Incidental Mutation 'R0791:Zfp820'
ID 82426
Institutional Source Beutler Lab
Gene Symbol Zfp820
Ensembl Gene ENSMUSG00000069743
Gene Name zinc finger protein 820
Synonyms 2610036F08Rik
MMRRC Submission 038971-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.130) question?
Stock # R0791 (G1)
Quality Score 191
Status Validated
Chromosome 17
Chromosomal Location 22035857-22064740 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 22038509 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 273 (D273G)
Ref Sequence ENSEMBL: ENSMUSP00000081158 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084141]
AlphaFold A0A3B2W7H5
Predicted Effect probably benign
Transcript: ENSMUST00000084141
AA Change: D273G

PolyPhen 2 Score 0.046 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000081158
Gene: ENSMUSG00000069743
AA Change: D273G

DomainStartEndE-ValueType
KRAB 13 73 8.77e-20 SMART
ZnF_C2H2 183 205 6.32e-3 SMART
ZnF_C2H2 211 233 2.79e-4 SMART
ZnF_C2H2 239 261 4.3e-5 SMART
ZnF_C2H2 267 289 4.61e-5 SMART
ZnF_C2H2 295 317 1.2e-3 SMART
ZnF_C2H2 323 345 1.22e-4 SMART
ZnF_C2H2 351 373 2.75e-3 SMART
ZnF_C2H2 379 401 2.95e-3 SMART
ZnF_C2H2 407 429 5.29e-5 SMART
ZnF_C2H2 435 457 1.42e-5 SMART
ZnF_C2H2 463 485 1.2e-3 SMART
ZnF_C2H2 491 513 1.13e-4 SMART
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.3%
  • 20x: 94.8%
Validation Efficiency 98% (59/60)
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahnak G A 19: 8,994,098 (GRCm39) M5127I probably benign Het
Akr1c13 T C 13: 4,244,111 (GRCm39) Y55H probably damaging Het
Armh3 A T 19: 45,922,307 (GRCm39) probably null Het
Atp2b2 C T 6: 113,750,349 (GRCm39) R625H probably damaging Het
Bpifb2 T C 2: 153,720,439 (GRCm39) V66A probably benign Het
Ccdc33 T C 9: 57,936,046 (GRCm39) T950A possibly damaging Het
Ceacam19 A T 7: 19,616,557 (GRCm39) probably null Het
Cenpn T A 8: 117,667,559 (GRCm39) probably benign Het
Ces1f A T 8: 93,998,517 (GRCm39) Y160N possibly damaging Het
Clca3a1 A C 3: 144,710,615 (GRCm39) S863A probably benign Het
Cntrl T A 2: 35,045,291 (GRCm39) I781K possibly damaging Het
Dock4 C T 12: 40,754,480 (GRCm39) R490W probably damaging Het
Evpl T A 11: 116,118,549 (GRCm39) Q686L probably damaging Het
Fbxw10 A G 11: 62,738,282 (GRCm39) S59G probably benign Het
Glb1l2 A G 9: 26,681,047 (GRCm39) V218A possibly damaging Het
Gpatch1 A T 7: 34,980,801 (GRCm39) probably benign Het
Grin2c G A 11: 115,141,472 (GRCm39) P882L probably damaging Het
H2-Ob C A 17: 34,461,588 (GRCm39) T109N probably damaging Het
Ipo8 A G 6: 148,723,225 (GRCm39) V64A possibly damaging Het
Jpt2 C A 17: 25,167,647 (GRCm39) A101S probably benign Het
Lamc1 C A 1: 153,110,326 (GRCm39) Q1116H possibly damaging Het
Lamc1 T C 1: 153,110,358 (GRCm39) S1106G probably benign Het
Lamc1 T G 1: 153,110,341 (GRCm39) Q1111H probably damaging Het
Large1 A G 8: 73,775,107 (GRCm39) probably benign Het
Lig4 A T 8: 10,023,012 (GRCm39) V256E possibly damaging Het
Mpz C A 1: 170,986,343 (GRCm39) Q86K possibly damaging Het
Mrps24 A G 11: 5,654,684 (GRCm39) V90A possibly damaging Het
Mtdh A G 15: 34,116,528 (GRCm39) probably benign Het
Mtor T C 4: 148,547,367 (GRCm39) V450A probably benign Het
Mycbpap A G 11: 94,402,449 (GRCm39) probably null Het
Myo6 T A 9: 80,169,656 (GRCm39) probably benign Het
Myom1 A T 17: 71,428,131 (GRCm39) I1450F probably damaging Het
Nbas T A 12: 13,532,634 (GRCm39) S1781T probably benign Het
Nedd1 T C 10: 92,555,476 (GRCm39) E3G probably damaging Het
Nt5c3 T C 6: 56,863,734 (GRCm39) T149A probably benign Het
Or5p56 A G 7: 107,589,740 (GRCm39) H56R probably benign Het
Osbp2 G A 11: 3,661,882 (GRCm39) probably benign Het
Paip1 T C 13: 119,566,854 (GRCm39) S54P possibly damaging Het
Pole2 G A 12: 69,254,703 (GRCm39) L381F probably benign Het
Prdm14 G T 1: 13,195,968 (GRCm39) A31E probably benign Het
