Mutagenetix > Incidental Mutation

Incidental Mutation 'R0791:Armh3'

82433

Institutional Source

Beutler Lab

Gene Symbol

Armh3

Ensembl Gene

ENSMUSG00000039901

Gene Name

armadillo-like helical domain containing 3

Synonyms

9130011E15Rik

MMRRC Submission

038971-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R0791 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

45805803-45986927 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

A to T at 45922307 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000048454 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000045396]

AlphaFold

Q6PD19

Predicted Effect

probably null
Transcript: ENSMUST00000045396

SMART Domains

Protein: ENSMUSP00000048454
Gene: ENSMUSG00000039901

Domain	Start	End	E-Value	Type
low complexity region	155	167	N/A	INTRINSIC
low complexity region	327	348	N/A	INTRINSIC
DUF1741	435	671	5.65e-139	SMART

Meta Mutation Damage Score

0.9755

Coding Region Coverage

1x: 99.4%
3x: 98.8%
10x: 97.3%
20x: 94.8%

Validation Efficiency

98% (59/60)

Allele List at MGI

Other mutations in this stock

Total: 58 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ahnak	G	A	19: 8,994,098 (GRCm39)	M5127I	probably benign	Het
Akr1c13	T	C	13: 4,244,111 (GRCm39)	Y55H	probably damaging	Het
Atp2b2	C	T	6: 113,750,349 (GRCm39)	R625H	probably damaging	Het
Bpifb2	T	C	2: 153,720,439 (GRCm39)	V66A	probably benign	Het
Ccdc33	T	C	9: 57,936,046 (GRCm39)	T950A	possibly damaging	Het
Ceacam19	A	T	7: 19,616,557 (GRCm39)		probably null	Het
Cenpn	T	A	8: 117,667,559 (GRCm39)		probably benign	Het
Ces1f	A	T	8: 93,998,517 (GRCm39)	Y160N	possibly damaging	Het
Clca3a1	A	C	3: 144,710,615 (GRCm39)	S863A	probably benign	Het
Cntrl	T	A	2: 35,045,291 (GRCm39)	I781K	possibly damaging	Het
Dock4	C	T	12: 40,754,480 (GRCm39)	R490W	probably damaging	Het
Evpl	T	A	11: 116,118,549 (GRCm39)	Q686L	probably damaging	Het
Fbxw10	A	G	11: 62,738,282 (GRCm39)	S59G	probably benign	Het
Glb1l2	A	G	9: 26,681,047 (GRCm39)	V218A	possibly damaging	Het
Gpatch1	A	T	7: 34,980,801 (GRCm39)		probably benign	Het
Grin2c	G	A	11: 115,141,472 (GRCm39)	P882L	probably damaging	Het
H2-Ob	C	A	17: 34,461,588 (GRCm39)	T109N	probably damaging	Het
Ipo8	A	G	6: 148,723,225 (GRCm39)	V64A	possibly damaging	Het
Jpt2	C	A	17: 25,167,647 (GRCm39)	A101S	probably benign	Het
