Incidental Mutation 'R0791:Ces1f'
ID 82399
Institutional Source Beutler Lab
Gene Symbol Ces1f
Ensembl Gene ENSMUSG00000031725
Gene Name carboxylesterase 1F
Synonyms CesML1, TGH-2
MMRRC Submission 038971-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.059) question?
Stock # R0791 (G1)
Quality Score 225
Status Validated
Chromosome 8
Chromosomal Location 93982864-94006375 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 93998517 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Asparagine at position 160 (Y160N)
Ref Sequence ENSEMBL: ENSMUSP00000034178 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034178] [ENSMUST00000140026]
AlphaFold Q91WU0
Predicted Effect possibly damaging
Transcript: ENSMUST00000034178
AA Change: Y160N

PolyPhen 2 Score 0.516 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000034178
Gene: ENSMUSG00000031725
AA Change: Y160N

DomainStartEndE-ValueType
Pfam:COesterase 1 545 2.5e-166 PFAM
Pfam:Abhydrolase_3 136 244 4e-8 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000124066
Predicted Effect noncoding transcript
Transcript: ENSMUST00000133879
Predicted Effect probably benign
Transcript: ENSMUST00000140026
SMART Domains Protein: ENSMUSP00000116525
Gene: ENSMUSG00000031725

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000151261
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.3%
  • 20x: 94.8%
Validation Efficiency 98% (59/60)
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahnak G A 19: 8,994,098 (GRCm39) M5127I probably benign Het
Akr1c13 T C 13: 4,244,111 (GRCm39) Y55H probably damaging Het
Armh3 A T 19: 45,922,307 (GRCm39) probably null Het
Atp2b2 C T 6: 113,750,349 (GRCm39) R625H probably damaging Het
Bpifb2 T C 2: 153,720,439 (GRCm39) V66A probably benign Het
Ccdc33 T C 9: 57,936,046 (GRCm39) T950A possibly damaging Het
Ceacam19 A T 7: 19,616,557 (GRCm39) probably null Het
Cenpn T A 8: 117,667,559 (GRCm39) probably benign Het
Clca3a1 A C 3: 144,710,615 (GRCm39) S863A probably benign Het
Cntrl T A 2: 35,045,291 (GRCm39) I781K possibly damaging Het
Dock4 C T 12: 40,754,480 (GRCm39) R490W probably damaging Het
Evpl T A 11: 116,118,549 (GRCm39) Q686L probably damaging Het
Fbxw10 A G 11: 62,738,282 (GRCm39) S59G probably benign Het
Glb1l2 A G 9: 26,681,047 (GRCm39) V218A possibly damaging Het
Gpatch1 A T 7: 34,980,801 (GRCm39) probably benign Het
Grin2c G A 11: 115,141,472 (GRCm39) P882L probably damaging Het
H2-Ob C A 17: 34,461,588 (GRCm39) T109N probably damaging Het
Ipo8 A G 6: 148,723,225 (GRCm39) V64A possibly damaging Het
Jpt2 C A 17: 25,167,647 (GRCm39) A101S probably benign Het
Lamc1 C A 1: 153,110,326 (GRCm39) Q1116H possibly damaging Het
Lamc1 T C 1: 153,110,358 (GRCm39) S1106G probably benign Het
Lamc1 T G 1: 153,110,341 (GRCm39) Q1111H probably damaging Het
Large1 A G 8: 73,775,107 (GRCm39) probably benign Het
Lig4 A T 8: 10,023,012 (GRCm39) V256E possibly damaging Het
Mpz C A 1: 170,986,343 (GRCm39) Q86K possibly damaging Het
