Incidental Mutation 'R0792:Raver2'
ID 82449
Institutional Source Beutler Lab
Gene Symbol Raver2
Ensembl Gene ENSMUSG00000035275
Gene Name ribonucleoprotein, PTB-binding 2
Synonyms A430091O22Rik
MMRRC Submission 038972-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.082) question?
Stock # R0792 (G1)
Quality Score 225
Status Not validated
Chromosome 4
Chromosomal Location 100926235-101009567 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 100960147 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Aspartic acid at position 209 (V209D)
Ref Sequence ENSEMBL: ENSMUSP00000102568 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000038463] [ENSMUST00000106955]
AlphaFold Q7TPD6
Predicted Effect possibly damaging
Transcript: ENSMUST00000038463
AA Change: V209D

PolyPhen 2 Score 0.908 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000043142
Gene: ENSMUSG00000035275
AA Change: V209D

DomainStartEndE-ValueType
low complexity region 2 29 N/A INTRINSIC
RRM 59 125 8.2e-11 SMART
RRM 132 205 1.67e-11 SMART
RRM 221 294 2.12e-4 SMART
low complexity region 362 379 N/A INTRINSIC
low complexity region 499 512 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000106955
AA Change: V209D

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000102568
Gene: ENSMUSG00000035275
AA Change: V209D

