Incidental Mutation 'R0941:Gpc1'
ID |
82564 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Gpc1
|
Ensembl Gene |
ENSMUSG00000034220 |
Gene Name |
glypican 1 |
Synonyms |
|
MMRRC Submission |
039080-MU
|
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
R0941 (G1)
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
1 |
Chromosomal Location |
92759367-92787933 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
G to A
at 92785031 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Arginine to Histidine
at position 358
(R358H)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000047199
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000045970]
|
AlphaFold |
Q9QZF2 |
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000045970
AA Change: R358H
PolyPhen 2
Score 0.719 (Sensitivity: 0.86; Specificity: 0.92)
|
SMART Domains |
Protein: ENSMUSP00000047199 Gene: ENSMUSG00000034220 AA Change: R358H
Domain | Start | End | E-Value | Type |
Pfam:Glypican
|
11 |
553 |
6.2e-228 |
PFAM |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000190215
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000190586
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000190677
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000212504
|
Meta Mutation Damage Score |
0.1795 |
Coding Region Coverage |
- 1x: 99.4%
- 3x: 98.7%
- 10x: 96.9%
- 20x: 93.9%
|
Validation Efficiency |
97% (36/37) |
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. [provided by RefSeq, Jul 2008] PHENOTYPE: Homozygous mutant mice exhibit a reduced brain size with mild cerebellar patterning defects, but are otherwise viable and fertile. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 34 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Acaa2 |
G |
T |
18: 74,931,414 (GRCm39) |
M203I |
probably benign |
Het |
Afmid |
T |
A |
11: 117,726,071 (GRCm39) |
|
probably benign |
Het |
Ahnak |
A |
G |
19: 8,987,278 (GRCm39) |
D2854G |
probably damaging |
Het |
Amotl1 |
A |
C |
9: 14,507,854 (GRCm39) |
I31S |
possibly damaging |
Het |
Arf3 |
A |
G |
15: 98,638,984 (GRCm39) |
V91A |
probably benign |
Het |
Atp1b1 |
A |
C |
1: 164,270,829 (GRCm39) |
I50S |
probably benign |
Het |
Baz1a |
A |
T |
12: 54,945,216 (GRCm39) |
S1380T |
probably benign |
Het |
C4b |
T |
A |
17: 34,959,029 (GRCm39) |
T467S |
probably benign |
Het |
Casd1 |
T |
C |
6: 4,635,848 (GRCm39) |
S640P |
probably damaging |
Het |
Col4a1 |
C |
T |
8: 11,258,296 (GRCm39) |
G1396S |
unknown |
Het |
Extl1 |
TGCGTTGCACCGATACCGGG |
TG |
4: 134,084,988 (GRCm39) |
|
probably benign |
Het |
Fhip1a |
G |
T |
3: 85,580,366 (GRCm39) |
P613Q |
probably benign |
Het |
Gm12695 |
C |
A |
4: 96,616,454 (GRCm39) |
E460* |
probably null |
Het |
Gnmt |
A |
G |
17: 47,037,271 (GRCm39) |
L171P |
probably damaging |
Het |
Igsf8 |
C |
T |
1: 172,143,963 (GRCm39) |
R39C |
probably damaging |
Het |
Kdm3b |
T |
A |
18: 34,936,605 (GRCm39) |
C296S |
probably damaging |
Het |
Lama1 |
C |
T |
17: 68,082,860 (GRCm39) |
P1373S |
probably benign |
Het |
Lamc1 |
A |
G |
1: 153,208,020 (GRCm39) |
L89P |
possibly damaging |
Het |
Ltc4s |
T |
G |
11: 50,128,269 (GRCm39) |
|
probably null |
Het |
Met |
A |
T |
6: 17,491,393 (GRCm39) |
I52F |
probably damaging |
Het |
Mterf2 |
G |
A |
10: 84,955,934 (GRCm39) |
T230M |
