Mutagenetix > Incidental Mutation

Incidental Mutation 'R0792:Vmn1r173'

82455

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r173

Ensembl Gene

ENSMUSG00000115021

Gene Name

vomeronasal 1 receptor 173

Synonyms

Gm5892

MMRRC Submission

038972-MU

Accession Numbers

Essential gene?

Possibly essential (E-score: 0.621) question?

Stock #

R0792 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

23401767-23402708 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 23402160 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 132 (T132A)

Ref Sequence

ENSEMBL: ENSMUSP00000153884 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000174055] [ENSMUST00000226233] [ENSMUST00000227987]

AlphaFold

E9Q8V7

Predicted Effect

probably benign
Transcript: ENSMUST00000174055
AA Change: T132A

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)

SMART Domains

Protein: ENSMUSP00000134645
Gene: ENSMUSG00000115021
AA Change: T132A

Domain	Start	End	E-Value	Type
transmembrane domain	13	35	N/A	INTRINSIC
Pfam:V1R	43	301	5.3e-20	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000226233
AA Change: T132A

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)

Predicted Effect

probably benign
Transcript: ENSMUST00000227987
AA Change: T132A

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)

Coding Region Coverage

1x: 99.7%
3x: 99.1%
10x: 97.6%
20x: 95.1%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 54 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acsl5	T	C	19: 55,268,924 (GRCm39)	V195A	probably benign	Het
Adgrb1	A	G	15: 74,452,466 (GRCm39)	M211V	probably damaging	Het
Ahnak	G	T	19: 8,994,098 (GRCm39)	M5127I	probably benign	Het
Akr1c13	T	C	13: 4,244,111 (GRCm39)	Y55H	probably damaging	Het
Ap3d1	A	T	10: 80,544,313 (GRCm39)	H1161Q	probably benign	Het
Armh3	A	T	19: 45,922,307 (GRCm39)		probably null	Het
Atp2b2	C	T	6: 113,750,349 (GRCm39)	R625H	probably damaging	Het
Bdnf	G	A	2: 109,554,463 (GRCm39)	C239Y	probably damaging	Het
Bpifa5	G	T	2: 154,007,539 (GRCm39)		probably null	Het
C9	T	A	15: 6,516,243 (GRCm39)	F349I	probably damaging	Het
Ccdc180	T	C	4: 45,927,975 (GRCm39)	V1170A	possibly damaging	Het
Celsr1	A	G	15: 85,815,477 (GRCm39)	V1846A	probably benign	Het
Cep68	A	T	11: 20,190,652 (GRCm39)	L120H	possibly damaging	Het
Cntrl	T	A	2: 35,045,291 (GRCm39)	I781K	possibly damaging	Het
Cpne1	G	T	2: 155,919,339 (GRCm39)	Q343K	probably benign	Het
Dlc1	A	T	8: 37,405,702 (GRCm39)	I29K	probably benign	Het
Dnah9	T	C	11: 65,786,827 (GRCm39)	D3602G	possibly damaging	Het
Dock1	A	G	7: 134,475,879 (GRCm39)	S885G	probably benign	Het
Evpl	T	A	11: 116,118,549 (GRCm39)	Q686L	probably damaging	Het
Fmo6	C	T	1: 162,748,132 (GRCm39)	A311T	probably damaging	Het
Gli1	A	T	10: 127,168,446 (GRCm39)	M469K	probably damaging	Het
Grin2c	G	A	11: 115,141,472 (GRCm39)	P882L	probably damaging	Het
H2-Ob	C	T	17: 34,461,588 (GRCm39)	T109I	probably damaging	Het
Jpt2	C	A	17: 25,167,647 (GRCm39)	A101S	probably benign	Het
Krt1c	A	G	15: 101,724,932 (GRCm39)	V226A	probably damaging	Het
Lamc1	T	C	1: 153,110,358 (GRCm39)	S1106G	probably benign	Het
Lamc1	C	A	1: 153,110,326 (GRCm39)	Q1116H	possibly damaging	Het
Lamc1	T	G	1: 153,110,341 (GRCm39)	Q1111H	probably damaging	Het
Lrp1	G	T	10: 127,403,233 (GRCm39)	D2113E	probably damaging	Het
Lrp1	A	T	10: 127,411,155 (GRCm39)	D1399E	probably benign	Het
Ltbp4	G	T	7: 27,024,485 (GRCm39)	P715Q	probably damaging	Het
Mtor	T	C	4: 148,547,367 (GRCm39)	V450A	probably benign	Het
Muc6	G	A	7: 141,223,981 (GRCm39)		probably benign	Het
Myom1	A	T	17: 71,428,131 (GRCm39)	I1450F	probably damaging	Het
Naip6	A	G	13: 100,420,274 (GRCm39)	I1332T	possibly damaging	Het
Ncstn	A	G	1: 171,899,072 (GRCm39)	V353A	possibly damaging	Het
Nt5c3	T	C	6: 56,863,734 (GRCm39)	T149A	probably benign	Het
Or5ac21	A	T	16: 59,124,352 (GRCm39)	I280F	probably damaging	Het
Or5p81	A	G	7: 108,267,364 (GRCm39)	H247R	probably damaging	Het
Paip1	T	C	13: 119,566,854 (GRCm39)	S54P	possibly damaging	Het
Prdm14	G	T	1: 13,195,968 (GRCm39)	A31E	probably benign	Het
Prr14l	A	G	5: 32,985,767 (GRCm39)	S1243P	probably damaging	Het
Prss1	T	C	6: 41,435,878 (GRCm39)	M1T	probably null	Het
Raver2	T	A	4: 100,960,147 (GRCm39)	V209D	probably damaging	Het
Scube1	T	A	15: 83,512,277 (GRCm39)		probably null	Het
Serpina3c	T	A	12: 104,117,805 (GRCm39)	I178F	probably damaging	Het
Slc16a13	A	T	11: 70,111,457 (GRCm39)	V16E	probably damaging	Het
Slc30a6	T	C	17: 74,722,640 (GRCm39)	S236P	possibly damaging	Het
Sobp	A	C	10: 42,898,689 (GRCm39)	S299A	probably damaging	Het
Sorcs3	C	A	19: 48,694,448 (GRCm39)	T574K	possibly damaging	Het
Trak2	A	T	1: 58,942,820 (GRCm39)	M862K	probably benign	Het
Ubox5	A	T	2: 130,442,630 (GRCm39)	V19E	probably damaging	Het
Zfp267	A	G	3: 36,218,711 (GRCm39)	M244V	probably benign	Het
Zfp820	T	C	17: 22,038,509 (GRCm39)	D273G	probably benign	Het