Lamc1	C	A	1: 153,110,326 (GRCm39)	Q1116H	possibly damaging	Het
Lamc1	T	C	1: 153,110,358 (GRCm39)	S1106G	probably benign	Het
Lamc1	T	G	1: 153,110,341 (GRCm39)	Q1111H	probably damaging	Het
Large1	A	G	8: 73,775,107 (GRCm39)		probably benign	Het
Lig4	A	T	8: 10,023,012 (GRCm39)	V256E	possibly damaging	Het
Mpz	C	A	1: 170,986,343 (GRCm39)	Q86K	possibly damaging	Het
Mrps24	A	G	11: 5,654,684 (GRCm39)	V90A	possibly damaging	Het
Mtdh	A	G	15: 34,116,528 (GRCm39)		probably benign	Het
Mtor	T	C	4: 148,547,367 (GRCm39)	V450A	probably benign	Het
Mycbpap	A	G	11: 94,402,449 (GRCm39)		probably null	Het
Myo6	T	A	9: 80,169,656 (GRCm39)		probably benign	Het
Myom1	A	T	17: 71,428,131 (GRCm39)	I1450F	probably damaging	Het
Nbas	T	A	12: 13,532,634 (GRCm39)	S1781T	probably benign	Het
Nedd1	T	C	10: 92,555,476 (GRCm39)	E3G	probably damaging	Het
Nt5c3	T	C	6: 56,863,734 (GRCm39)	T149A	probably benign	Het
Or5p56	A	G	7: 107,589,740 (GRCm39)	H56R	probably benign	Het
Osbp2	G	A	11: 3,661,882 (GRCm39)		probably benign	Het
Paip1	T	C	13: 119,566,854 (GRCm39)	S54P	possibly damaging	Het
Pole2	G	A	12: 69,254,703 (GRCm39)	L381F	probably benign	Het
Prdm14	G	T	1: 13,195,968 (GRCm39)	A31E	probably benign	Het
Ptpn14	C	T	1: 189,568,637 (GRCm39)		probably benign	Het
Rims2	A	G	15: 39,543,021 (GRCm39)		probably benign	Het
Rnf20	A	G	4: 49,638,197 (GRCm39)	N103S	possibly damaging	Het
Sema3g	T	A	14: 30,942,861 (GRCm39)		probably benign	Het
Slc30a6	T	C	17: 74,722,640 (GRCm39)	S236P	possibly damaging	Het
Slc5a1	T	C	5: 33,315,421 (GRCm39)		probably benign	Het
Snx25	A	T	8: 46,577,119 (GRCm39)	M1K	probably null	Het
Synpo2	A	G	3: 122,906,835 (GRCm39)	V827A	probably benign	Het
Tns2	C	T	15: 102,017,369 (GRCm39)	R281C	probably damaging	Het
Trak2	A	T	1: 58,942,820 (GRCm39)	M862K	probably benign	Het
Trim42	A	T	9: 97,247,732 (GRCm39)	H321Q	probably damaging	Het
Twnk	T	C	19: 44,998,693 (GRCm39)		probably benign	Het
Tymp	T	C	15: 89,259,021 (GRCm39)	K221R	probably damaging	Het
Uaca	C	A	9: 60,779,341 (GRCm39)	Q1243K	possibly damaging	Het
Vwa8	T	C	14: 79,232,016 (GRCm39)		probably benign	Het
Wnt4	C	T	4: 137,016,594 (GRCm39)	R83W	probably damaging	Het
Zfp820	T	C	17: 22,038,509 (GRCm39)	D273G	probably benign	Het
Zfp974	A	T	7: 27,609,510 (GRCm39)	Y738*	probably null	Het
Zkscan4	A	C	13: 21,668,081 (GRCm39)	E177D	probably benign	Het