possibly damaging |
Het |
Mybpc2 |
T |
C |
7: 44,156,311 (GRCm39) |
K834R |
probably benign |
Het |
Npr1 |
A |
T |
3: 90,368,716 (GRCm39) |
I448N |
probably benign |
Het |
Or52u1 |
C |
T |
7: 104,237,545 (GRCm39) |
T178I |
probably damaging |
Het |
Rif1 |
GCCACCA |
GCCA |
2: 52,000,336 (GRCm39) |
|
probably benign |
Het |
Serpini1 |
A |
T |
3: 75,523,934 (GRCm39) |
I181F |
probably damaging |
Het |
Shc3 |
T |
C |
13: 51,634,242 (GRCm39) |
M88V |
probably benign |
Het |
Skint6 |
T |
A |
4: 113,095,555 (GRCm39) |
S35C |
probably damaging |
Het |
Spta1 |
T |
C |
1: 174,072,771 (GRCm39) |
|
probably benign |
Het |
Sult2a2 |
C |
T |
7: 13,468,815 (GRCm39) |
R94* |
probably null |
Het |
Trim9 |
A |
G |
12: 70,295,037 (GRCm39) |
V787A |
probably damaging |
Het |
Ttn |
A |
G |
2: 76,549,367 (GRCm39) |
V31770A |
probably benign |
Het |
Unc5d |
T |
C |
8: 29,249,055 (GRCm39) |
N337D |
possibly damaging |
Het |
Vmn2r7 |
A |
T |
3: 64,624,000 (GRCm39) |
Y107N |
probably benign |
Het |
|
Other mutations in Gpc1 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01411:Gpc1
|
APN |
1 |
92,784,736 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01697:Gpc1
|
APN |
1 |
92,786,132 (GRCm39) |
missense |
possibly damaging |
0.93 |
IGL02282:Gpc1
|
APN |
1 |
92,785,689 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02930:Gpc1
|
APN |
1 |
92,785,021 (GRCm39) |
nonsense |
probably null |
|
IGL03160:Gpc1
|
APN |
1 |
92,785,579 (GRCm39) |
missense |
probably damaging |
1.00 |
PIT4514001:Gpc1
|
UTSW |
1 |
92,785,279 (GRCm39) |
missense |
probably benign |
0.05 |
R0115:Gpc1
|
UTSW |
1 |
92,785,221 (GRCm39) |
missense |
probably damaging |
1.00 |
R0383:Gpc1
|
UTSW |
1 |
92,782,705 (GRCm39) |
missense |
probably damaging |
1.00 |
R0399:Gpc1
|
UTSW |
1 |
92,785,031 (GRCm39) |
missense |
possibly damaging |
0.72 |
R0938:Gpc1
|
UTSW |
1 |
92,785,031 (GRCm39) |
missense |
possibly damaging |
0.72 |
R0942:Gpc1
|
UTSW |
1 |
92,785,031 (GRCm39) |
missense |
possibly damaging |
0.72 |
R2483:Gpc1
|
UTSW |
1 |
92,783,660 (GRCm39) |
missense |
probably benign |
0.35 |
R3749:Gpc1
|
UTSW |
1 |
92,785,304 (GRCm39) |
nonsense |
probably null |
|
R5033:Gpc1
|
UTSW |
1 |
92,784,751 (GRCm39) |
missense |
probably damaging |
0.97 |
R5154:Gpc1
|
UTSW |
1 |
92,784,751 (GRCm39) |
missense |
probably damaging |
0.97 |
R5362:Gpc1
|
UTSW |
1 |
92,782,615 (GRCm39) |
missense |
probably benign |
0.00 |
R5626:Gpc1
|
UTSW |
1 |
92,784,841 (GRCm39) |
critical splice donor site |
probably null |
|
R5693:Gpc1
|
UTSW |
1 |
92,785,621 (GRCm39) |
missense |
probably damaging |
1.00 |
R7268:Gpc1
|
UTSW |
1 |
92,786,093 (GRCm39) |
missense |
possibly damaging |
0.76 |
R7790:Gpc1
|
UTSW |
1 |
92,781,171 (GRCm39) |
missense |
probably benign |
|
R7875:Gpc1
|
UTSW |
1 |
92,782,970 (GRCm39) |
critical splice donor site |
probably null |
|
R9225:Gpc1
|
UTSW |
1 |
92,783,742 (GRCm39) |
missense |
probably damaging |
1.00 |
X0020:Gpc1
|
UTSW |
1 |
92,782,703 (GRCm39) |
missense |
probably benign |
0.00 |
Z1177:Gpc1
|
UTSW |
1 |
92,785,208 (GRCm39) |
missense |
probably damaging |
0.96 |
|
Predicted Primers |
PCR Primer
(F):5'- TGCTGACCTATACCTGTGACTGCTG -3'
(R):5'- TTGGCCTCAGAGACCTGTTGGATG -3'
Sequencing Primer
(F):5'- AAGGTGTgtgggggctg -3'
(R):5'- AGACCTGTTGGATGGCAGTC -3'
|
Posted On |
2013-11-08 |