Mutagenetix > Incidental Mutation

Incidental Mutation 'R0926:Or4f7'

83183

Institutional Source

Beutler Lab

Gene Symbol

Or4f7

Ensembl Gene

ENSMUSG00000093804

Gene Name

olfactory receptor family 4 subfamily F member 7

Synonyms

Olfr276, GA_x6K02T2Q125-72882187-72881249, MOR245-7, MOR245-7, MOR245-28_p, GA_x6K02T2N82Q-3465-3764, Olfr1303

MMRRC Submission

039073-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.122) question?

Stock #

R0926 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

111644131-111645069 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 111644892 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Histidine at position 60 (Y60H)

Ref Sequence

ENSEMBL: ENSMUSP00000149015 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000099609] [ENSMUST00000216114]

AlphaFold

A2AVW1

Predicted Effect

probably damaging
Transcript: ENSMUST00000099609
AA Change: Y60H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000097204
Gene: ENSMUSG00000093804
AA Change: Y60H

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	305	2.3e-43	PFAM
Pfam:7TM_GPCR_Srsx	35	302	2.5e-6	PFAM
Pfam:7tm_1	41	287	2.4e-19	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000216114
AA Change: Y60H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Meta Mutation Damage Score

0.3114

Coding Region Coverage

1x: 99.4%
3x: 98.8%
10x: 97.4%
20x: 95.2%

Validation Efficiency

98% (61/62)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 60 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700017B05Rik	T	C	9: 57,164,832 (GRCm39)	D514G	probably damaging	Het
Acbd7	A	T	2: 3,341,478 (GRCm39)	I41F	possibly damaging	Het
Actr8	G	T	14: 29,709,181 (GRCm39)	V262L	probably benign	Het
Anp32e	A	G	3: 95,844,454 (GRCm39)	D108G	probably damaging	Het
Banp	G	A	8: 122,747,294 (GRCm39)	G448S	probably benign	Het
Camsap3	G	A	8: 3,637,960 (GRCm39)		probably null	Het
Cd22	C	A	7: 30,568,934 (GRCm39)		probably null	Het
Cfap58	A	T	19: 47,951,001 (GRCm39)	Q454L	probably damaging	Het
Cntn4	C	T	6: 106,632,542 (GRCm39)	T522I	probably benign	Het
Col11a1	G	A	3: 113,883,829 (GRCm39)	D233N	unknown	Het
Csmd1	G	T	8: 16,083,590 (GRCm39)		probably null	Het
Csmd3	T	A	15: 47,840,429 (GRCm39)	Y946F	probably damaging	Het
D5Ertd579e	G	T	5: 36,830,210 (GRCm39)	P38Q	probably damaging	Het
Dnal4	T	C	15: 79,646,226 (GRCm39)	T93A	probably benign	Het
Dsp	A	T	13: 38,367,194 (GRCm39)	D614V	probably damaging	Het
Fcgr1	A	T	3: 96,199,682 (GRCm39)	I75N	possibly damaging	Het
Fgd6	T	A	10: 93,970,909 (GRCm39)	Y1229N	probably benign	Het
Fhip2a	G	A	19: 57,369,522 (GRCm39)	A383T	probably damaging	Het
Frmpd1	T	G	4: 45,268,497 (GRCm39)	L214R	probably damaging	Het
Gapvd1	A	T	2: 34,602,337 (GRCm39)	D603E	probably damaging	Het
H2-M9	A	G	17: 36,952,665 (GRCm39)	V127A	probably damaging	Het
Herc2	T	A	7: 55,782,296 (GRCm39)	S1328T	possibly damaging	Het
Ica1l	T	C	1: 60,045,456 (GRCm39)	N269S	probably benign	Het
Il18r1	T	C	1: 40,526,188 (GRCm39)	Y245H	probably damaging	Het
Il6ra	A	T	3: 89,794,376 (GRCm39)	V195E	probably damaging	Het
Inpp5j	A	G	11: 3,451,439 (GRCm39)		probably benign	Het
Isy1	T	C	6: 87,796,125 (GRCm39)	T271A	probably benign	Het
Klra9	T	C	6: 130,155,993 (GRCm39)	Y254C	probably damaging	Het
Ly6e	T	G	15: 74,830,219 (GRCm39)	S73A	probably damaging	Het
Mcmdc2	T	A	1: 9,990,801 (GRCm39)	L326*	probably null	Het
Muc4	G	A	16: 32,576,570 (GRCm39)		probably benign	Het
Myh3	A	G	11: 66,981,340 (GRCm39)		probably null	Het
Ndor1	G	A	2: 25,138,360 (GRCm39)	H409Y	probably benign	Het
Nwd2	A	G	5: 63,965,234 (GRCm39)	D1606G	probably damaging	Het
Or2t44	A	G	11: 58,677,935 (GRCm39)	N292D	probably damaging	Het
Or3a1d	G	A	11: 74,238,132 (GRCm39)	R93C	probably benign	Het
Or51f1e	T	C	7: 102,747,092 (GRCm39)	L48P	probably damaging	Het
Or5b99	A	T	19: 12,976,554 (GRCm39)	D68V	probably damaging	Het
Or5h18	A	G	16: 58,848,051 (GRCm39)	I73T	possibly damaging	Het
Or5l13	A	T	2: 87,780,266 (GRCm39)	F104I	probably damaging	Het
Paox	C	A	7: 139,713,951 (GRCm39)	T237K	probably damaging	Het
Pcmtd1	T	A	1: 7,231,243 (GRCm39)	L4I	probably damaging	Het
Pfkl	T	A	10: 77,836,523 (GRCm39)	T165S	probably damaging	Het
Pik3ap1	A	G	19: 41,290,964 (GRCm39)	S523P	probably benign	Het
Pitpnm1	A	G	19: 4,162,338 (GRCm39)	D1056G	probably damaging	Het
Pitpnm2	G	A	5: 124,269,272 (GRCm39)	T450I	probably benign	Het
Pou2f3	T	C	9: 43,058,198 (GRCm39)	D37G	probably damaging	Het
Prdm5	A	G	6: 65,860,531 (GRCm39)	H221R	probably damaging	Het
Pwp1	T	A	10: 85,712,378 (GRCm39)	I72N	probably damaging	Het
Rhou	A	G	8: 124,387,715 (GRCm39)	E149G	probably damaging	Het
She	A	G	3: 89,758,901 (GRCm39)		probably benign	Het
Slc26a9	A	C	1: 131,680,954 (GRCm39)	H121P	probably benign	Het
Spag17	A	G	3: 99,979,432 (GRCm39)	D1431G	probably benign	Het
Trpm3	A	T	19: 22,965,407 (GRCm39)	D1634V	probably benign	Het
Ttn	A	G	2: 76,627,571 (GRCm39)		probably benign	Het
Zc3h14	T	A	12: 98,724,849 (GRCm39)	D170E	possibly damaging	Het
Zcrb1	T	C	15: 93,289,409 (GRCm39)	K51E	probably damaging	Het
Zfp110	C	T	7: 12,583,808 (GRCm39)	Q819*	probably null	Het
Zfp616	A	G	11: 73,976,644 (GRCm39)	N971S	probably benign	Het
Zfp827	A	T	8: 79,844,821 (GRCm39)	T664S	probably benign	Het