Other mutations in Armh3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00392:Armh3	APN	19	45,928,927 (GRCm39)	missense	probably benign	0.19
IGL00788:Armh3	APN	19	45,920,789 (GRCm39)	critical splice donor site	probably null
IGL01356:Armh3	APN	19	45,954,742 (GRCm39)	missense	possibly damaging	0.94
IGL01477:Armh3	APN	19	45,967,043 (GRCm39)	missense	probably damaging	0.99
IGL01660:Armh3	APN	19	45,928,915 (GRCm39)	missense	probably damaging	1.00
IGL02193:Armh3	APN	19	45,961,323 (GRCm39)	missense	probably benign	0.02
IGL02863:Armh3	APN	19	45,946,850 (GRCm39)	missense	probably damaging	1.00
IGL03108:Armh3	APN	19	45,808,792 (GRCm39)	missense	probably damaging	0.99
R0035:Armh3	UTSW	19	45,879,679 (GRCm39)	missense	probably damaging	1.00
R0792:Armh3	UTSW	19	45,922,307 (GRCm39)	splice site	probably null
R1487:Armh3	UTSW	19	45,928,882 (GRCm39)	critical splice donor site	probably null
R1843:Armh3	UTSW	19	45,963,691 (GRCm39)	missense	probably benign	0.17
R2061:Armh3	UTSW	19	45,967,106 (GRCm39)	missense	probably damaging	1.00
R2070:Armh3	UTSW	19	45,879,724 (GRCm39)	missense	probably damaging	1.00
R2072:Armh3	UTSW	19	45,953,820 (GRCm39)	missense	probably damaging	0.99
R2073:Armh3	UTSW	19	45,953,820 (GRCm39)	missense	probably damaging	0.99
R2074:Armh3	UTSW	19	45,953,820 (GRCm39)	missense	probably damaging	0.99
R2091:Armh3	UTSW	19	45,941,119 (GRCm39)	missense	probably damaging	1.00
R2263:Armh3	UTSW	19	45,920,788 (GRCm39)	critical splice donor site	probably null
R2863:Armh3	UTSW	19	45,874,396 (GRCm39)	missense	probably damaging	1.00
R3236:Armh3	UTSW	19	45,963,722 (GRCm39)	splice site	probably benign
R3796:Armh3	UTSW	19	45,910,049 (GRCm39)	splice site	probably benign
R4044:Armh3	UTSW	19	45,808,763 (GRCm39)	missense	probably damaging	1.00
R4716:Armh3	UTSW	19	45,948,781 (GRCm39)	missense	probably damaging	1.00
R4974:Armh3	UTSW	19	45,808,726 (GRCm39)	missense	probably damaging	1.00
R4983:Armh3	UTSW	19	45,939,146 (GRCm39)	missense	probably benign
R5063:Armh3	UTSW	19	45,874,394 (GRCm39)	missense	possibly damaging	0.95
R5313:Armh3	UTSW	19	45,807,414 (GRCm39)	missense	probably damaging	1.00
R5782:Armh3	UTSW	19	45,874,466 (GRCm39)	missense	probably benign	0.08
R5985:Armh3	UTSW	19	45,808,763 (GRCm39)	missense	probably damaging	1.00
R6220:Armh3	UTSW	19	45,834,554 (GRCm39)	missense	possibly damaging	0.79
R6379:Armh3	UTSW	19	45,910,136 (GRCm39)	missense	possibly damaging	0.46
R6674:Armh3	UTSW	19	45,963,437 (GRCm39)	missense	probably benign	0.06
R6842:Armh3	UTSW	19	45,807,416 (GRCm39)	missense	probably benign	0.05
R6890:Armh3	UTSW	19	45,948,796 (GRCm39)	missense	probably damaging	1.00
R7034:Armh3	UTSW	19	45,953,688 (GRCm39)	missense	probably damaging	0.98
R7036:Armh3	UTSW	19	45,953,688 (GRCm39)	missense	probably damaging	0.98
R7305:Armh3	UTSW	19	45,880,560 (GRCm39)	missense	probably benign	0.35
R7411:Armh3	UTSW	19	45,953,874 (GRCm39)	missense	probably benign	0.00
R7762:Armh3	UTSW	19	45,928,882 (GRCm39)	critical splice donor site	probably null
R8021:Armh3	UTSW	19	45,945,180 (GRCm39)	critical splice acceptor site	probably null
R8366:Armh3	UTSW	19	45,920,793 (GRCm39)	missense	probably damaging	1.00
R9336:Armh3	UTSW	19	45,945,120 (GRCm39)	missense	probably damaging	1.00
X0060:Armh3	UTSW	19	45,920,832 (GRCm39)	missense	possibly damaging	0.95
Z1088:Armh3	UTSW	19	45,807,344 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- AAGTCTCCGTCCTGAAAGTCACCG -3'
(R):5'- GCTTGCCTTTACCAACTGAAGCATC -3'

Sequencing Primer
(F):5'- GTTCTTGTCAGCAGCCTTCT -3'
(R):5'- AATGACAGTAGCAACATTCGTC -3'

Posted On

2013-11-08