Incidental Mutation 'R0906:Slc2a5'
ID 83318
Institutional Source Beutler Lab
Gene Symbol Slc2a5
Ensembl Gene ENSMUSG00000028976
Gene Name solute carrier family 2 (facilitated glucose transporter), member 5
Synonyms GLUT5
MMRRC Submission 039064-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.080) question?
Stock # R0906 (G1)
Quality Score 211
Status Validated
Chromosome 4
Chromosomal Location 150203801-150228625 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 150227287 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 401 (I401T)
Ref Sequence ENSEMBL: ENSMUSP00000030826 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030826]
AlphaFold Q9WV38
Predicted Effect probably benign
Transcript: ENSMUST00000030826
AA Change: I401T

PolyPhen 2 Score 0.210 (Sensitivity: 0.92; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000030826
Gene: ENSMUSG00000028976
AA Change: I401T

DomainStartEndE-ValueType
Pfam:MFS_1 16 397 1e-19 PFAM
Pfam:Sugar_tr 19 474 2.1e-138 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000132426
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136610
Predicted Effect noncoding transcript
Transcript: ENSMUST00000151504
Meta Mutation Damage Score 0.6386 question?
Coding Region Coverage
  • 1x: 99.5%
  • 3x: 99.0%
  • 10x: 97.8%
  • 20x: 96.3%
Validation Efficiency 100% (33/33)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a fructose transporter responsible for fructose uptake by the small intestine. The encoded protein also is necessary for the increase in blood pressure due to high dietary fructose consumption. [provided by RefSeq, Jun 2016]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit normal cochlear morphology and physiology with no detectable alterations in outer hair cell morphology, electromotility or nonlinear capacitance. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
AA986860 T A 1: 130,665,430 (GRCm39) probably benign Het
Atp7b T C 8: 22,517,842 (GRCm39) H332R probably benign Het
Bace2 C T 16: 97,158,141 (GRCm39) P47L possibly damaging Het
Cyp2c39 A G 19: 39,499,315 (GRCm39) M1V probably null Het
Dcbld2 A G 16: 58,275,610 (GRCm39) E442G probably damaging Het
Gm14496 A G 2: 181,642,308 (GRCm39) T660A probably damaging Het
Gm4945 A C 17: 47,353,796 (GRCm39) noncoding transcript Het
Gm6729 T C 10: 86,376,456 (GRCm39) noncoding transcript Het
Golga1 G A 2: 38,937,655 (GRCm39) R204W probably damaging Het
Guf1 T C 5: 69,723,729 (GRCm39) I348T probably damaging Het
Htra4 T A 8: 25,527,160 (GRCm39) I212L probably benign Het
Itih5 G A 2: 10,253,999 (GRCm39) R750Q probably benign Het
Lgalsl2 T C 7: 5,362,828 (GRCm39) I153T probably damaging Het
Lgr6 C T 1: 134,921,748 (GRCm39) A199T probably damaging Het
Naip2 C T 13: 100,298,368 (GRCm39) G556D probably benign Het
Naip2 T C 13: 100,298,362 (GRCm39) E558G probably benign Het
Nsd1 T C 13: 55,425,403 (GRCm39) V1520A probably benign Het
Nuak1 C T 10: 84,211,144 (GRCm39) V315I probably damaging Het
Nup205 G T 6: 35,213,827 (GRCm39) G1740C probably damaging Het
Or1r1 G C 11: 73,874,685 (GRCm39) L250V probably damaging Het
Pclo T C 5: 14,726,700 (GRCm39) probably benign Het
