Incidental Mutation 'R0925:Wdfy2'
ID 83163
Institutional Source Beutler Lab
Gene Symbol Wdfy2
Ensembl Gene ENSMUSG00000014547
Gene Name WD repeat and FYVE domain containing 2
Synonyms B130024L21Rik
MMRRC Submission 039072-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.259) question?
Stock # R0925 (G1)
Quality Score 225
Status Not validated
Chromosome 14
Chromosomal Location 63075127-63198958 bp(+) (GRCm39)
Type of Mutation critical splice acceptor site
DNA Base Change (assembly) A to T at 63167675 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000014691 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000014691] [ENSMUST00000014691]
AlphaFold Q8BUB4
Predicted Effect probably null
Transcript: ENSMUST00000014691
SMART Domains Protein: ENSMUSP00000014691
Gene: ENSMUSG00000014547

DomainStartEndE-ValueType
WD40 13 52 1.92e0 SMART
Blast:WD40 56 96 1e-21 BLAST
WD40 103 142 1.43e1 SMART
Blast:WD40 145 183 2e-16 BLAST
WD40 188 227 6.68e-10 SMART
WD40 231 270 5.31e-4 SMART
FYVE 276 353 1.04e-22 SMART
WD40 355 394 7e-4 SMART
Predicted Effect probably null
Transcript: ENSMUST00000014691
SMART Domains Protein: ENSMUSP00000014691
Gene: ENSMUSG00000014547

DomainStartEndE-ValueType
WD40 13 52 1.92e0 SMART
Blast:WD40 56 96 1e-21 BLAST
WD40 103 142 1.43e1 SMART
Blast:WD40 145 183 2e-16 BLAST
WD40 188 227 6.68e-10 SMART
WD40 231 270 5.31e-4 SMART
FYVE 276 353 1.04e-22 SMART
WD40 355 394 7e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000224948
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.9%
  • 10x: 97.5%
  • 20x: 95.7%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that contains two WD domains and an FYVE zinc finger region. The function of this gene is unknown. An alternatively spliced transcript variant of this gene may exist. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam34l T C 8: 44,079,340 (GRCm39) I295V probably benign Het
Adam5 T C 8: 25,302,441 (GRCm39) Q101R probably benign Het
C2cd4c T C 10: 79,448,584 (GRCm39) N188D probably benign Het
Cdc27 A G 11: 104,416,875 (GRCm39) probably null Het
Cdh11 T A 8: 103,361,356 (GRCm39) I661L probably damaging Het
Cimip1 T A 2: 173,367,867 (GRCm39) S47T probably benign Het
Csmd1 A G 8: 16,760,634 (GRCm39) I167T probably benign Het
Dennd3 T G 15: 73,405,284 (GRCm39) F346V probably damaging Het
Dis3l A T 9: 64,248,412 (GRCm39) M1K probably null Het
Dnajb6 A T 5: 29,957,398 (GRCm39) K60I probably damaging Het
Dock10 T A 1: 80,514,657 (GRCm39) H1421L probably benign Het
Elmod3 A T 6: 72,545,921 (GRCm39) C274S probably damaging Het
Eme1 T C 11: 94,541,558 (GRCm39) E88G probably damaging Het
Fam227a A T 15: 79,505,006 (GRCm39) M475K probably benign Het
Frem2 T C 3: 53,561,394 (GRCm39) I1038V probably benign Het
Gabpb1 T A 2: 126,494,185 (GRCm39) N147Y probably damaging Het
Gmnc A G 16: 26,779,173 (GRCm39) L278P probably benign Het
Gpr153 A G 4: 152,366,331 (GRCm39) T299A probably benign Het
H2-M11 T C 17: 36,858,353 (GRCm39) V49A probably benign Het
Hemgn T A 4: 46,397,049 (GRCm39) K62N probably damaging Het
Hormad2 G A 11: 4,377,297 (GRCm39) T47M probably damaging Het
Iqcf6 A G 9: 106,504,500 (GRCm39) T55A probably benign Het
Itgam T C 7: 127,711,410 (GRCm39) F705L probably benign Het
Klk1 T A 7: 43,878,240 (GRCm39) probably null Het
Myo1f A T 17: 33,797,107 (GRCm39) I123F probably damaging Het
Nup58 T C 14: 60,457,590 (GRCm39) T538A probably damaging Het
Or52j3 T A 7: 102,836,030 (GRCm39) L74* probably null Het
Or5p81 C T 7: 108,267,400 (GRCm39) T259I probably benign Het
Pdzd2 C T 15: 12,399,356 (GRCm39) R790H probably damaging Het
Pigv T C 4: 133,389,960 (GRCm39) K74R probably benign Het
Prmt8 T C 6: 127,674,776 (GRCm39) K284R probably benign Het
Rsl1d1 A T 16: 11,017,553 (GRCm39) Y138N probably damaging Het
Scara5 AC ACC 14: 66,000,167 (GRCm39) probably benign Het
Smc4 T A 3: 68,913,548 (GRCm39) probably benign Het
Spta1 G A 1: 174,001,992 (GRCm39) V41I possibly damaging Het
Tdrd7 C A 4: 46,025,758 (GRCm39) N859K probably damaging Het
Vps13d T G 4: 144,883,121 (GRCm39) D824A probably damaging Het
Other mutations in Wdfy2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00228:Wdfy2 APN 14 63,181,526 (GRCm39) missense probably damaging 0.98
IGL02374:Wdfy2 APN 14 63,171,833 (GRCm39) missense probably benign 0.06
IGL03039:Wdfy2 APN 14 63,186,169 (GRCm39) missense probably benign 0.36
Special_k UTSW 14 63,186,115 (GRCm39) missense probably damaging 1.00
R0391:Wdfy2 UTSW 14 63,162,582 (GRCm39) missense possibly damaging 0.83
R1711:Wdfy2 UTSW 14 63,181,546 (GRCm39) missense probably benign 0.00
R4299:Wdfy2 UTSW 14 63,162,589 (GRCm39) nonsense probably null
R5372:Wdfy2 UTSW 14 63,192,334 (GRCm39) missense probably damaging 1.00
R6418:Wdfy2 UTSW 14 63,162,582 (GRCm39) missense probably benign 0.32
R6466:Wdfy2 UTSW 14 63,186,115 (GRCm39) missense probably damaging 1.00
R7055:Wdfy2 UTSW 14 63,137,748 (GRCm39) missense probably benign 0.00
R7977:Wdfy2 UTSW 14 63,189,380 (GRCm39) missense possibly damaging 0.57
R7987:Wdfy2 UTSW 14 63,189,380 (GRCm39) missense possibly damaging 0.57
X0019:Wdfy2 UTSW 14 63,186,192 (GRCm39) nonsense probably null
Z1176:Wdfy2 UTSW 14 63,171,782 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGTAACACTGGGCGCAGTTTCC -3'
(R):5'- GAACTATGTCACAGCAGTCAGCAGG -3'

Sequencing Primer
(F):5'- GGGTATAACACCAGGCTGC -3'
(R):5'- CGAGCCTTAAGAAGTTCTCTGAG -3'
Posted On 2013-11-08