Incidental Mutation 'R0909:Scg2'
ID 83411
Institutional Source Beutler Lab
Gene Symbol Scg2
Ensembl Gene ENSMUSG00000050711
Gene Name secretogranin II
Synonyms SgII, Chgc
MMRRC Submission 039067-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0909 (G1)
Quality Score 225
Status Not validated
Chromosome 1
Chromosomal Location 79412386-79417837 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 79413499 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Leucine at position 368 (Q368L)
Ref Sequence ENSEMBL: ENSMUSP00000139740 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049972] [ENSMUST00000185234]
AlphaFold Q03517
Predicted Effect possibly damaging
Transcript: ENSMUST00000049972
AA Change: Q408L

PolyPhen 2 Score 0.528 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000062556
Gene: ENSMUSG00000050711
AA Change: Q408L

DomainStartEndE-ValueType
Pfam:Granin 27 614 7.2e-235 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000185234
AA Change: Q368L

PolyPhen 2 Score 0.742 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000139740
Gene: ENSMUSG00000050711
AA Change: Q368L

DomainStartEndE-ValueType
Pfam:Granin 27 319 1.4e-123 PFAM
Pfam:Granin 316 574 7.1e-91 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.4%
  • 20x: 91.5%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Studies in rodents suggest that the full-length protein, secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. The full-length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotaxic effects on specific cell types, and EM66, whose function is unknown. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1810055G02Rik T A 19: 3,765,788 (GRCm39) M21K probably benign Het
Ap3s2 T C 7: 79,530,266 (GRCm39) N183S probably benign Het
Cd109 A G 9: 78,543,755 (GRCm39) I100V probably benign Het
Cep170b A G 12: 112,698,473 (GRCm39) K77R probably null Het
Chmp5 C A 4: 40,960,968 (GRCm39) N202K probably benign Het
Cnbd1 A T 4: 19,122,444 (GRCm39) L15I probably benign Het
Ehmt2 T C 17: 35,125,480 (GRCm39) V542A possibly damaging Het
Exosc9 A T 3: 36,608,853 (GRCm39) I151F probably damaging Het
Eya2 A G 2: 165,596,413 (GRCm39) N308S probably benign Het
Fbxw21 C A 9: 108,985,476 (GRCm39) A101S possibly damaging Het
Frem3 A C 8: 81,390,035 (GRCm39) N1762T probably benign Het
H2-DMb2 C A 17: 34,367,783 (GRCm39) T68N probably benign Het
Hbs1l A G 10: 21,183,637 (GRCm39) E126G probably benign Het
Lrrc2 T A 9: 110,791,741 (GRCm39) probably null Het
Mrpl44 G A 1: 79,757,370 (GRCm39) V272I probably benign Het
Msh4 G A 3: 153,569,141 (GRCm39) L723F probably benign Het
Nemf T A 12: 69,388,384 (GRCm39) D329V probably damaging Het
Noxa1 A T 2: 24,981,806 (GRCm39) L99Q probably damaging Het
Nr6a1 A T 2: 38,775,218 (GRCm39) D44E probably benign Het
Obscn T C 11: 58,965,890 (GRCm39) D3131G probably damaging Het
Or10a5 T C 7: 106,635,401 (GRCm39) I13T probably benign Het
Or10c1 T G 17: 37,521,809 (GRCm39) I312L probably benign Het
Or52p2 A T 7: 102,237,654 (GRCm39) C99S probably damaging Het
Pkhd1l1 T A 15: 44,402,279 (GRCm39) probably null Het
Rbsn G A 6: 92,166,791 (GRCm39) Q618* probably null Het
Rccd1 A C 7: 79,968,799 (GRCm39) probably null Het
Socs5 T A 17: 87,441,201 (GRCm39) L47Q probably benign Het