Other mutations in Or4f7

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00163:Or4f7	APN	2	111,644,126 (GRCm39)	utr 3 prime	probably benign
IGL02442:Or4f7	APN	2	111,644,336 (GRCm39)	missense	probably benign	0.26
IGL02563:Or4f7	APN	2	111,644,162 (GRCm39)	missense	probably benign
IGL03064:Or4f7	APN	2	111,644,768 (GRCm39)	missense	possibly damaging	0.86
R0081:Or4f7	UTSW	2	111,644,213 (GRCm39)	missense	probably damaging	1.00
R0139:Or4f7	UTSW	2	111,644,699 (GRCm39)	missense	possibly damaging	0.54
R0624:Or4f7	UTSW	2	111,645,056 (GRCm39)	missense	probably damaging	1.00
R1436:Or4f7	UTSW	2	111,644,906 (GRCm39)	missense	probably damaging	1.00
R2099:Or4f7	UTSW	2	111,644,177 (GRCm39)	missense	probably benign	0.18
R5255:Or4f7	UTSW	2	111,644,523 (GRCm39)	missense	probably benign	0.02
R6034:Or4f7	UTSW	2	111,644,702 (GRCm39)	missense	probably damaging	1.00
R6034:Or4f7	UTSW	2	111,644,702 (GRCm39)	missense	probably damaging	1.00
R6101:Or4f7	UTSW	2	111,644,598 (GRCm39)	missense	probably benign	0.00
R6385:Or4f7	UTSW	2	111,644,964 (GRCm39)	missense	probably benign
R6489:Or4f7	UTSW	2	111,644,405 (GRCm39)	missense	probably damaging	1.00
R6978:Or4f7	UTSW	2	111,644,155 (GRCm39)	missense	probably benign	0.03
R7410:Or4f7	UTSW	2	111,644,271 (GRCm39)	missense	probably benign	0.00
R8507:Or4f7	UTSW	2	111,645,051 (GRCm39)	missense	probably benign	0.23
R8897:Or4f7	UTSW	2	111,644,576 (GRCm39)	missense	probably benign	0.01
R9084:Or4f7	UTSW	2	111,644,996 (GRCm39)	missense	probably damaging	1.00
R9096:Or4f7	UTSW	2	111,644,196 (GRCm39)	nonsense	probably null
R9097:Or4f7	UTSW	2	111,644,196 (GRCm39)	nonsense	probably null
R9784:Or4f7	UTSW	2	111,644,604 (GRCm39)	missense	probably damaging	1.00
Z1176:Or4f7	UTSW	2	111,644,379 (GRCm39)	missense	probably benign	0.22

Predicted Primers

PCR Primer
(F):5'- AGGTAGTGCAGGGGCTTACATATGG -3'
(R):5'- TTGGCTGAACCAATGGATGGGG -3'

Sequencing Primer
(F):5'- TCAAATGCCATGGCCACA -3'
(R):5'- CCAATGGATGGGGAGAACCAC -3'

Posted On

2013-11-08