Incidental Mutation 'R0893:Rgs3'
ID 83576
Institutional Source Beutler Lab
Gene Symbol Rgs3
Ensembl Gene ENSMUSG00000059810
Gene Name regulator of G-protein signaling 3
Synonyms 4930506N09Rik, C2PA-RGS3, C2pa, PDZ-RGS3, RGS3S
MMRRC Submission 039056-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.081) question?
Stock # R0893 (G1)
Quality Score 225
Status Validated
Chromosome 4
Chromosomal Location 62478079-62621256 bp(+) (GRCm39)
Type of Mutation splice site (15 bp from exon)
DNA Base Change (assembly) G to A at 62523798 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000095639 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000065870] [ENSMUST00000098031] [ENSMUST00000098031]
AlphaFold Q9DC04
Predicted Effect probably null
Transcript: ENSMUST00000065870
SMART Domains Protein: ENSMUSP00000065447
Gene: ENSMUSG00000059810

DomainStartEndE-ValueType
C2 47 150 7.98e-15 SMART
PDZ 203 272 8.09e-10 SMART
low complexity region 465 475 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000098031
SMART Domains Protein: ENSMUSP00000095639
Gene: ENSMUSG00000059810

DomainStartEndE-ValueType
C2 39 142 7.98e-15 SMART
PDZ 195 264 8.09e-10 SMART
low complexity region 457 467 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000098031
SMART Domains Protein: ENSMUSP00000095639
Gene: ENSMUSG00000059810

DomainStartEndE-ValueType
C2 39 142 7.98e-15 SMART
PDZ 195 264 8.09e-10 SMART
low complexity region 457 467 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000146083
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.9%
  • 10x: 97.4%
  • 20x: 95.1%
Validation Efficiency 99% (77/78)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTPase-activating protein that inhibits G-protein-mediated signal transduction. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. Long isoforms are largely cytosolic and plasma membrane-associated with a function in Wnt signaling and in the epithelial mesenchymal transition, while shorter N-terminally-truncated isoforms can be nuclear. [provided by RefSeq, Jan 2013]
PHENOTYPE: Mice homozygous for a targeted allele exhibit impaired T cell migration in model of Th2-mediated airway inflammation. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 77 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik T A 12: 71,266,082 (GRCm39) probably benign Het
Adnp A T 2: 168,025,647 (GRCm39) F549L possibly damaging Het
Agl A G 3: 116,546,935 (GRCm39) I1305T probably benign Het
Aldh8a1 T A 10: 21,267,593 (GRCm39) M326K probably benign Het
Amdhd1 A T 10: 93,363,513 (GRCm39) M295K probably damaging Het
Arhgef4 T A 1: 34,846,191 (GRCm39) C324S probably damaging Het
Car8 A T 4: 8,238,119 (GRCm39) probably null Het
Cc2d1a T C 8: 84,867,468 (GRCm39) probably benign Het
Cd81 G A 7: 142,616,242 (GRCm39) V27M possibly damaging Het
Ces1b A T 8: 93,806,056 (GRCm39) S62T probably benign Het
Cfb A G 17: 35,077,031 (GRCm39) S30P probably damaging Het
Cmtm3 A G 8: 105,070,543 (GRCm39) M101V possibly damaging Het
Cul7 T A 17: 46,974,116 (GRCm39) L1467H probably damaging Het
Ddb1 C T 19: 10,590,280 (GRCm39) S269L probably benign Het
Ddx25 G A 9: 35,465,686 (GRCm39) Q143* probably null Het
Dis3l2 T A 1: 86,971,928 (GRCm39) probably null Het
Dlgap4 G T 2: 156,587,898 (GRCm39) E598* probably null Het
Dus1l C T 11: 120,680,262 (GRCm39) G471D possibly damaging Het
Elp4 C A 2: 105,727,290 (GRCm39) probably benign Het
Eya3 A G 4: 132,417,097 (GRCm39) N194S probably benign Het
