Incidental Mutation 'R0892:Prorp'
ID 83542
Institutional Source Beutler Lab
Gene Symbol Prorp
Ensembl Gene ENSMUSG00000021023
Gene Name protein only RNase P catalytic subunit
Synonyms Mrpp3, 1110008L16Rik
MMRRC Submission 039055-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.513) question?
Stock # R0892 (G1)
Quality Score 225
Status Not validated
Chromosome 12
Chromosomal Location 55349422-55429276 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to G at 55429033 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000139123 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021411] [ENSMUST00000021411] [ENSMUST00000163070] [ENSMUST00000183475] [ENSMUST00000183475] [ENSMUST00000183654] [ENSMUST00000183654] [ENSMUST00000184766] [ENSMUST00000184766] [ENSMUST00000184980] [ENSMUST00000184980]
AlphaFold Q8JZY4
Predicted Effect probably null
Transcript: ENSMUST00000021411
SMART Domains Protein: ENSMUSP00000021411
Gene: ENSMUSG00000021023

DomainStartEndE-ValueType
Pfam:PRORP 339 575 4.8e-106 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000021411
SMART Domains Protein: ENSMUSP00000021411
Gene: ENSMUSG00000021023

DomainStartEndE-ValueType
Pfam:PRORP 339 575 4.8e-106 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000163070
SMART Domains Protein: ENSMUSP00000124781
Gene: ENSMUSG00000021024

DomainStartEndE-ValueType
Pfam:Proteasome 13 201 1.5e-56 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000183475
SMART Domains Protein: ENSMUSP00000139252
Gene: ENSMUSG00000021023

DomainStartEndE-ValueType
low complexity region 410 424 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000183475
SMART Domains Protein: ENSMUSP00000139252
Gene: ENSMUSG00000021023

DomainStartEndE-ValueType
low complexity region 410 424 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000183654
SMART Domains Protein: ENSMUSP00000138821
Gene: ENSMUSG00000021023

DomainStartEndE-ValueType
Pfam:RNase_Zc3h12a 33 185 8e-7 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000183654
SMART Domains Protein: ENSMUSP00000138821
Gene: ENSMUSG00000021023

DomainStartEndE-ValueType
Pfam:RNase_Zc3h12a 33 185 8e-7 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000184766
SMART Domains Protein: ENSMUSP00000139204
Gene: ENSMUSG00000021023

DomainStartEndE-ValueType
PDB:4G26|A 153 581 1e-9 PDB
Predicted Effect probably null
Transcript: ENSMUST00000184766
SMART Domains Protein: ENSMUSP00000139204
Gene: ENSMUSG00000021023

DomainStartEndE-ValueType
PDB:4G26|A 153 581 1e-9 PDB
Predicted Effect probably null
Transcript: ENSMUST00000184980
SMART Domains Protein: ENSMUSP00000139123
Gene: ENSMUSG00000021023

DomainStartEndE-ValueType
low complexity region 113 127 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000184980
SMART Domains Protein: ENSMUSP00000139123
Gene: ENSMUSG00000021023

