Mutagenetix > Incidental Mutation

Incidental Mutation 'R0021:Zfp790'

8378

Institutional Source

Beutler Lab

Gene Symbol

Zfp790

Ensembl Gene

ENSMUSG00000011427

Gene Name

zinc finger protein 790

Synonyms

6330581L23Rik

MMRRC Submission

038316-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.053) question?

Stock #

R0021 (G1)

Quality Score

Status

Validated

Chromosome

Chromosomal Location

29515539-29530430 bp(+) (GRCm39)

Type of Mutation

unclassified

DNA Base Change (assembly)

G to A at 29525113 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000146955 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000032796] [ENSMUST00000178162] [ENSMUST00000207328]

AlphaFold

Q80ZX2

Predicted Effect

probably benign
Transcript: ENSMUST00000032796

SMART Domains

Protein: ENSMUSP00000032796
Gene: ENSMUSG00000011427

Domain	Start	End	E-Value	Type
KRAB	5	65	3e-27	SMART
ZnF_C2H2	224	246	2.95e-3	SMART
ZnF_C2H2	252	274	2.53e-2	SMART
ZnF_C2H2	280	302	5.5e-3	SMART
ZnF_C2H2	308	330	2.75e-3	SMART
ZnF_C2H2	336	358	2.12e-4	SMART
ZnF_C2H2	364	386	1.03e-2	SMART
Pfam:zf-C2H2_6	391	403	2.4e-1	PFAM
ZnF_C2H2	448	470	9.56e1	SMART
ZnF_C2H2	476	498	7.26e-3	SMART
ZnF_C2H2	504	526	2.57e-3	SMART
ZnF_C2H2	532	554	6.42e-4	SMART
ZnF_C2H2	640	662	1.12e-3	SMART
ZnF_C2H2	668	690	2.12e-4	SMART
ZnF_C2H2	696	718	1.98e-4	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000178162

SMART Domains

Protein: ENSMUSP00000136932
Gene: ENSMUSG00000011427

Domain	Start	End	E-Value	Type
KRAB	5	65	3e-27	SMART
ZnF_C2H2	224	246	2.95e-3	SMART
ZnF_C2H2	252	274	2.53e-2	SMART
ZnF_C2H2	280	302	5.5e-3	SMART
ZnF_C2H2	308	330	2.75e-3	SMART
ZnF_C2H2	336	358	2.12e-4	SMART
ZnF_C2H2	364	386	1.03e-2	SMART
ZnF_C2H2	448	470	9.56e1	SMART
ZnF_C2H2	476	498	7.26e-3	SMART
ZnF_C2H2	504	526	2.57e-3	SMART
ZnF_C2H2	532	554	6.42e-4	SMART
ZnF_C2H2	640	662	1.12e-3	SMART
ZnF_C2H2	668	690	2.12e-4	SMART
ZnF_C2H2	696	718	1.98e-4	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000207328

Coding Region Coverage

1x: 84.2%
3x: 78.9%
10x: 65.7%
20x: 50.3%

Validation Efficiency

96% (92/96)

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2310016G11Rik	A	G	7: 44,326,620 (GRCm39)		noncoding transcript	Het
Abcc5	T	A	16: 20,197,411 (GRCm39)	K647*	probably null	Het
Aplp1	A	G	7: 30,135,241 (GRCm39)		probably benign	Het
Baiap3	T	C	17: 25,462,643 (GRCm39)	E1105G	probably damaging	Het
Brinp3	T	G	1: 146,777,189 (GRCm39)	S545R	probably benign	Het
Btnl1	A	G	17: 34,598,468 (GRCm39)	E28G	probably benign	Het
Ccr6	G	A	17: 8,475,598 (GRCm39)	V268M	possibly damaging	Het
Clstn1	G	A	4: 149,719,253 (GRCm39)	V361M	probably damaging	Het
Col1a2	G	A	6: 4,518,822 (GRCm39)		probably benign	Het
D630045J12Rik	G	A	6: 38,160,902 (GRCm39)	Q1081*	probably null	Het
Dhx15	T	C	5: 52,314,830 (GRCm39)	T626A	probably damaging	Het
Dhx36	T	C	3: 62,385,016 (GRCm39)	I699V	possibly damaging	Het
Dnah9	A	G	11: 65,860,805 (GRCm39)	I2855T	probably benign	Het
Duxf4	C	A	10: 58,071,385 (GRCm39)	E276D	probably benign	Het
Fsip2	T	A	2: 82,830,201 (GRCm39)		probably benign	Het
Galnt11	A	T	5: 25,453,855 (GRCm39)	D27V	probably damaging	Het
Gm5134	T	A	10: 75,829,718 (GRCm39)	C335S	probably damaging	Het
Hdhd2	A	T	18: 77,058,311 (GRCm39)	K227N	probably damaging	Het
Itgb4	A	T	11: 115,870,453 (GRCm39)	D94V	possibly damaging	Het
Krtcap3	A	G	5: 31,410,303 (GRCm39)	H227R	probably benign	Het
Macf1	T	C	4: 123,369,370 (GRCm39)	H232R	probably damaging	Het
Map2k4	A	G	11: 65,603,110 (GRCm39)	I174T	probably damaging	Het
Mcc	C	G	18: 44,652,583 (GRCm39)		probably benign	Het
Mcm9	G	A	10: 53,413,997 (GRCm39)	T1099I	possibly damaging	Het
Nkapd1	A	C	9: 50,521,725 (GRCm39)	D65E	probably damaging	Het
Nqo2	T	C	13: 34,165,490 (GRCm39)	I129T	probably benign	Het
Pdgfrb	T	A	18: 61,197,998 (GRCm39)		probably benign	Het
Phf7	C	T	14: 30,960,443 (GRCm39)		probably benign	Het
Plac8	T	A	5: 100,704,434 (GRCm39)	T88S	probably benign	Het
Prss52	T	G	14: 64,341,857 (GRCm39)	V16G	probably benign	Het
Psmb9	G	A	17: 34,403,277 (GRCm39)	A80V	probably benign	Het
Ptprk	T	A	10: 28,468,891 (GRCm39)	V1425E	probably damaging	Het
Scart2	G	A	7: 139,876,310 (GRCm39)	R594H	probably benign	Het
Scn2a	T	C	2: 65,500,859 (GRCm39)	V7A	possibly damaging	Het
Serpini1	T	C	3: 75,526,620 (GRCm39)	Y291H	probably damaging	Het
Setd6	A	G	8: 96,443,293 (GRCm39)	K19E	probably damaging	Het
Siah2	T	C	3: 58,583,713 (GRCm39)	H191R	probably benign	Het
Slc27a2	T	C	2: 126,409,806 (GRCm39)		probably benign	Het
Tbc1d10a	T	C	11: 4,163,680 (GRCm39)	C277R	probably damaging	Het
Trim55	A	C	3: 19,698,866 (GRCm39)	M32L	probably benign	Het
Unc5b	T	C	10: 60,614,698 (GRCm39)	T200A	probably benign	Het
Wrap53	A	T	11: 69,454,712 (GRCm39)	M219K	probably damaging	Het

