Incidental Mutation 'R0904:Slfn10-ps'
| ID |
83259 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Slfn10-ps
|
| Ensembl Gene |
ENSMUSG00000072621 |
| Gene Name |
schlafen 10, pseudogene |
| Synonyms |
|
| MMRRC Submission |
039062-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.073)
|
| Stock # |
R0904 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
11 |
| Chromosomal Location |
82919681-82926992 bp(-) (GRCm39) |
| Type of Mutation |
unclassified |
| DNA Base Change (assembly) |
T to C
at 82926235 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Gene Model |
predicted gene model for transcript(s):
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000100716
|
| SMART Domains |
Protein: ENSMUSP00000098282
Gene: ENSMUSG00000072621
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:AlbA_2
|
142 |
278 |
1.3e-13 |
PFAM |
|
Pfam:DUF2075
|
529 |
697 |
1.6e-7 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000152760
|
| SMART Domains |
Protein: ENSMUSP00000130353
Gene: ENSMUSG00000072621
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:AAA_4
|
142 |
280 |
1.8e-14 |
PFAM |
|
Pfam:DUF2075
|
529 |
693 |
1.8e-8 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000185158
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000215473
|
| Meta Mutation Damage Score |
0.3555 |
| Coding Region Coverage |
- 1x: 99.4%
- 3x: 98.8%
- 10x: 97.2%
- 20x: 94.7%
|
| Validation Efficiency |
89% (34/38) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 35 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700011L22Rik |
A |
G |
8: 79,975,118 (GRCm39) |
|
probably benign |
Het |
| Abca13 |
T |
C |
11: 9,248,740 (GRCm39) |
V2829A |
probably benign |
Het |
| Adk |
G |
T |
14: 21,142,496 (GRCm39) |
D26Y |
probably damaging |
Het |
| Bpifb9a |
T |
C |
2: 154,106,145 (GRCm39) |
|
probably benign |
Het |
| Dap |
G |
A |
15: 31,272,526 (GRCm39) |
|
probably benign |
Het |
| Eqtn |
A |
T |
4: 94,795,892 (GRCm39) |
S270T |
probably benign |
Het |
| Fam193a |
A |
G |
5: 34,619,487 (GRCm39) |
D764G |
probably damaging |
Het |
| Fbxl6 |
A |
T |
15: 76,421,283 (GRCm39) |
|
probably null |
Het |
| Gtf3c1 |
A |
T |
7: 125,268,014 (GRCm39) |
|
probably benign |
Het |
| H2-D1 |
G |
C |
17: 35,482,837 (GRCm39) |
M122I |
probably benign |
Het |
| Lgr6 |
C |
T |
1: 134,921,748 (GRCm39) |
A199T |
probably damaging |
Het |
| Map1s |
C |
A |
8: 71,366,832 (GRCm39) |
P579Q |
probably damaging |
Het |
| Mapk10 |
A |
G |
5: 103,135,146 (GRCm39) |
|
probably benign |
Het |
| Mllt6 |
C |
G |
11: 97,555,824 (GRCm39) |
C51W |
probably damaging |
Het |
| Mzf1 |
C |
A |
7: 12,786,698 (GRCm39) |
R124L |
possibly damaging |
Het |
| Naip2 |
T |
C |
13: 100,298,362 (GRCm39) |
E558G |
probably benign |
Het |
| Naip2 |
C |
T |
13: 100,298,368 (GRCm39) |
G556D |
probably benign |
Het |
| Neurod2 |
G |
T |
11: 98,218,147 (GRCm39) |
T339K |
probably benign |
Het |
| Nfya |
G |
A |
17: 48,702,815 (GRCm39) |
Q29* |
probably null |
Het |
| Nipbl |
A |
T |
15: 8,391,202 (GRCm39) |
D257E |
probably benign |
Het |
| Pate5 |
T |
C |
9: 35,750,366 (GRCm39) |
D102G |
probably damaging |
Het |
| Pex5 |
G |
A |
6: 124,376,896 (GRCm39) |
|
probably benign |
Het |
| Pramel47 |
A |
C |
5: 95,489,186 (GRCm39) |
T210P |
probably damaging |
Het |
| Prx |
T |
A |
7: 27,217,719 (GRCm39) |
F879Y |
probably damaging |
Het |
| Resf1 |
G |
A |
6: 149,229,767 (GRCm39) |
A938T |
probably damaging |
Het |
| Scai |
G |
A |
2: 38,965,164 (GRCm39) |
T560M |
possibly damaging |
Het |
| Spdye4b |
A |
G |
5: 143,181,423 (GRCm39) |
|
probably benign |
Het |
| Ss18l1 |
A |
G |
2: 179,701,147 (GRCm39) |
Y287C |
probably damaging |
Het |
| Tpbg |
C |
A |
9: 85,726,617 (GRCm39) |
F195L |
unknown |
Het |
| Trbv16 |
T |
C |
6: 41,128,781 (GRCm39) |
|
probably benign |
Het |
| Unc5c |
A |
G |
3: 141,509,601 (GRCm39) |
