Incidental Mutation 'R0850:Fbxw25'
| ID |
82523 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Fbxw25
|
| Ensembl Gene |
ENSMUSG00000094992 |
| Gene Name |
F-box and WD-40 domain protein 25 |
| Synonyms |
E330001B16Rik |
| MMRRC Submission |
039029-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.059)
|
| Stock # |
R0850 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
9 |
| Chromosomal Location |
109474190-109493720 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 109478685 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Lysine to Arginine
at position 425
(K425R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000128652
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000163839]
|
| AlphaFold |
F7C9P2 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000163839
AA Change: K425R
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000128652
Gene: ENSMUSG00000094992
AA Change: K425R
| Domain | Start | End | E-Value | Type |
|---|
|
FBOX
|
5 |
45 |
5.44e-6 |
SMART |
|
SCOP:d1gxra_
|
119 |
228 |
1e-6 |
SMART |
|
Blast:WD40
|
137 |
176 |
6e-6 |
BLAST |
|
| Coding Region Coverage |
- 1x: 99.5%
- 3x: 99.0%
- 10x: 97.8%
- 20x: 96.1%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 33 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930433I11Rik |
A |
T |
7: 40,642,480 (GRCm39) |
T141S |
probably benign |
Het |
| Aadacl2fm2 |
T |
G |
3: 59,659,669 (GRCm39) |
I374R |
possibly damaging |
Het |
| Agbl3 |
T |
A |
6: 34,776,139 (GRCm39) |
F210Y |
probably damaging |
Het |
| Dgkq |
A |
G |
5: 108,802,444 (GRCm39) |
V418A |
possibly damaging |
Het |
| Dmp1 |
A |
T |
5: 104,360,653 (GRCm39) |
D443V |
possibly damaging |
Het |
| Elapor2 |
T |
A |
5: 9,467,993 (GRCm39) |
N220K |
probably damaging |
Het |
| Elavl3 |
T |
G |
9: 21,948,059 (GRCm39) |
D35A |
probably damaging |
Het |
| Fbxo44 |
C |
G |
4: 148,240,726 (GRCm39) |
R220S |
probably damaging |
Het |
| Gypa |
A |
G |
8: 81,222,974 (GRCm39) |
H26R |
unknown |
Het |
| H2-DMb1 |
T |
C |
17: 34,374,536 (GRCm39) |
V62A |
probably benign |
Het |
| Helb |
T |
C |
10: 119,941,272 (GRCm39) |
H472R |
probably damaging |
Het |
| Herc1 |
T |
G |
9: 66,373,952 (GRCm39) |
V3197G |
probably damaging |
Het |
| Herc2 |
C |
A |
7: 55,854,231 (GRCm39) |
N3712K |
probably benign |
Het |
| Herc6 |
T |
C |
6: 57,560,227 (GRCm39) |
V89A |
possibly damaging |
Het |
| Hspa1l |
A |
G |
17: 35,196,599 (GRCm39) |
T213A |
probably benign |
Het |
| Kcna7 |
T |
C |
7: 45,058,855 (GRCm39) |
S381P |
probably damaging |
Het |
| Kif19a |
C |
A |
11: 114,671,613 (GRCm39) |
P164Q |
probably damaging |
Het |
| Macf1 |
A |
G |
4: 123,368,195 (GRCm39) |
S2189P |
probably benign |
Het |
| Mpo |
A |
G |
11: 87,688,328 (GRCm39) |
N329S |
probably damaging |
Het |
| Mrps15 |
A |
G |
4: 125,942,479 (GRCm39) |
Y76C |
probably damaging |
Het |
| Or51a42 |
T |
A |
7: 103,708,252 (GRCm39) |
M186L |
probably benign |
Het |
| Or6c75 |
T |
C |
10: 129,337,593 (GRCm39) |
V280A |
probably damaging |
Het |
| Prdm2 |
T |
C |
4: 142,858,773 (GRCm39) |
R1506G |
possibly damaging |
Het |
| Ptprb |
A |
T |
10: 116,138,030 (GRCm39) |
Q311H |
possibly damaging |
Het |
| Ptprb |
T |
C |
10: 116,175,415 (GRCm39) |
Y1137H |
probably damaging |
Het |
| Scaf8 |
A |
G |
17: 3,246,049 (GRCm39) |
|
probably null |
Het |
| Slc25a1 |
A |
T |
16: 17,745,145 (GRCm39) |
F105Y |
probably benign |
Het |
| Slc29a4 |
T |
C |
5: 142,704,327 (GRCm39) |
V327A |