Mrps24 A G 11: 5,654,684 (GRCm39) V90A possibly damaging Het
Mtdh A G 15: 34,116,528 (GRCm39) probably benign Het
Mtor T C 4: 148,547,367 (GRCm39) V450A probably benign Het
Mycbpap A G 11: 94,402,449 (GRCm39) probably null Het
Myo6 T A 9: 80,169,656 (GRCm39) probably benign Het
Myom1 A T 17: 71,428,131 (GRCm39) I1450F probably damaging Het
Nbas T A 12: 13,532,634 (GRCm39) S1781T probably benign Het
Nedd1 T C 10: 92,555,476 (GRCm39) E3G probably damaging Het
Nt5c3 T C 6: 56,863,734 (GRCm39) T149A probably benign Het
Or5p56 A G 7: 107,589,740 (GRCm39) H56R probably benign Het
Osbp2 G A 11: 3,661,882 (GRCm39) probably benign Het
Paip1 T C 13: 119,566,854 (GRCm39) S54P possibly damaging Het
Pole2 G A 12: 69,254,703 (GRCm39) L381F probably benign Het
Prdm14 G T 1: 13,195,968 (GRCm39) A31E probably benign Het
Ptpn14 C T 1: 189,568,637 (GRCm39) probably benign Het
Rims2 A G 15: 39,543,021 (GRCm39) probably benign Het
Rnf20 A G 4: 49,638,197 (GRCm39) N103S possibly damaging Het
Sema3g T A 14: 30,942,861 (GRCm39) probably benign Het
Slc30a6 T C 17: 74,722,640 (GRCm39) S236P possibly damaging Het
Slc5a1 T C 5: 33,315,421 (GRCm39) probably benign Het
Snx25 A T 8: 46,577,119 (GRCm39) M1K probably null Het
Synpo2 A G 3: 122,906,835 (GRCm39) V827A probably benign Het
Tns2 C T 15: 102,017,369 (GRCm39) R281C probably damaging Het
Trak2 A T 1: 58,942,820 (GRCm39) M862K probably benign Het
Trim42 A T 9: 97,247,732 (GRCm39) H321Q probably damaging Het
Twnk T C 19: 44,998,693 (GRCm39) probably benign Het
Tymp T C 15: 89,259,021 (GRCm39) K221R probably damaging Het
Uaca C A 9: 60,779,341 (GRCm39) Q1243K possibly damaging Het
Vwa8 T C 14: 79,232,016 (GRCm39) probably benign Het
Wnt4 C T 4: 137,016,594 (GRCm39) R83W probably damaging Het
Zfp820 T C 17: 22,038,509 (GRCm39) D273G probably benign Het
Zfp974 A T 7: 27,609,510 (GRCm39) Y738* probably null Het
Zkscan4 A C 13: 21,668,081 (GRCm39) E177D probably benign Het
Other mutations in Ces1f
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00334:Ces1f APN 8 93,994,620 (GRCm39) missense probably benign
IGL01143:Ces1f APN 8 93,998,458 (GRCm39) critical splice donor site probably null
IGL01571:Ces1f APN 8 93,984,996 (GRCm39) missense probably benign 0.00
IGL01731:Ces1f APN 8 93,993,948 (GRCm39) missense possibly damaging 0.73
IGL01733:Ces1f APN 8 93,996,642 (GRCm39) missense probably damaging 1.00
IGL02124:Ces1f APN 8 93,992,488 (GRCm39) missense possibly damaging 0.54
IGL03058:Ces1f APN 8 93,996,600 (GRCm39) critical splice donor site probably null
IGL03124:Ces1f APN 8 94,002,012 (GRCm39) missense probably benign
3-1:Ces1f UTSW 8 94,002,059 (GRCm39) missense probably benign 0.29
G5030:Ces1f UTSW 8 94,000,847 (GRCm39) missense probably benign 0.03
R0025:Ces1f UTSW 8 93,998,513 (GRCm39) missense probably benign 0.27
R0025:Ces1f UTSW 8 93,998,513 (GRCm39) missense probably benign 0.27
R0113:Ces1f UTSW 8 94,006,327 (GRCm39) start codon destroyed probably null 0.93
R0201:Ces1f UTSW 8 93,993,957 (GRCm39) missense probably null 0.01