T620A |
probably benign |
Het |
| Vangl1 |
A |
G |
3: 102,091,310 (GRCm39) |
S259P |
probably damaging |
Het |
| Vmn1r52 |
T |
A |
6: 90,156,446 (GRCm39) |
M71K |
probably damaging |
Het |
| Vmn2r23 |
A |
T |
6: 123,719,094 (GRCm39) |
I816F |
probably damaging |
Het |
| Zfp268 |
T |
C |
4: 145,348,745 (GRCm39) |
Y61H |
possibly damaging |
Het |
|
| Other mutations in Slfn10-ps |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00773:Slfn10-ps
|
APN |
11 |
82,926,355 (GRCm39) |
unclassified |
noncoding transcript |
|
|
IGL00826:Slfn10-ps
|
APN |
11 |
82,926,085 (GRCm39) |
unclassified |
noncoding transcript |
|
|
IGL01022:Slfn10-ps
|
APN |
11 |
82,926,353 (GRCm39) |
unclassified |
noncoding transcript |
|
|
IGL01409:Slfn10-ps
|
APN |
11 |
82,926,322 (GRCm39) |
unclassified |
noncoding transcript |
|
|
IGL01664:Slfn10-ps
|
APN |
11 |
82,926,761 (GRCm39) |
unclassified |
noncoding transcript |
|
|
IGL01700:Slfn10-ps
|
APN |
11 |
82,919,938 (GRCm39) |
unclassified |
noncoding transcript |
|
|
IGL02093:Slfn10-ps
|
APN |
11 |
82,923,016 (GRCm39) |
unclassified |
noncoding transcript |
|
|
IGL02253:Slfn10-ps
|
APN |
11 |
82,919,890 (GRCm39) |
unclassified |
noncoding transcript |
|
|
IGL02364:Slfn10-ps
|
APN |
11 |
82,923,117 (GRCm39) |
unclassified |
noncoding transcript |
|
|
IGL02466:Slfn10-ps
|
APN |
11 |
82,921,090 (GRCm39) |
unclassified |
noncoding transcript |
|
|
IGL02636:Slfn10-ps
|
APN |
11 |
82,920,971 (GRCm39) |
unclassified |
noncoding transcript |
|
|
R0055:Slfn10-ps
|
UTSW |
11 |
82,921,126 (GRCm39) |
unclassified |
noncoding transcript |
|
|
R0055:Slfn10-ps
|
UTSW |
11 |
82,921,126 (GRCm39) |
unclassified |
noncoding transcript |
|
|
R0069:Slfn10-ps
|
UTSW |
11 |
82,926,368 (GRCm39) |
unclassified |
noncoding transcript |
|
|
R0069:Slfn10-ps
|
UTSW |
11 |
82,926,368 (GRCm39) |
unclassified |
noncoding transcript |
|
|
R0164:Slfn10-ps
|
UTSW |
11 |
82,926,128 (GRCm39) |
unclassified |
noncoding transcript |
|
|
R0362:Slfn10-ps
|
UTSW |
11 |
82,926,600 (GRCm39) |
unclassified |
noncoding transcript |
|
|
R0382:Slfn10-ps
|
UTSW |
11 |
82,920,360 (GRCm39) |
unclassified |
noncoding transcript |
|
|
R0597:Slfn10-ps
|
UTSW |
11 |
82,926,479 (GRCm39) |
unclassified |
noncoding transcript |
|
|
R0812:Slfn10-ps
|
UTSW |
11 |
82,926,388 (GRCm39) |
unclassified |
noncoding transcript |
|
|
R1552:Slfn10-ps
|
UTSW |
11 |
82,920,676 (GRCm39) |
unclassified |
noncoding transcript |
|
|
R1703:Slfn10-ps
|
UTSW |
11 |
82,920,869 (GRCm39) |
unclassified |
noncoding transcript |
|
|
R2127:Slfn10-ps
|
UTSW |
11 |
82,921,168 (GRCm39) |
unclassified |
noncoding transcript |
|
|
R2151:Slfn10-ps
|
UTSW |
11 |
82,926,511 (GRCm39) |
unclassified |
noncoding transcript |
|
|
R2302:Slfn10-ps
|
UTSW |
11 |
82,919,756 (GRCm39) |
unclassified |
noncoding transcript |
|
|
R3114:Slfn10-ps
|
UTSW |
11 |
82,919,955 (GRCm39) |
unclassified |
noncoding transcript |
|
|
R4293:Slfn10-ps
|
UTSW |
11 |
82,926,260 (GRCm39) |
unclassified |
noncoding transcript |
|
|
R4929:Slfn10-ps
|
UTSW |
11 |
82,920,345 (GRCm39) |
unclassified |
noncoding transcript |
|
|
R4970:Slfn10-ps
|
UTSW |
11 |
82,921,207 (GRCm39) |
unclassified |
noncoding transcript |
|
|
R5083:Slfn10-ps
|
UTSW |
11 |
82,921,341 (GRCm39) |
unclassified |
noncoding transcript |
|
|
R5290:Slfn10-ps
|
UTSW |
11 |
82,919,851 (GRCm39) |
unclassified |
noncoding transcript |
|
|
R5306:Slfn10-ps
|
UTSW |
11 |
82,926,355 (GRCm39) |
unclassified |
noncoding transcript |
|
|
R5444:Slfn10-ps
|
UTSW |
11 |
82,926,113 (GRCm39) |
unclassified |
noncoding transcript |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TCTGAGAACACTGCACAGCAGAAAG -3'
(R):5'- CAGGAGCCATGTATCAGAACAGCC -3'
Sequencing Primer
(F):5'- CAGCAGAAAGGCTCTACTTTG -3'
(R):5'- ATGTATCAGAACAGCCTTGAAAC -3'
|
| Posted On |
2013-11-08 |
Incidental Mutation