Ptpn14 C T 1: 189,568,637 (GRCm39) probably benign Het
Rims2 A G 15: 39,543,021 (GRCm39) probably benign Het
Rnf20 A G 4: 49,638,197 (GRCm39) N103S possibly damaging Het
Sema3g T A 14: 30,942,861 (GRCm39) probably benign Het
Slc30a6 T C 17: 74,722,640 (GRCm39) S236P possibly damaging Het
Slc5a1 T C 5: 33,315,421 (GRCm39) probably benign Het
Snx25 A T 8: 46,577,119 (GRCm39) M1K probably null Het
Synpo2 A G 3: 122,906,835 (GRCm39) V827A probably benign Het
Tns2 C T 15: 102,017,369 (GRCm39) R281C probably damaging Het
Trak2 A T 1: 58,942,820 (GRCm39) M862K probably benign Het
Trim42 A T 9: 97,247,732 (GRCm39) H321Q probably damaging Het
Twnk T C 19: 44,998,693 (GRCm39) probably benign Het
Tymp T C 15: 89,259,021 (GRCm39) K221R probably damaging Het
Uaca C A 9: 60,779,341 (GRCm39) Q1243K possibly damaging Het
Vwa8 T C 14: 79,232,016 (GRCm39) probably benign Het
Wnt4 C T 4: 137,016,594 (GRCm39) R83W probably damaging Het
Zfp974 A T 7: 27,609,510 (GRCm39) Y738* probably null Het
Zkscan4 A C 13: 21,668,081 (GRCm39) E177D probably benign Het
Other mutations in Zfp820
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00424:Zfp820 APN 17 22,038,292 (GRCm39) missense probably damaging 1.00
IGL00954:Zfp820 APN 17 22,038,860 (GRCm39) missense probably damaging 1.00
IGL01088:Zfp820 APN 17 22,040,162 (GRCm39) nonsense probably null
IGL03067:Zfp820 APN 17 22,038,801 (GRCm39) missense possibly damaging 0.68
R0158:Zfp820 UTSW 17 22,038,800 (GRCm39) missense probably benign 0.06
R0617:Zfp820 UTSW 17 22,038,685 (GRCm39) missense probably damaging 0.99
R0658:Zfp820 UTSW 17 22,037,901 (GRCm39) missense probably benign 0.00
R0696:Zfp820 UTSW 17 22,039,041 (GRCm39) missense possibly damaging 0.94
R0792:Zfp820 UTSW 17 22,038,509 (GRCm39) missense probably benign 0.05
R0882:Zfp820 UTSW 17 22,042,817 (GRCm39) splice site probably benign
R1421:Zfp820 UTSW 17 22,038,861 (GRCm39) missense possibly damaging 0.85
R1573:Zfp820 UTSW 17 22,037,737 (GRCm39) missense probably benign 0.00
R1928:Zfp820 UTSW 17 22,038,316 (GRCm39) missense probably benign 0.00
R3889:Zfp820 UTSW 17 22,037,877 (GRCm39) missense probably benign 0.25
R4782:Zfp820 UTSW 17 22,037,966 (GRCm39) missense probably benign 0.00
R4799:Zfp820 UTSW 17 22,037,966 (GRCm39) missense probably benign 0.00
R4807:Zfp820 UTSW 17 22,042,853 (GRCm39) start codon destroyed probably null 1.00
R4913:Zfp820 UTSW 17 22,038,200 (GRCm39) missense probably benign 0.42
R5100:Zfp820 UTSW 17 22,040,054 (GRCm39) missense possibly damaging 0.64
R5766:Zfp820 UTSW 17 22,038,983 (GRCm39) missense probably damaging 0.96
R5772:Zfp820 UTSW 17 22,037,702 (GRCm39) missense probably damaging 1.00
R6516:Zfp820 UTSW 17 22,038,354 (GRCm39) missense probably damaging 1.00
R6577:Zfp820 UTSW 17 22,038,384 (GRCm39) missense probably benign 0.00
R7094:Zfp820 UTSW 17 22,038,246 (GRCm39) missense probably benign 0.41
R7570:Zfp820 UTSW 17 22,037,994 (GRCm39) missense probably benign 0.14
R7794:Zfp820 UTSW 17 22,039,109 (GRCm39) missense probably damaging 0.98
R8545:Zfp820 UTSW 17 22,038,438 (GRCm39) missense probably damaging 1.00
R8692:Zfp820 UTSW 17 22,037,876 (GRCm39) missense probably benign 0.43
R9072:Zfp820 UTSW 17 22,039,031 (GRCm39) missense possibly damaging 0.91
R9073:Zfp820 UTSW 17 22,039,031 (GRCm39) missense possibly damaging 0.91
R9325:Zfp820 UTSW 17 22,038,380 (GRCm39) missense probably damaging 1.00
R9421:Zfp820 UTSW 17 22,038,336 (GRCm39) missense probably benign 0.20
R9480:Zfp820 UTSW 17 22,037,994 (GRCm39) missense possibly damaging 0.85
R9592:Zfp820 UTSW 17 22,038,577 (GRCm39) missense probably benign 0.01
R9600:Zfp820 UTSW 17 22,038,861 (GRCm39) missense probably benign 0.00
R9632:Zfp820 UTSW 17 22,038,107 (GRCm39) missense probably damaging 1.00
Predicted Primers
Posted On 2013-11-08