Other mutations in Zfp790

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00229:Zfp790	APN	7	29,527,988 (GRCm39)	missense	probably benign	0.32
IGL00979:Zfp790	APN	7	29,529,034 (GRCm39)	missense	probably benign	0.00
IGL02286:Zfp790	APN	7	29,529,160 (GRCm39)	missense	possibly damaging	0.53
IGL03136:Zfp790	APN	7	29,529,320 (GRCm39)	nonsense	probably null
R0077:Zfp790	UTSW	7	29,524,300 (GRCm39)	missense	probably damaging	0.98
R1477:Zfp790	UTSW	7	29,522,525 (GRCm39)	start gained	probably benign
R1572:Zfp790	UTSW	7	29,527,564 (GRCm39)	missense	probably benign	0.33
R2015:Zfp790	UTSW	7	29,528,286 (GRCm39)	missense	probably benign	0.29
R4941:Zfp790	UTSW	7	29,528,916 (GRCm39)	missense	possibly damaging	0.83
R5019:Zfp790	UTSW	7	29,529,192 (GRCm39)	missense	probably benign	0.00
R5159:Zfp790	UTSW	7	29,529,192 (GRCm39)	missense	probably benign	0.00
R5160:Zfp790	UTSW	7	29,529,192 (GRCm39)	missense	probably benign	0.00
R5722:Zfp790	UTSW	7	29,529,514 (GRCm39)	nonsense	probably null
R5954:Zfp790	UTSW	7	29,528,929 (GRCm39)	missense	probably damaging	1.00
R6025:Zfp790	UTSW	7	29,528,970 (GRCm39)	missense	possibly damaging	0.71
R6312:Zfp790	UTSW	7	29,527,647 (GRCm39)	missense	probably damaging	1.00
R7392:Zfp790	UTSW	7	29,528,050 (GRCm39)	missense	possibly damaging	0.52
R7623:Zfp790	UTSW	7	29,525,130 (GRCm39)	nonsense	probably null
R8036:Zfp790	UTSW	7	29,528,346 (GRCm39)	missense	possibly damaging	0.92
R8175:Zfp790	UTSW	7	29,529,205 (GRCm39)	missense	possibly damaging	0.96
R8898:Zfp790	UTSW	7	29,522,525 (GRCm39)	start gained	probably benign
R8988:Zfp790	UTSW	7	29,527,593 (GRCm39)	missense	probably benign
R9176:Zfp790	UTSW	7	29,529,387 (GRCm39)	missense	probably benign	0.04
R9404:Zfp790	UTSW	7	29,525,185 (GRCm39)	missense	probably benign
R9519:Zfp790	UTSW	7	29,522,567 (GRCm39)	missense	unknown
Z1186:Zfp790	UTSW	7	29,529,109 (GRCm39)	missense	possibly damaging	0.53
Z1186:Zfp790	UTSW	7	29,529,258 (GRCm39)	missense	possibly damaging	0.92
Z1186:Zfp790	UTSW	7	29,529,208 (GRCm39)	missense	possibly damaging	0.72

Posted On

2012-11-27