|Institutional Source||Beutler Lab|
|Gene Name||lysophosphatidic acid receptor 3|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R0893 (G1)|
|Chromosomal Location||146220963-146286186 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||C to T at 146240593 bp|
|Amino Acid Change||Arginine to Cysteine at position 9 (R9C)|
|Ref Sequence||ENSEMBL: ENSMUSP00000037712 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000039164]|
|Predicted Effect||possibly damaging
AA Change: R9C
PolyPhen 2 Score 0.822 (Sensitivity: 0.84; Specificity: 0.93)
AA Change: R9C
|Meta Mutation Damage Score||0.06|
|Coding Region Coverage||
|Validation Efficiency||99% (77/78)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null females produce smaller litter sizes and exhibit delayed implantation and altered embryo spacing that leads to delayed development of embryos and hypertrophic placentas that were shared by multiple embryos. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Lpar3||
(F):5'- CAGACTGGGAATCGTAAGACAGCAC -3'
(R):5'- ATCCGCAGCAGCTAAGTTAGCC -3'
(F):5'- TTCAGCCTACCTGGGGAAATG -3'
(R):5'- GCAGCTAAGTTAGCCAGCAG -3'