R0306:Ces1f UTSW 8 94,003,172 (GRCm39) splice site probably benign
R0317:Ces1f UTSW 8 93,990,019 (GRCm39) missense probably benign 0.05
R0558:Ces1f UTSW 8 94,002,017 (GRCm39) missense probably benign
R0833:Ces1f UTSW 8 93,996,652 (GRCm39) missense probably damaging 0.98
R0836:Ces1f UTSW 8 93,996,652 (GRCm39) missense probably damaging 0.98
R1087:Ces1f UTSW 8 93,984,923 (GRCm39) missense probably damaging 1.00
R1118:Ces1f UTSW 8 93,993,870 (GRCm39) splice site probably benign
R1147:Ces1f UTSW 8 93,984,909 (GRCm39) missense possibly damaging 0.89
R1147:Ces1f UTSW 8 93,984,909 (GRCm39) missense possibly damaging 0.89
R1183:Ces1f UTSW 8 93,994,633 (GRCm39) missense probably benign 0.01
R1371:Ces1f UTSW 8 94,006,277 (GRCm39) missense probably damaging 0.98
R1480:Ces1f UTSW 8 94,000,782 (GRCm39) missense probably benign 0.07
R1522:Ces1f UTSW 8 93,998,517 (GRCm39) missense possibly damaging 0.52
R1681:Ces1f UTSW 8 94,002,042 (GRCm39) missense probably benign 0.00
R1865:Ces1f UTSW 8 94,000,893 (GRCm39) splice site probably benign
R2437:Ces1f UTSW 8 93,996,767 (GRCm39) splice site probably null
R3038:Ces1f UTSW 8 93,983,226 (GRCm39) missense probably damaging 1.00
R4199:Ces1f UTSW 8 93,983,517 (GRCm39) missense probably benign 0.00
R4406:Ces1f UTSW 8 93,989,950 (GRCm39) missense probably benign
R5385:Ces1f UTSW 8 93,992,388 (GRCm39) nonsense probably null
R5450:Ces1f UTSW 8 93,992,423 (GRCm39) missense probably benign 0.04
R5627:Ces1f UTSW 8 94,006,327 (GRCm39) start codon destroyed probably null 0.93
R6182:Ces1f UTSW 8 93,983,124 (GRCm39) missense probably benign 0.43
R6256:Ces1f UTSW 8 93,992,422 (GRCm39) missense probably damaging 1.00
R6379:Ces1f UTSW 8 94,006,279 (GRCm39) missense probably benign
R6443:Ces1f UTSW 8 94,001,993 (GRCm39) missense probably benign 0.00
R6967:Ces1f UTSW 8 93,994,625 (GRCm39) missense probably benign 0.00
R7158:Ces1f UTSW 8 93,994,644 (GRCm39) missense probably benign 0.00
R7323:Ces1f UTSW 8 93,998,472 (GRCm39) missense probably damaging 1.00
R7654:Ces1f UTSW 8 93,998,562 (GRCm39) missense probably benign 0.00
R7810:Ces1f UTSW 8 93,983,546 (GRCm39) missense probably damaging 1.00
R7812:Ces1f UTSW 8 93,984,938 (GRCm39) missense probably benign 0.00
R7864:Ces1f UTSW 8 94,000,769 (GRCm39) missense possibly damaging 0.65
R7999:Ces1f UTSW 8 93,989,623 (GRCm39) missense possibly damaging 0.77
R9048:Ces1f UTSW 8 93,989,695 (GRCm39) missense probably benign 0.32
R9289:Ces1f UTSW 8 93,992,491 (GRCm39) missense probably benign 0.06
R9389:Ces1f UTSW 8 93,996,600 (GRCm39) critical splice donor site probably null
R9598:Ces1f UTSW 8 93,983,494 (GRCm39) missense probably benign 0.27
R9745:Ces1f UTSW 8 93,989,740 (GRCm39) missense probably benign 0.18
X0026:Ces1f UTSW 8 93,996,684 (GRCm39) missense probably benign 0.12
Predicted Primers PCR Primer
(F):5'- ATGCAGTCCTTGGTATCCCACCAC -3'
(R):5'- GGTGAACTTTGAGCATCATGCCCTG -3'

Sequencing Primer
(F):5'- TTGGTATCCCACCACTCCAAAC -3'
(R):5'- ATCAGGGCCAGGCCAAG -3'
Posted On 2013-11-08