Other mutations in Vmn1r173

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01490:Vmn1r173	APN	7	23,402,132 (GRCm39)	missense	probably benign	0.01
IGL01637:Vmn1r173	APN	7	23,402,373 (GRCm39)	missense	probably damaging	0.96
IGL01878:Vmn1r173	APN	7	23,401,877 (GRCm39)	missense	probably damaging	1.00
IGL02036:Vmn1r173	APN	7	23,402,321 (GRCm39)	missense	probably benign	0.04
IGL02039:Vmn1r173	APN	7	23,402,321 (GRCm39)	missense	probably benign	0.04
IGL02171:Vmn1r173	APN	7	23,402,321 (GRCm39)	missense	probably benign	0.04
IGL02209:Vmn1r173	APN	7	23,402,586 (GRCm39)	missense	probably benign	0.25
PIT4515001:Vmn1r173	UTSW	7	23,401,911 (GRCm39)	nonsense	probably null
R0157:Vmn1r173	UTSW	7	23,401,822 (GRCm39)	missense	probably damaging	0.99
R0226:Vmn1r173	UTSW	7	23,402,508 (GRCm39)	missense	possibly damaging	0.65
R0482:Vmn1r173	UTSW	7	23,402,216 (GRCm39)	missense	probably damaging	0.99
R1242:Vmn1r173	UTSW	7	23,402,650 (GRCm39)	missense	probably damaging	1.00
R1390:Vmn1r173	UTSW	7	23,402,323 (GRCm39)	missense	possibly damaging	0.82
R1641:Vmn1r173	UTSW	7	23,402,533 (GRCm39)	missense	probably benign	0.06
R1867:Vmn1r173	UTSW	7	23,402,660 (GRCm39)	missense	unknown
R2325:Vmn1r173	UTSW	7	23,402,537 (GRCm39)	nonsense	probably null
R3863:Vmn1r173	UTSW	7	23,401,977 (GRCm39)	missense	probably damaging	1.00
R4407:Vmn1r173	UTSW	7	23,402,441 (GRCm39)	missense	probably damaging	1.00
R4717:Vmn1r173	UTSW	7	23,402,637 (GRCm39)	missense	probably damaging	1.00
R4841:Vmn1r173	UTSW	7	23,402,361 (GRCm39)	missense	probably damaging	1.00
R4842:Vmn1r173	UTSW	7	23,402,361 (GRCm39)	missense	probably damaging	1.00
R5966:Vmn1r173	UTSW	7	23,402,112 (GRCm39)	missense	probably benign	0.00
R6022:Vmn1r173	UTSW	7	23,402,260 (GRCm39)	missense	probably benign	0.07
R6114:Vmn1r173	UTSW	7	23,402,254 (GRCm39)	missense	possibly damaging	0.53
R6657:Vmn1r173	UTSW	7	23,402,320 (GRCm39)	missense	probably damaging	0.98
R7165:Vmn1r173	UTSW	7	23,402,076 (GRCm39)	missense	probably benign	0.00
R7195:Vmn1r173	UTSW	7	23,401,884 (GRCm39)	missense	probably damaging	0.99
R7201:Vmn1r173	UTSW	7	23,401,583 (GRCm39)	start gained	probably benign
R7533:Vmn1r173	UTSW	7	23,402,071 (GRCm39)	missense	probably benign	0.05
R7951:Vmn1r173	UTSW	7	23,402,680 (GRCm39)	missense	unknown
R8351:Vmn1r173	UTSW	7	23,401,957 (GRCm39)	nonsense	probably null
R8374:Vmn1r173	UTSW	7	23,401,920 (GRCm39)	missense	probably damaging	0.98
R8427:Vmn1r173	UTSW	7	23,401,959 (GRCm39)	missense	probably damaging	0.99
R8451:Vmn1r173	UTSW	7	23,401,957 (GRCm39)	nonsense	probably null
R8923:Vmn1r173	UTSW	7	23,401,768 (GRCm39)	start codon destroyed	probably null	1.00
R9126:Vmn1r173	UTSW	7	23,402,008 (GRCm39)	missense	probably benign	0.23
R9506:Vmn1r173	UTSW	7	23,401,963 (GRCm39)	missense	probably damaging	0.99
R9557:Vmn1r173	UTSW	7	23,402,209 (GRCm39)	missense	probably damaging	1.00
X0022:Vmn1r173	UTSW	7	23,402,012 (GRCm39)	missense	probably benign	0.06

Predicted Primers

PCR Primer
(F):5'- TTTGCTGGCCCTCAACTGAGAC -3'
(R):5'- GCTCCCATTGGACCTGTGAATGTG -3'

Sequencing Primer
(F):5'- CACTGGGTTTCCAAGCAATATC -3'
(R):5'- GTCCATACCATGATGCTGATGAAC -3'

Posted On

2013-11-08