Incidental Mutation 'R0909:Olfr551'
ID83427
Institutional Source Beutler Lab
Gene Symbol Olfr551
Ensembl Gene ENSMUSG00000073974
Gene Nameolfactory receptor 551
SynonymsMOR29-1, GA_x6K02T2PBJ9-5307445-5306498
MMRRC Submission 039067-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.086) question?
Stock #R0909 (G1)
Quality Score225
Status Not validated
Chromosome7
Chromosomal Location102583510-102591886 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 102588447 bp
ZygosityHeterozygous
Amino Acid Change Cysteine to Serine at position 99 (C99S)
Ref Sequence ENSEMBL: ENSMUSP00000150582 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098224] [ENSMUST00000213540]
Predicted Effect probably damaging
Transcript: ENSMUST00000098224
AA Change: C99S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000095827
Gene: ENSMUSG00000073974
AA Change: C99S

DomainStartEndE-ValueType
Pfam:7tm_4 33 310 2.8e-105 PFAM
Pfam:7TM_GPCR_Srsx 37 152 2e-9 PFAM
Pfam:7tm_1 43 293 1.9e-17 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213540
AA Change: C99S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.4%
  • 20x: 91.5%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1810055G02Rik T A 19: 3,715,788 M21K probably benign Het
Ap3s2 T C 7: 79,880,518 N183S probably benign Het
Cd109 A G 9: 78,636,473 I100V probably benign Het
Cep170b A G 12: 112,732,039 K77R probably null Het
Chmp5 C A 4: 40,960,968 N202K probably benign Het
Cnbd1 A T 4: 19,122,444 L15I probably benign Het
Ehmt2 T C 17: 34,906,504 V542A possibly damaging Het
Exosc9 A T 3: 36,554,704 I151F probably damaging Het
Eya2 A G 2: 165,754,493 N308S probably benign Het
Fbxw21 C A 9: 109,156,408 A101S possibly damaging Het
Frem3 A C 8: 80,663,406 N1762T probably benign Het
H2-DMb2 C A 17: 34,148,809 T68N probably benign Het
Hbs1l A G 10: 21,307,738 E126G probably benign Het
Lrrc2 T A 9: 110,962,673 probably null Het
Mrpl44 G A 1: 79,779,653 V272I probably benign Het
Msh4 G A 3: 153,863,504 L723F probably benign Het
Nemf T A 12: 69,341,610 D329V probably damaging Het
Noxa1 A T 2: 25,091,794 L99Q probably damaging Het
Nr6a1 A T 2: 38,885,206 D44E probably benign Het
Obscn T C 11: 59,075,064 D3131G probably damaging Het
Olfr713 T C 7: 107,036,194 I13T probably benign Het
Olfr95 T G 17: 37,210,918 I312L probably benign Het
Pkhd1l1 T A 15: 44,538,883 probably null Het
Rbsn G A 6: 92,189,810 Q618* probably null Het
Rccd1 A C 7: 80,319,051 probably null Het
Scg2 T A 1: 79,435,782 Q368L possibly damaging Het
Socs5 T A 17: 87,133,773 L47Q probably benign Het
Ttc16 T C 2: 32,762,868 T593A probably benign Het
Ube4a T C 9: 44,939,973 I748V probably damaging Het
Vipas39 T C 12: 87,241,331 D435G probably benign Het
Vmn2r69 C T 7: 85,406,665 G755D probably benign Het
Vsnl1 A G 12: 11,326,371 F171S probably damaging Het
Wbp2nl G A 15: 82,314,074 A271T probably benign Het
Other mutations in Olfr551
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01680:Olfr551 APN 7 102588229 nonsense probably null
IGL03034:Olfr551 APN 7 102587940 missense probably benign 0.42
IGL03076:Olfr551 APN 7 102588472 missense probably benign
R0564:Olfr551 UTSW 7 102588531 missense probably benign
R0890:Olfr551 UTSW 7 102588201 nonsense probably null
R1053:Olfr551 UTSW 7 102587959 nonsense probably null
R4708:Olfr551 UTSW 7 102587836 missense probably benign 0.00
R4932:Olfr551 UTSW 7 102588416 missense probably damaging 0.98
R6248:Olfr551 UTSW 7 102588030 missense probably benign 0.00
R6343:Olfr551 UTSW 7 102588546 missense probably damaging 0.98
R6389:Olfr551 UTSW 7 102588472 missense probably benign
R6455:Olfr551 UTSW 7 102588671 missense probably benign 0.00
R7305:Olfr551 UTSW 7 102587955 missense possibly damaging 0.94
Predicted Primers PCR Primer
(F):5'- GCAGCTCCTAACTTGCTCACAGAC -3'
(R):5'- TCGGCCTGATCATGCAACACAC -3'

Sequencing Primer
(F):5'- TAACTTGCTCACAGACTCTGAGG -3'
(R):5'- ATGCCCTAGCAGTTCTTGG -3'
Posted On2013-11-08