Golgb1 G T 16: 36,732,639 (GRCm39) V629L possibly damaging Het
Hars2 G A 18: 36,920,648 (GRCm39) A164T possibly damaging Het
Hexb T A 13: 97,322,135 (GRCm39) I217L probably benign Het
Hgh1 A G 15: 76,253,848 (GRCm39) probably null Het
Hsd3b3 A T 3: 98,649,757 (GRCm39) probably null Het
Ighg2c T A 12: 113,251,053 (GRCm39) N321Y unknown Het
Il5 A G 11: 53,611,763 (GRCm39) T34A probably benign Het
Jph1 C A 1: 17,074,507 (GRCm39) E504* probably null Het
Kif2b G T 11: 91,466,420 (GRCm39) T621K probably benign Het
Kmt2c A T 5: 25,556,268 (GRCm39) probably benign Het
Leprotl1 A G 8: 34,606,006 (GRCm39) probably null Het
Lpar3 C T 3: 145,946,348 (GRCm39) R9C possibly damaging Het
Map1a A G 2: 121,131,014 (GRCm39) E372G probably damaging Het
Map2 C A 1: 66,419,927 (GRCm39) T86K probably damaging Het
Map7 A G 10: 20,149,629 (GRCm39) probably null Het
Mdn1 T C 4: 32,701,713 (GRCm39) V1482A probably benign Het
Mks1 G A 11: 87,747,777 (GRCm39) probably benign Het
Morf4l1 T G 9: 89,984,403 (GRCm39) K102N probably damaging Het
Mroh1 T A 15: 76,293,138 (GRCm39) V304D possibly damaging Het
Mtg1 G A 7: 139,729,665 (GRCm39) V252M probably damaging Het
Myh13 A T 11: 67,225,427 (GRCm39) D264V probably damaging Het
Myh2 A G 11: 67,077,334 (GRCm39) Y823C possibly damaging Het
Myoz1 A T 14: 20,701,252 (GRCm39) S112R probably benign Het
Ncapd2 A G 6: 125,150,445 (GRCm39) V860A probably benign Het
Nfix G A 8: 85,453,155 (GRCm39) R300C probably damaging Het
Npffr1 T C 10: 61,450,010 (GRCm39) F95L possibly damaging Het
Or51f1e G T 7: 102,747,641 (GRCm39) R231L probably benign Het
Or8b9 T C 9: 37,766,492 (GRCm39) I126T probably damaging Het
Orc4 A C 2: 48,822,622 (GRCm39) probably benign Het
P3h3 A C 6: 124,822,476 (GRCm39) I565R probably damaging Het
Pak4 T C 7: 28,259,202 (GRCm39) D552G probably benign Het
Pcdhb4 G T 18: 37,442,423 (GRCm39) probably null Het
Pdcd4 G T 19: 53,917,525 (GRCm39) R454L probably damaging Het
Phf8-ps T C 17: 33,284,263 (GRCm39) I846M probably benign Het
Pkd1l2 A G 8: 117,771,231 (GRCm39) I1116T probably damaging Het
Plcb2 A G 2: 118,555,586 (GRCm39) probably benign Het
Pmpca T C 2: 26,283,230 (GRCm39) probably benign Het
Pnpla7 T A 2: 24,887,252 (GRCm39) I32N probably damaging Het
Prpf8 A G 11: 75,384,775 (GRCm39) K718E probably damaging Het
Racgap1 C T 15: 99,524,411 (GRCm39) A359T probably benign Het
Rhpn1 A G 15: 75,583,503 (GRCm39) E356G probably damaging Het
Rps6ka5 T C 12: 100,540,697 (GRCm39) H488R possibly damaging Het
Scn11a A G 9: 119,632,396 (GRCm39) probably null Het
Sema4f A T 6: 82,912,948 (GRCm39) probably benign Het
Serpina1f A G 12: 103,660,094 (GRCm39) S63P probably damaging Het
Slc9a3 T C 13: 74,307,365 (GRCm39) W386R probably damaging Het
Slc9b1 A C 3: 135,100,651 (GRCm39) L465F probably benign Het
Smc5 A G 19: 23,241,017 (GRCm39) V165A possibly damaging Het
Tex10 C T 4: 48,456,800 (GRCm39) R637Q probably benign Het
Tinagl1 G T 4: 130,067,816 (GRCm39) D59E probably damaging Het
Tns3 A G 11: 8,443,302 (GRCm39) Y354H probably damaging Het
Trappc9 C T 15: 72,461,956 (GRCm39) G1103D probably damaging Het
Unc79 A T 12: 102,957,687 (GRCm39) D34V probably damaging Het
Unc80 T C 1: 66,560,645 (GRCm39) L791P probably damaging Het
Unc93a2 A G 17: 7,641,926 (GRCm39) L174P probably damaging Het
Xpo7 G T 14: 70,903,537 (GRCm39) probably benign Het
Zbtb1 T A 12: 76,432,113 (GRCm39) I33N probably damaging Het
