Incidental Mutation 'R0891:Calml3'
ID 83511
Institutional Source Beutler Lab
Gene Symbol Calml3
Ensembl Gene ENSMUSG00000063130
Gene Name calmodulin-like 3
Synonyms 2310068O22Rik
MMRRC Submission 039054-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.328) question?
Stock # R0891 (G1)
Quality Score 225
Status Validated
Chromosome 13
Chromosomal Location 3852896-3854316 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 3853926 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Serine at position 93 (F93S)
Ref Sequence ENSEMBL: ENSMUSP00000076880 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077698] [ENSMUST00000222976]
AlphaFold Q9D6P8
Predicted Effect probably damaging
Transcript: ENSMUST00000077698
AA Change: F93S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000076880
Gene: ENSMUSG00000063130
AA Change: F93S

DomainStartEndE-ValueType
EFh 12 40 1.28e-8 SMART
EFh 48 76 7.01e-6 SMART
EFh 85 113 7.34e-9 SMART
EFh 121 149 3.87e-8 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000222976
AA Change: F46S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Meta Mutation Damage Score 0.7194 question?
Coding Region Coverage
  • 1x: 99.7%
  • 3x: 98.9%
  • 10x: 96.7%
  • 20x: 92.2%
Validation Efficiency 100% (41/41)
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930522L14Rik A T 5: 109,884,156 (GRCm39) N567K possibly damaging Het
Afap1 G A 5: 36,119,196 (GRCm39) probably null Het
Angel2 G T 1: 190,677,270 (GRCm39) K517N possibly damaging Het
Ankrd36 A G 11: 5,637,316 (GRCm39) E1295G possibly damaging Het
Ankrd45 A G 1: 160,982,906 (GRCm39) N139S possibly damaging Het
Ano3 T C 2: 110,528,321 (GRCm39) T498A probably benign Het
Arhgap12 T C 18: 6,026,699 (GRCm39) T720A probably damaging Het
Brd10 G A 19: 29,695,053 (GRCm39) T1547I probably damaging Het
Brsk1 A G 7: 4,707,226 (GRCm39) S260G possibly damaging Het
Ccnf G T 17: 24,445,751 (GRCm39) H498Q possibly damaging Het
Col27a1 A C 4: 63,223,420 (GRCm39) probably null Het
Cpne5 A G 17: 29,421,893 (GRCm39) probably benign Het
Dcst1 G A 3: 89,260,584 (GRCm39) T560I probably benign Het
Fndc7 A G 3: 108,777,904 (GRCm39) Y351H possibly damaging Het
Gen1 A G 12: 11,298,355 (GRCm39) probably benign Het
Kcnh8 A T 17: 53,212,242 (GRCm39) D680V probably damaging Het
Kmt2d A G 15: 98,750,572 (GRCm39) probably benign Het
Lrrfip1 T A 1: 90,996,337 (GRCm39) I50N probably damaging Het
Mbip A T 12: 56,387,242 (GRCm39) D132E possibly damaging Het
Nipal3 A T 4: 135,195,898 (GRCm39) I235N possibly damaging Het
Nup93 T A 8: 95,007,891 (GRCm39) probably benign Het
Or6b13 A G 7: 139,782,372 (GRCm39) Y104H probably damaging Het
Or6z6 T A 7: 6,491,471 (GRCm39) Y134F probably damaging Het
Pgbd1 T C 13: 21,606,970 (GRCm39) Y408C probably damaging Het
Pigo G A 4: 43,020,519 (GRCm39) Q808* probably null Het
Pik3r1 A T 13: 101,837,974 (GRCm39) N299K probably benign Het
Pip5k1a A G 3: 94,972,831 (GRCm39) probably benign Het
Semp2l1 T A 1: 32,585,442 (GRCm39) H156L possibly damaging Het
Septin5 G C 16: 18,443,595 (GRCm39) T118R probably damaging Het
Smarcal1 T C 1: 72,638,015 (GRCm39) V483A probably damaging Het
Togaram1 A G 12: 65,029,421 (GRCm39) D948G probably benign Het
Vmn2r75 A T 7: 85,813,476 (GRCm39) V442E possibly damaging Het
Zfp57 A G 17: 37,317,068 (GRCm39) K46E probably damaging Het
Other mutations in Calml3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03252:Calml3 APN 13 3,853,759 (GRCm39) nonsense probably null
R1505:Calml3 UTSW 13 3,854,071 (GRCm39) missense probably benign
R4996:Calml3 UTSW 13 3,854,142 (GRCm39) missense probably damaging 0.97
R7788:Calml3 UTSW 13 3,854,121 (GRCm39) missense probably damaging 1.00
R8283:Calml3 UTSW 13 3,854,097 (GRCm39) missense probably damaging 1.00
Z1177:Calml3 UTSW 13 3,854,011 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGGCACAGCCTCATTTGGACAC -3'
(R):5'- AGCTGACTGAGGAGCAAATCGC -3'

Sequencing Primer
(F):5'- CATTTGGACACCAGCATGTGG -3'
(R):5'- CCGAGTTCAAAGAGGCTTTC -3'
Posted On 2013-11-08