Ttc16 T C 2: 32,652,880 (GRCm39) T593A probably benign Het
Ube4a T C 9: 44,851,271 (GRCm39) I748V probably damaging Het
Vipas39 T C 12: 87,288,105 (GRCm39) D435G probably benign Het
Vmn2r69 C T 7: 85,055,873 (GRCm39) G755D probably benign Het
Vsnl1 A G 12: 11,376,372 (GRCm39) F171S probably damaging Het
Wbp2nl G A 15: 82,198,275 (GRCm39) A271T probably benign Het
Other mutations in Scg2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01347:Scg2 APN 1 79,414,538 (GRCm39) missense probably benign 0.16
IGL02083:Scg2 APN 1 79,413,941 (GRCm39) missense probably benign 0.00
IGL02316:Scg2 APN 1 79,413,398 (GRCm39) missense probably damaging 1.00
IGL02338:Scg2 APN 1 79,414,210 (GRCm39) missense possibly damaging 0.93
R0281:Scg2 UTSW 1 79,413,229 (GRCm39) missense possibly damaging 0.95
R0384:Scg2 UTSW 1 79,413,266 (GRCm39) missense probably benign 0.42
R0501:Scg2 UTSW 1 79,413,320 (GRCm39) missense probably damaging 1.00
R1773:Scg2 UTSW 1 79,413,352 (GRCm39) missense probably benign 0.04
R2254:Scg2 UTSW 1 79,414,217 (GRCm39) missense probably damaging 1.00
R4074:Scg2 UTSW 1 79,414,574 (GRCm39) missense probably damaging 0.97
R4076:Scg2 UTSW 1 79,414,574 (GRCm39) missense probably damaging 0.97
R4097:Scg2 UTSW 1 79,413,538 (GRCm39) missense probably damaging 0.99
R4560:Scg2 UTSW 1 79,412,898 (GRCm39) missense probably damaging 1.00
R4621:Scg2 UTSW 1 79,414,381 (GRCm39) missense probably benign 0.08
R4876:Scg2 UTSW 1 79,413,636 (GRCm39) missense probably damaging 1.00
R4944:Scg2 UTSW 1 79,414,193 (GRCm39) nonsense probably null
R5829:Scg2 UTSW 1 79,414,637 (GRCm39) missense probably damaging 1.00
R6158:Scg2 UTSW 1 79,413,117 (GRCm39) missense probably damaging 1.00
R6248:Scg2 UTSW 1 79,414,023 (GRCm39) missense probably benign 0.29
R6365:Scg2 UTSW 1 79,413,017 (GRCm39) missense probably benign
R6459:Scg2 UTSW 1 79,414,007 (GRCm39) missense probably damaging 1.00
R6676:Scg2 UTSW 1 79,413,499 (GRCm39) missense possibly damaging 0.74
R6693:Scg2 UTSW 1 79,413,737 (GRCm39) missense probably benign 0.01
R7259:Scg2 UTSW 1 79,414,702 (GRCm39) missense probably benign
R7393:Scg2 UTSW 1 79,412,948 (GRCm39) missense probably damaging 1.00
R7578:Scg2 UTSW 1 79,414,612 (GRCm39) missense probably damaging 0.99
R7608:Scg2 UTSW 1 79,413,898 (GRCm39) missense probably benign 0.00
R8166:Scg2 UTSW 1 79,413,300 (GRCm39) missense possibly damaging 0.56
R8247:Scg2 UTSW 1 79,414,236 (GRCm39) missense possibly damaging 0.92
R8296:Scg2 UTSW 1 79,413,222 (GRCm39) missense probably benign 0.13
R8308:Scg2 UTSW 1 79,414,576 (GRCm39) missense probably benign 0.18
R8789:Scg2 UTSW 1 79,413,500 (GRCm39) missense probably benign 0.05
R9252:Scg2 UTSW 1 79,414,069 (GRCm39) missense probably damaging 0.98
R9286:Scg2 UTSW 1 79,413,653 (GRCm39) missense probably damaging 1.00
R9489:Scg2 UTSW 1 79,412,936 (GRCm39) missense probably damaging 1.00
R9605:Scg2 UTSW 1 79,412,936 (GRCm39) missense probably damaging 1.00
Z1176:Scg2 UTSW 1 79,414,506 (GRCm39) missense probably benign 0.17
Predicted Primers PCR Primer
(F):5'- AGGACCATAAGGGAGCCTCATCAG -3'
(R):5'- CAACTCTCAGAGGATGCCTCCAAAG -3'

Sequencing Primer
(F):5'- GAGCCTCATCAGAGCCTTGTC -3'
(R):5'- TCACCTACCTGAGAAGGTTAGTG -3'
Posted On 2013-11-08