probably benign |
Het |
| Spmip3 |
A |
G |
1: 177,568,571 (GRCm39) |
T23A |
probably benign |
Het |
| Tmed10 |
A |
G |
12: 85,390,279 (GRCm39) |
F195L |
probably benign |
Het |
| Tmem45a2 |
T |
A |
16: 56,865,732 (GRCm39) |
I151F |
probably benign |
Het |
| Vmn2r93 |
C |
A |
17: 18,525,279 (GRCm39) |
F312L |
possibly damaging |
Het |
| Zfp326 |
A |
G |
5: 106,026,663 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Fbxw25 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL03330:Fbxw25
|
APN |
9 |
109,474,307 (GRCm39) |
missense |
probably benign |
0.00 |
|
doughnuts
|
UTSW |
9 |
109,479,132 (GRCm39) |
missense |
|
|
|
goodtimes
|
UTSW |
9 |
109,492,442 (GRCm39) |
critical splice donor site |
probably null |
|
|
shakeys
|
UTSW |
9 |
109,483,651 (GRCm39) |
missense |
|
|
|
R0158:Fbxw25
|
UTSW |
9 |
109,483,720 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R1109:Fbxw25
|
UTSW |
9 |
109,479,128 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1386:Fbxw25
|
UTSW |
9 |
109,483,709 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R1609:Fbxw25
|
UTSW |
9 |
109,492,578 (GRCm39) |
missense |
probably benign |
0.11 |
|
R1750:Fbxw25
|
UTSW |
9 |
109,479,141 (GRCm39) |
missense |
probably benign |
0.23 |
|
R1977:Fbxw25
|
UTSW |
9 |
109,481,924 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R2427:Fbxw25
|
UTSW |
9 |
109,481,928 (GRCm39) |
missense |
probably benign |
0.09 |
|
R3841:Fbxw25
|
UTSW |
9 |
109,491,202 (GRCm39) |
nonsense |
probably null |
|
|
R4356:Fbxw25
|
UTSW |
9 |
109,491,153 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4934:Fbxw25
|
UTSW |
9 |
109,480,705 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R5024:Fbxw25
|
UTSW |
9 |
109,492,442 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5175:Fbxw25
|
UTSW |
9 |
109,493,631 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5323:Fbxw25
|
UTSW |
9 |
109,492,573 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5389:Fbxw25
|
UTSW |
9 |
109,481,954 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5493:Fbxw25
|
UTSW |
9 |
109,481,984 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6268:Fbxw25
|
UTSW |
9 |
109,483,718 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6739:Fbxw25
|
UTSW |
9 |
109,480,699 (GRCm39) |
missense |
probably benign |
0.29 |
|
R7275:Fbxw25
|
UTSW |
9 |
109,483,660 (GRCm39) |
missense |
|
|
|
R7492:Fbxw25
|
UTSW |
9 |
109,493,598 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7623:Fbxw25
|
UTSW |
9 |
109,483,651 (GRCm39) |
missense |
|
|
|
R7784:Fbxw25
|
UTSW |
9 |
109,479,187 (GRCm39) |
missense |
|
|
|
R7861:Fbxw25
|
UTSW |
9 |
109,493,625 (GRCm39) |
nonsense |
probably null |
|
|
R7887:Fbxw25
|
UTSW |
9 |
109,478,662 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8973:Fbxw25
|
UTSW |
9 |
109,479,132 (GRCm39) |
missense |
|
|
|
R9517:Fbxw25
|
UTSW |
9 |
109,480,892 (GRCm39) |
missense |
|
|
|
R9563:Fbxw25
|
UTSW |
9 |
109,483,676 (GRCm39) |
missense |
|
|
|
R9565:Fbxw25
|
UTSW |
9 |
109,483,676 (GRCm39) |
missense |
|
|
|
X0023:Fbxw25
|
UTSW |
9 |
109,480,843 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
Z1176:Fbxw25
|
UTSW |
9 |
109,480,806 (GRCm39) |
missense |
|
|
|
| Predicted Primers |
PCR Primer
(F):5'- TGTGCTGAGATCCCAAGAACTAGCAA -3'
(R):5'- GTCTGACATTGACTCCAGCCTACTAACA -3'
Sequencing Primer
(F):5'- ggagtgggtgggttggg -3'
(R):5'- TCGTCACCTGTAACAATGGC -3'
|
| Posted On |
2013-11-08 |
Incidental Mutation