Incidental Mutation 'R0892:Tatdn3'
ID 83524
Institutional Source Beutler Lab
Gene Symbol Tatdn3
Ensembl Gene ENSMUSG00000026632
Gene Name TatD DNase domain containing 3
Synonyms 1500010M24Rik
MMRRC Submission 039055-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0892 (G1)
Quality Score 216
Status Not validated
Chromosome 1
Chromosomal Location 190778023-190795129 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 190795002 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 18 (D18G)
Ref Sequence ENSEMBL: ENSMUSP00000106518 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027945] [ENSMUST00000076952] [ENSMUST00000078259] [ENSMUST00000085633] [ENSMUST00000110891] [ENSMUST00000110893] [ENSMUST00000139340]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000027945
AA Change: D18G

PolyPhen 2 Score 0.225 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000027945
Gene: ENSMUSG00000026632
AA Change: D18G

DomainStartEndE-ValueType
Pfam:TatD_DNase 6 263 5e-57 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000076952
SMART Domains Protein: ENSMUSP00000076220
Gene: ENSMUSG00000062510

DomainStartEndE-ValueType
low complexity region 18 32 N/A INTRINSIC
Pfam:Mis14 67 170 1.6e-26 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000078259
SMART Domains Protein: ENSMUSP00000077380
Gene: ENSMUSG00000062510

DomainStartEndE-ValueType
low complexity region 18 32 N/A INTRINSIC
Pfam:Mis14 82 197 2.9e-26 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000085633
AA Change: D18G

PolyPhen 2 Score 0.225 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000082773
Gene: ENSMUSG00000026632
AA Change: D18G

DomainStartEndE-ValueType
Pfam:TatD_DNase 6 170 1.1e-32 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000110891
AA Change: D18G

PolyPhen 2 Score 0.080 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000106516
Gene: ENSMUSG00000026632
AA Change: D18G

DomainStartEndE-ValueType
Pfam:TatD_DNase 6 231 2.3e-46 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000110893
AA Change: D18G

PolyPhen 2 Score 0.225 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000106518
Gene: ENSMUSG00000026632
AA Change: D18G

DomainStartEndE-ValueType
Pfam:TatD_DNase 6 264 1.8e-57 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000124497
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156527
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143876
Predicted Effect noncoding transcript
Transcript: ENSMUST00000153757
Predicted Effect probably benign
Transcript: ENSMUST00000139340
SMART Domains Protein: ENSMUSP00000115289
Gene: ENSMUSG00000062510

DomainStartEndE-ValueType
low complexity region 18 32 N/A INTRINSIC
Pfam:Mis14 67 171 7e-27 PFAM
Coding Region Coverage
  • 1x: 99.5%
  • 3x: 98.9%
  • 10x: 97.5%
  • 20x: 95.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 T A 11: 9,248,305 (GRCm39) V2684E probably benign Het
Ankub1 T C 3: 57,597,800 (GRCm39) R57G probably benign Het
Bcr C T 10: 74,960,895 (GRCm39) A442V probably benign Het
Cd46 T C 1: 194,764,920 (GRCm39) T226A possibly damaging Het
Dmkn C T 7: 30,466,829 (GRCm39) R114C probably damaging Het
Ell2 A T 13: 75,911,758 (GRCm39) N348I probably damaging Het
Epg5 T A 18: 78,011,843 (GRCm39) I830N possibly damaging Het
Gm15737 C T 6: 92,856,721 (GRCm39) probably benign Het
Gpa33 A G 1: 165,985,211 (GRCm39) N182S probably damaging Het
Gpr37 A T 6: 25,688,206 (GRCm39) I297N probably damaging Het
Hpse2 T C 19: 43,376,585 (GRCm39) K56E probably benign Het
Lamc1 G A 1: 153,208,000 (GRCm39) H96Y possibly damaging Het
Mapre2 A G 18: 23,991,200 (GRCm39) N189S probably benign Het
Msmo1 T A 8: 65,175,587 (GRCm39) I148F possibly damaging Het
Myh6 T C 14: 55,184,511 (GRCm39) T1607A probably benign Het
Oog2 A T 4: 143,923,069 (GRCm39) T445S probably benign Het
Or5b122 T A 19: 13,562,881 (GRCm39) V28D probably damaging Het
Plag1 G A 4: 3,904,532 (GRCm39) Q220* probably null Het
Pom121l2 A G 13: 22,166,644 (GRCm39) E305G possibly damaging Het
Prorp A G 12: 55,429,033 (GRCm39) probably null Het
Sbsn A T 7: 30,454,244 (GRCm39) Q50L possibly damaging Het
Slc25a42 A G 8: 70,644,597 (GRCm39) L34P probably damaging Het
Sptbn1 C A 11: 30,092,201 (GRCm39) R521S probably damaging Het
St14 A T 9: 31,011,724 (GRCm39) V394E probably benign Het
Trappc8 A G 18: 20,964,665 (GRCm39) probably null Het
Other mutations in Tatdn3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01383:Tatdn3 APN 1 190,787,578 (GRCm39) splice site probably benign
IGL02819:Tatdn3 APN 1 190,787,541 (GRCm39) missense probably benign 0.04
IGL02898:Tatdn3 APN 1 190,778,507 (GRCm39) makesense probably null
R0718:Tatdn3 UTSW 1 190,785,046 (GRCm39) splice site probably benign
R1635:Tatdn3 UTSW 1 190,792,373 (GRCm39) missense probably benign
R2018:Tatdn3 UTSW 1 190,781,477 (GRCm39) critical splice donor site probably null
R2088:Tatdn3 UTSW 1 190,785,073 (GRCm39) missense possibly damaging 0.59
R2243:Tatdn3 UTSW 1 190,785,097 (GRCm39) missense probably damaging 1.00
R3933:Tatdn3 UTSW 1 190,778,521 (GRCm39) splice site probably null
R4676:Tatdn3 UTSW 1 190,781,531 (GRCm39) missense probably damaging 1.00
R5047:Tatdn3 UTSW 1 190,778,475 (GRCm39) missense probably damaging 1.00
R5923:Tatdn3 UTSW 1 190,781,507 (GRCm39) missense probably damaging 1.00
R6044:Tatdn3 UTSW 1 190,788,558 (GRCm39) critical splice donor site probably null
R6066:Tatdn3 UTSW 1 190,778,465 (GRCm39) missense probably benign 0.24
R7770:Tatdn3 UTSW 1 190,791,053 (GRCm39) missense probably benign 0.05
R8331:Tatdn3 UTSW 1 190,778,408 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCAGCACACCTCAAGAGTGGTAGG -3'
(R):5'- TTTCAGAGACAGCCGCCATCTTCC -3'

Sequencing Primer
(F):5'- GTTGAGACGACAAACTAAAGCTTC -3'
(R):5'- GAAGGATGCTTCCCTCCCTG -3'
Posted On 2013-11-08