DomainStartEndE-ValueType
low complexity region 2 29 N/A INTRINSIC
RRM 59 125 8.2e-11 SMART
RRM 132 205 1.67e-11 SMART
RRM 221 294 2.12e-4 SMART
low complexity region 362 379 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000148148
Predicted Effect noncoding transcript
Transcript: ENSMUST00000157926
Coding Region Coverage
  • 1x: 99.7%
  • 3x: 99.1%
  • 10x: 97.6%
  • 20x: 95.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsl5 T C 19: 55,268,924 (GRCm39) V195A probably benign Het
Adgrb1 A G 15: 74,452,466 (GRCm39) M211V probably damaging Het
Ahnak G T 19: 8,994,098 (GRCm39) M5127I probably benign Het
Akr1c13 T C 13: 4,244,111 (GRCm39) Y55H probably damaging Het
Ap3d1 A T 10: 80,544,313 (GRCm39) H1161Q probably benign Het
Armh3 A T 19: 45,922,307 (GRCm39) probably null Het
Atp2b2 C T 6: 113,750,349 (GRCm39) R625H probably damaging Het
Bdnf G A 2: 109,554,463 (GRCm39) C239Y probably damaging Het
Bpifa5 G T 2: 154,007,539 (GRCm39) probably null Het
C9 T A 15: 6,516,243 (GRCm39) F349I probably damaging Het
Ccdc180 T C 4: 45,927,975 (GRCm39) V1170A possibly damaging Het
Celsr1 A G 15: 85,815,477 (GRCm39) V1846A probably benign Het
Cep68 A T 11: 20,190,652 (GRCm39) L120H possibly damaging Het
Cntrl T A 2: 35,045,291 (GRCm39) I781K possibly damaging Het
Cpne1 G T 2: 155,919,339 (GRCm39) Q343K probably benign Het
Dlc1 A T 8: 37,405,702 (GRCm39) I29K probably benign Het
Dnah9 T C 11: 65,786,827 (GRCm39) D3602G possibly damaging Het
Dock1 A G 7: 134,475,879 (GRCm39) S885G probably benign Het
Evpl T A 11: 116,118,549 (GRCm39) Q686L probably damaging Het
Fmo6 C T 1: 162,748,132 (GRCm39) A311T probably damaging Het
Gli1 A T 10: 127,168,446 (GRCm39) M469K probably damaging Het
Grin2c G A 11: 115,141,472 (GRCm39) P882L probably damaging Het
H2-Ob C T 17: 34,461,588 (GRCm39) T109I probably damaging Het
Jpt2 C A 17: 25,167,647 (GRCm39) A101S probably benign Het
Krt1c A G 15: 101,724,932 (GRCm39) V226A probably damaging Het
Lamc1 T C 1: 153,110,358 (GRCm39) S1106G probably benign Het
Lamc1 C A 1: 153,110,326 (GRCm39) Q1116H possibly damaging Het
Lamc1 T G 1: 153,110,341 (GRCm39) Q1111H probably damaging Het
Lrp1 G T 10: 127,403,233 (GRCm39) D2113E probably damaging Het
Lrp1 A T 10: 127,411,155 (GRCm39) D1399E probably benign Het
Ltbp4 G T 7: 27,024,485 (GRCm39) P715Q probably damaging Het
Mtor T C 4: 148,547,367 (GRCm39) V450A probably benign Het
Muc6 G A 7: 141,223,981 (GRCm39) probably benign Het
Myom1 A T 17: 71,428,131 (GRCm39) I1450F probably damaging Het
Naip6 A G 13: 100,420,274 (GRCm39) I1332T possibly damaging Het
Ncstn A G 1: 171,899,072 (GRCm39) V353A possibly damaging Het
Nt5c3 T C 6: 56,863,734 (GRCm39) T149A probably benign Het
Or5ac21 A T 16: 59,124,352 (GRCm39) I280F probably damaging Het
Or5p81 A G 7: 108,267,364 (GRCm39) H247R probably damaging Het
Paip1 T C 13: 119,566,854 (GRCm39) S54P possibly damaging Het
Prdm14 G T 1: 13,195,968 (GRCm39) A31E probably benign Het
Prr14l A G 5: 32,985,767 (GRCm39) S1243P probably damaging Het
Prss1 T C 6: 41,435,878 (GRCm39) M1T probably null Het
Scube1 T A 15: 83,512,277 (GRCm39) probably null Het
Serpina3c T A 12: 104,117,805 (GRCm39) I178F probably damaging Het
Slc16a13 A T 11: 70,111,457 (GRCm39) V16E probably damaging Het
Slc30a6 T C 17: 74,722,640 (GRCm39) S236P possibly damaging Het
Sobp A C 10: 42,898,689 (GRCm39) S299A probably damaging Het
Sorcs3 C A 19: 48,694,448 (GRCm39) T574K possibly damaging Het
Trak2 A T 1: 58,942,820 (GRCm39) M862K probably benign Het
Ubox5 A T 2: 130,442,630 (GRCm39) V19E probably damaging Het
Vmn1r173 A G 7: 23,402,160 (GRCm39) T132A probably benign Het
Zfp267 A G 3: 36,218,711 (GRCm39) M244V probably benign Het
Zfp820 T C 17: 22,038,509 (GRCm39) D273G probably benign Het
Other mutations in Raver2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00325:Raver2 APN 4 100,960,065 (GRCm39) missense probably damaging 1.00
IGL00778:Raver2 APN 4 100,953,468 (GRCm39) missense probably benign 0.00
IGL01363:Raver2 APN 4 100,977,780 (GRCm39) splice site probably benign
IGL02631:Raver2 APN 4 100,953,499 (GRCm39) missense probably damaging 0.96
R0071:Raver2 UTSW 4 100,977,642 (GRCm39) splice site probably benign
R0071:Raver2 UTSW 4 100,977,642 (GRCm39) splice site probably benign
R1450:Raver2 UTSW 4 100,993,349 (GRCm39) missense possibly damaging 0.58
R2044:Raver2 UTSW 4 100,960,009 (GRCm39) missense probably damaging 1.00
R5127:Raver2 UTSW 4 100,960,182 (GRCm39) missense probably damaging 1.00
R5162:Raver2 UTSW 4 100,959,921 (GRCm39) missense probably damaging 1.00
R5342:Raver2 UTSW 4 100,959,889 (GRCm39) missense possibly damaging 0.47
R5557:Raver2 UTSW 4 100,993,336 (GRCm39) missense probably benign 0.04
R6190:Raver2 UTSW 4 100,990,814 (GRCm39) missense probably benign 0.00
R6248:Raver2 UTSW 4 100,991,320 (GRCm39) splice site probably null
R6449:Raver2 UTSW 4 100,990,869 (GRCm39) missense probably benign 0.41
R6640:Raver2 UTSW 4 100,988,500 (GRCm39) missense probably damaging 0.98
R6852:Raver2 UTSW 4 100,990,787 (GRCm39) missense probably benign 0.00
R7196:Raver2 UTSW 4 100,960,056 (GRCm39) missense probably damaging 1.00
R7449:Raver2 UTSW 4 100,959,860 (GRCm39) missense probably damaging 1.00
R7459:Raver2 UTSW 4 100,964,410 (GRCm39) missense possibly damaging 0.83
R8025:Raver2 UTSW 4 100,960,162 (GRCm39) nonsense probably null
R8843:Raver2 UTSW 4 100,994,942 (GRCm39) missense probably damaging 0.96
R8898:Raver2 UTSW 4 100,964,399 (GRCm39) critical splice acceptor site probably null
R9290:Raver2 UTSW 4 100,977,387 (GRCm39) intron probably benign
RF017:Raver2 UTSW 4 100,960,195 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- AGTTTGAAGAACTCGTCCGTGCC -3'
(R):5'- CTGCCACTGTGACCTGGATAAGAC -3'

Sequencing Primer
(F):5'- TGCCTATGGCAACATCGAG -3'
(R):5'- CTGTGACCTGGATAAGACACATTAAC -3'
Posted On 2013-11-08