g7	UTSW	14	50,691,412 (GRCm39)	missense	possibly damaging	0.93
R6998:Or11g7	UTSW	14	50,690,890 (GRCm39)	missense	probably benign	0.29
R7671:Or11g7	UTSW	14	50,691,342 (GRCm39)	missense	probably benign	0.04
R8048:Or11g7	UTSW	14	50,691,373 (GRCm39)	missense	possibly damaging	0.52
R8301:Or11g7	UTSW	14	50,691,021 (GRCm39)	missense	probably benign	0.08
X0066:Or11g7	UTSW	14	50,691,115 (GRCm39)	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- GATACCTTGCCATCTGTAGGCCAC -3'
(R):5'- TGCTCAGAGGTCGGGCTTAGATAC -3'

Sequencing Primer
(F):5'- CTGCAACATCCTTGTGATCAG -3'
(R):5'- GGTCGGGCTTAGATACATTATCATC -3'

Posted On

2013-11-08