Pik3r6 T C 11: 68,426,927 (GRCm39) probably benign Het
Pikfyve T A 1: 65,292,556 (GRCm39) F1336I probably damaging Het
Pla2r1 A G 2: 60,345,291 (GRCm39) I355T possibly damaging Het
Rgs22 A T 15: 36,104,048 (GRCm39) probably benign Het
Sec63 T A 10: 42,677,924 (GRCm39) M312K probably damaging Het
Slc9a8 G T 2: 167,276,787 (GRCm39) probably benign Het
Stab1 T C 14: 30,867,206 (GRCm39) E1718G probably benign Het
Terb1 A T 8: 105,179,268 (GRCm39) I640N probably damaging Het
Tmem217 A G 17: 29,745,490 (GRCm39) L80P probably damaging Het
Topbp1 C T 9: 103,205,792 (GRCm39) P810L probably benign Het
Ttbk2 G A 2: 120,614,262 (GRCm39) R151C probably damaging Het
Vmn2r88 T G 14: 51,655,666 (GRCm39) L626R probably damaging Het
Other mutations in Slc2a5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00819:Slc2a5 APN 4 150,210,113 (GRCm39) missense probably damaging 1.00
IGL01071:Slc2a5 APN 4 150,205,190 (GRCm39) utr 5 prime probably benign
IGL01977:Slc2a5 APN 4 150,226,675 (GRCm39) missense probably damaging 0.97
IGL03271:Slc2a5 APN 4 150,220,040 (GRCm39) missense probably damaging 1.00
BB006:Slc2a5 UTSW 4 150,223,942 (GRCm39) missense probably benign 0.39
BB016:Slc2a5 UTSW 4 150,223,942 (GRCm39) missense probably benign 0.39
R0760:Slc2a5 UTSW 4 150,224,124 (GRCm39) missense probably benign
R1099:Slc2a5 UTSW 4 150,226,636 (GRCm39) missense probably benign 0.01
R1809:Slc2a5 UTSW 4 150,227,514 (GRCm39) missense probably damaging 1.00
R2099:Slc2a5 UTSW 4 150,227,634 (GRCm39) nonsense probably null
R2152:Slc2a5 UTSW 4 150,210,095 (GRCm39) missense probably damaging 1.00
R2253:Slc2a5 UTSW 4 150,224,447 (GRCm39) missense possibly damaging 0.78
R2696:Slc2a5 UTSW 4 150,205,203 (GRCm39) missense probably benign
R4835:Slc2a5 UTSW 4 150,224,462 (GRCm39) missense probably benign 0.06
R4926:Slc2a5 UTSW 4 150,205,199 (GRCm39) nonsense probably null
R5123:Slc2a5 UTSW 4 150,224,262 (GRCm39) nonsense probably null
R5397:Slc2a5 UTSW 4 150,224,280 (GRCm39) splice site probably null
R6209:Slc2a5 UTSW 4 150,227,557 (GRCm39) missense probably benign 0.00
R6342:Slc2a5 UTSW 4 150,223,983 (GRCm39) missense possibly damaging 0.93
R6547:Slc2a5 UTSW 4 150,220,076 (GRCm39) missense possibly damaging 0.94
R7340:Slc2a5 UTSW 4 150,224,439 (GRCm39) missense probably benign 0.44
R7507:Slc2a5 UTSW 4 150,210,107 (GRCm39) missense probably damaging 1.00
R7537:Slc2a5 UTSW 4 150,213,526 (GRCm39) missense possibly damaging 0.89
R7572:Slc2a5 UTSW 4 150,226,642 (GRCm39) missense probably benign 0.33
R7751:Slc2a5 UTSW 4 150,227,591 (GRCm39) missense probably damaging 1.00
R7929:Slc2a5 UTSW 4 150,223,942 (GRCm39) missense probably benign 0.39
R8058:Slc2a5 UTSW 4 150,227,590 (GRCm39) missense probably damaging 1.00
R8318:Slc2a5 UTSW 4 150,224,115 (GRCm39) missense possibly damaging 0.90
R8477:Slc2a5 UTSW 4 150,210,119 (GRCm39) missense probably benign 0.09
R8498:Slc2a5 UTSW 4 150,210,590 (GRCm39) missense probably benign 0.01
R8975:Slc2a5 UTSW 4 150,224,270 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTTGTAAGCCACTGTGCCGTCC -3'
(R):5'- CAATGAATGTCCTGCCCTTGGTCTC -3'

Sequencing Primer
(F):5'- ACTGTGCCGTCCAGGAAAG -3'
(R):5'- TCTCTGGGACGACCATGAAG -3'
Posted On 2013-11-08