DomainStartEndE-ValueType
low complexity region 113 127 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.5%
  • 3x: 98.9%
  • 10x: 97.5%
  • 20x: 95.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 T A 11: 9,248,305 (GRCm39) V2684E probably benign Het
Ankub1 T C 3: 57,597,800 (GRCm39) R57G probably benign Het
Bcr C T 10: 74,960,895 (GRCm39) A442V probably benign Het
Cd46 T C 1: 194,764,920 (GRCm39) T226A possibly damaging Het
Dmkn C T 7: 30,466,829 (GRCm39) R114C probably damaging Het
Ell2 A T 13: 75,911,758 (GRCm39) N348I probably damaging Het
Epg5 T A 18: 78,011,843 (GRCm39) I830N possibly damaging Het
Gm15737 C T 6: 92,856,721 (GRCm39) probably benign Het
Gpa33 A G 1: 165,985,211 (GRCm39) N182S probably damaging Het
Gpr37 A T 6: 25,688,206 (GRCm39) I297N probably damaging Het
Hpse2 T C 19: 43,376,585 (GRCm39) K56E probably benign Het
Lamc1 G A 1: 153,208,000 (GRCm39) H96Y possibly damaging Het
Mapre2 A G 18: 23,991,200 (GRCm39) N189S probably benign Het
Msmo1 T A 8: 65,175,587 (GRCm39) I148F possibly damaging Het
Myh6 T C 14: 55,184,511 (GRCm39) T1607A probably benign Het
Oog2 A T 4: 143,923,069 (GRCm39) T445S probably benign Het
Or5b122 T A 19: 13,562,881 (GRCm39) V28D probably damaging Het
Plag1 G A 4: 3,904,532 (GRCm39) Q220* probably null Het
Pom121l2 A G 13: 22,166,644 (GRCm39) E305G possibly damaging Het
Sbsn A T 7: 30,454,244 (GRCm39) Q50L possibly damaging Het
Slc25a42 A G 8: 70,644,597 (GRCm39) L34P probably damaging Het
Sptbn1 C A 11: 30,092,201 (GRCm39) R521S probably damaging Het
St14 A T 9: 31,011,724 (GRCm39) V394E probably benign Het
Tatdn3 T C 1: 190,795,002 (GRCm39) D18G probably benign Het
Trappc8 A G 18: 20,964,665 (GRCm39) probably null Het
Other mutations in Prorp
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01701:Prorp APN 12 55,355,660 (GRCm39) splice site probably benign
IGL01932:Prorp APN 12 55,350,910 (GRCm39) missense probably benign
IGL03030:Prorp APN 12 55,351,429 (GRCm39) missense probably damaging 1.00
R0102:Prorp UTSW 12 55,429,082 (GRCm39) missense probably benign 0.37
R1479:Prorp UTSW 12 55,426,172 (GRCm39) missense probably damaging 1.00
R1510:Prorp UTSW 12 55,350,997 (GRCm39) missense probably benign 0.21
R1845:Prorp UTSW 12 55,351,117 (GRCm39) missense possibly damaging 0.58
R1992:Prorp UTSW 12 55,384,991 (GRCm39) missense probably damaging 1.00
R2307:Prorp UTSW 12 55,351,101 (GRCm39) missense probably damaging 1.00
R4080:Prorp UTSW 12 55,351,398 (GRCm39) missense possibly damaging 0.88
R4081:Prorp UTSW 12 55,351,398 (GRCm39) missense possibly damaging 0.88
R4082:Prorp UTSW 12 55,351,398 (GRCm39) missense possibly damaging 0.88
R5205:Prorp UTSW 12 55,351,226 (GRCm39) nonsense probably null
R5590:Prorp UTSW 12 55,351,257 (GRCm39) missense possibly damaging 0.89
R5940:Prorp UTSW 12 55,351,659 (GRCm39) missense probably damaging 1.00
R5988:Prorp UTSW 12 55,424,002 (GRCm39) missense probably damaging 1.00
R6147:Prorp UTSW 12 55,426,093 (GRCm39) missense probably damaging 0.99
R7208:Prorp UTSW 12 55,355,430 (GRCm39) splice site probably null
R7220:Prorp UTSW 12 55,351,200 (GRCm39) missense possibly damaging 0.79
R7304:Prorp UTSW 12 55,351,429 (GRCm39) missense probably damaging 1.00
R7316:Prorp UTSW 12 55,351,429 (GRCm39) missense probably damaging 1.00
R7502:Prorp UTSW 12 55,351,206 (GRCm39) missense probably damaging 1.00
R7908:Prorp UTSW 12 55,426,250 (GRCm39) missense possibly damaging 0.56
R7967:Prorp UTSW 12 55,350,979 (GRCm39) missense probably benign
R9030:Prorp UTSW 12 55,426,192 (GRCm39) missense probably damaging 1.00
R9125:Prorp UTSW 12 55,355,611 (GRCm39) missense possibly damaging 0.77
R9135:Prorp UTSW 12 55,426,189 (GRCm39) missense probably damaging 1.00
R9136:Prorp UTSW 12 55,350,727 (GRCm39) missense probably benign
R9321:Prorp UTSW 12 55,351,434 (GRCm39) missense possibly damaging 0.94
R9456:Prorp UTSW 12 55,385,015 (GRCm39) missense probably damaging 1.00
R9621:Prorp UTSW 12 55,429,042 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- AGCACAGCGAAACAATCCTGTAACTTAT -3'
(R):5'- CCAGGAGGCCATGCGACTCA -3'

Sequencing Primer
(F):5'- tgtggaaatggtaggaaaggg -3'
(R):5'- ATGCGACTCAGCAGGGG -3'
Posted On 2013-11-08