Incidental Mutation 'R0856:Prl7c1'
ID 82728
Institutional Source Beutler Lab
Gene Symbol Prl7c1
Ensembl Gene ENSMUSG00000060738
Gene Name prolactin family 7, subfamily c, member 1
Synonyms 1600017N11Rik, Prlpo, PLP-O
MMRRC Submission 039035-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.056) question?
Stock # R0856 (G1)
Quality Score 225
Status Not validated
Chromosome 13
Chromosomal Location 27957583-27964829 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 27957717 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 241 (I241T)
Ref Sequence ENSEMBL: ENSMUSP00000072712 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072943]
AlphaFold Q9CRB5
Predicted Effect possibly damaging
Transcript: ENSMUST00000072943
AA Change: I241T

PolyPhen 2 Score 0.842 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000072712
Gene: ENSMUSG00000060738
AA Change: I241T

DomainStartEndE-ValueType
Pfam:Hormone_1 17 242 8.1e-60 PFAM
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 96.9%
  • 20x: 93.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 23 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb11 A T 2: 69,154,262 (GRCm39) S101R probably benign Het
Arhgap32 C A 9: 32,171,516 (GRCm39) P1432Q probably damaging Het
Atp7b A G 8: 22,487,647 (GRCm39) V1134A probably damaging Het
Crtc3 A T 7: 80,245,372 (GRCm39) Y418N probably damaging Het
Cts8 A T 13: 61,398,730 (GRCm39) Y259N probably damaging Het
Defb39 T A 8: 19,102,982 (GRCm39) T38S possibly damaging Het
Depdc7 A G 2: 104,558,437 (GRCm39) S195P probably benign Het
Gykl1 T A 18: 52,828,441 (GRCm39) *550K probably null Het
Kcnip4 A G 5: 48,576,552 (GRCm39) probably null Het
Kif20a T C 18: 34,764,271 (GRCm39) S666P probably benign Het
Klhl32 T C 4: 24,682,092 (GRCm39) D197G probably damaging Het
Men1 A G 19: 6,385,888 (GRCm39) Y133C probably damaging Het
Mtnr1a A G 8: 45,540,870 (GRCm39) E277G possibly damaging Het
Numa1 C A 7: 101,648,155 (GRCm39) Q629K probably damaging Het
Or2a52 T C 6: 43,144,345 (GRCm39) S118P probably damaging Het
P3h3 G T 6: 124,831,896 (GRCm39) D296E probably benign Het
Prr35 T C 17: 26,167,001 (GRCm39) S179G probably benign Het
Rp1 T C 1: 4,414,878 (GRCm39) E2078G probably benign Het
Septin8 A G 11: 53,428,697 (GRCm39) H414R probably benign Het
Tbx20 A G 9: 24,636,908 (GRCm39) M393T probably benign Het
Upf2 A G 2: 5,962,463 (GRCm39) D55G unknown Het
Vit G T 17: 78,927,086 (GRCm39) V344L possibly damaging Het
Vps26a A C 10: 62,304,189 (GRCm39) V176G possibly damaging Het
Other mutations in Prl7c1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01388:Prl7c1 APN 13 27,960,198 (GRCm39) missense probably damaging 1.00
IGL03096:Prl7c1 APN 13 27,957,689 (GRCm39) missense probably damaging 0.96
PIT4458001:Prl7c1 UTSW 13 27,957,741 (GRCm39) missense probably benign
R0566:Prl7c1 UTSW 13 27,962,961 (GRCm39) missense probably damaging 1.00
R0908:Prl7c1 UTSW 13 27,957,717 (GRCm39) missense possibly damaging 0.84
R1585:Prl7c1 UTSW 13 27,962,838 (GRCm39) missense probably damaging 0.99
R4193:Prl7c1 UTSW 13 27,960,261 (GRCm39) missense probably benign 0.01
R4628:Prl7c1 UTSW 13 27,962,065 (GRCm39) missense probably benign
R4728:Prl7c1 UTSW 13 27,960,268 (GRCm39) missense probably benign 0.00
R4873:Prl7c1 UTSW 13 27,957,742 (GRCm39) missense probably benign 0.01
R4875:Prl7c1 UTSW 13 27,957,742 (GRCm39) missense probably benign 0.01
R5714:Prl7c1 UTSW 13 27,962,949 (GRCm39) nonsense probably null
R6353:Prl7c1 UTSW 13 27,957,709 (GRCm39) missense possibly damaging 0.64
R6505:Prl7c1 UTSW 13 27,957,776 (GRCm39) missense probably damaging 1.00
R6878:Prl7c1 UTSW 13 27,962,827 (GRCm39) missense possibly damaging 0.66
R7104:Prl7c1 UTSW 13 27,962,952 (GRCm39) nonsense probably null
R7879:Prl7c1 UTSW 13 27,962,817 (GRCm39) missense probably damaging 1.00
R7896:Prl7c1 UTSW 13 27,962,070 (GRCm39) missense possibly damaging 0.86
R8828:Prl7c1 UTSW 13 27,957,854 (GRCm39) missense probably benign 0.14
R9142:Prl7c1 UTSW 13 27,964,751 (GRCm39) start gained probably benign
R9215:Prl7c1 UTSW 13 27,960,204 (GRCm39) missense probably benign 0.32
R9296:Prl7c1 UTSW 13 27,962,812 (GRCm39) missense probably benign 0.06
R9453:Prl7c1 UTSW 13 27,957,870 (GRCm39) missense probably benign 0.44
Predicted Primers PCR Primer
(F):5'- TGTCGCAATGAAGAGACTTCCCAC -3'
(R):5'- TGGAATGGAGGAGAATACTGACTACCC -3'

Sequencing Primer
(F):5'- ACAAGTTGGCATCACCTGTG -3'
(R):5'- GGAGAATACTGACTACCCTTTATGG -3'
Posted On 2013-11-08