Other mutations in Rgs3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00510:Rgs3 APN 4 62,619,417 (GRCm39) missense possibly damaging 0.87
IGL00918:Rgs3 APN 4 62,619,304 (GRCm39) missense probably damaging 1.00
IGL01594:Rgs3 APN 4 62,537,981 (GRCm39) missense probably damaging 0.99
IGL01761:Rgs3 APN 4 62,570,946 (GRCm39) splice site probably benign
IGL02995:Rgs3 APN 4 62,544,084 (GRCm39) missense possibly damaging 0.95
IGL03365:Rgs3 APN 4 62,607,912 (GRCm39) missense probably benign
R0098:Rgs3 UTSW 4 62,544,143 (GRCm39) missense probably damaging 1.00
R0098:Rgs3 UTSW 4 62,544,143 (GRCm39) missense probably damaging 1.00
R0158:Rgs3 UTSW 4 62,542,121 (GRCm39) missense probably damaging 1.00
R0609:Rgs3 UTSW 4 62,544,173 (GRCm39) missense probably damaging 1.00
R0633:Rgs3 UTSW 4 62,544,143 (GRCm39) missense probably damaging 1.00
R0637:Rgs3 UTSW 4 62,564,910 (GRCm39) splice site probably benign
R1612:Rgs3 UTSW 4 62,544,172 (GRCm39) missense probably damaging 0.99
R1929:Rgs3 UTSW 4 62,620,384 (GRCm39) missense probably damaging 1.00
R2202:Rgs3 UTSW 4 62,608,741 (GRCm39) missense probably damaging 1.00
R2239:Rgs3 UTSW 4 62,544,124 (GRCm39) missense probably benign 0.30
R2380:Rgs3 UTSW 4 62,544,124 (GRCm39) missense probably benign 0.30
R2974:Rgs3 UTSW 4 62,558,957 (GRCm39) missense probably damaging 1.00
R4871:Rgs3 UTSW 4 62,549,532 (GRCm39) missense probably benign 0.01
R5229:Rgs3 UTSW 4 62,620,424 (GRCm39) missense probably damaging 1.00
R5372:Rgs3 UTSW 4 62,570,934 (GRCm39) intron probably benign
R5597:Rgs3 UTSW 4 62,542,082 (GRCm39) missense probably damaging 1.00
R6006:Rgs3 UTSW 4 62,542,143 (GRCm39) missense probably damaging 1.00
R6056:Rgs3 UTSW 4 62,544,143 (GRCm39) missense probably damaging 0.96
R6732:Rgs3 UTSW 4 62,521,180 (GRCm39) missense probably benign 0.00
R6962:Rgs3 UTSW 4 62,618,952 (GRCm39) intron probably benign
R7141:Rgs3 UTSW 4 62,608,724 (GRCm39) missense probably damaging 1.00
R7156:Rgs3 UTSW 4 62,535,363 (GRCm39) missense probably damaging 0.99
R7193:Rgs3 UTSW 4 62,533,573 (GRCm39) missense probably damaging 0.99
R7459:Rgs3 UTSW 4 62,543,391 (GRCm39) missense probably benign 0.01
R7660:Rgs3 UTSW 4 62,619,349 (GRCm39) missense possibly damaging 0.94
R7697:Rgs3 UTSW 4 62,575,379 (GRCm39) missense probably benign 0.00
R8025:Rgs3 UTSW 4 62,608,831 (GRCm39) missense probably damaging 0.97
R8059:Rgs3 UTSW 4 62,521,214 (GRCm39) splice site probably benign
R8242:Rgs3 UTSW 4 62,538,022 (GRCm39) missense probably benign
R8413:Rgs3 UTSW 4 62,544,254 (GRCm39) missense possibly damaging 0.54
R8489:Rgs3 UTSW 4 62,544,733 (GRCm39) missense probably damaging 1.00
R8501:Rgs3 UTSW 4 62,521,193 (GRCm39) missense possibly damaging 0.85
R8880:Rgs3 UTSW 4 62,543,373 (GRCm39) missense probably damaging 1.00
R9065:Rgs3 UTSW 4 62,620,465 (GRCm39) missense probably benign 0.05
R9094:Rgs3 UTSW 4 62,500,240 (GRCm39) missense probably damaging 1.00
R9318:Rgs3 UTSW 4 62,559,019 (GRCm39) missense probably benign 0.05
R9483:Rgs3 UTSW 4 62,575,354 (GRCm39) nonsense probably null
R9498:Rgs3 UTSW 4 62,575,412 (GRCm39) missense probably damaging 1.00
R9522:Rgs3 UTSW 4 62,523,729 (GRCm39) missense probably benign 0.12
Z1177:Rgs3 UTSW 4 62,549,451 (GRCm39) missense possibly damaging 0.67
Predicted Primers PCR Primer
(F):5'- GAATCCTACTGCCCACAGCTATGTC -3'
(R):5'- TGTTTCAGTCACCAGCACAGTCAC -3'

Sequencing Primer
(F):5'- CCACAGCTATGTCTTCTATTTGAG -3'
(R):5'- CTAAGGACTCTAGCTCTTGACCAAAG -3'
Posted On 2013-11-08