Incidental Mutation 'R0899:Wap'
ID 83803
Institutional Source Beutler Lab
Gene Symbol Wap
Ensembl Gene ENSMUSG00000000381
Gene Name whey acidic protein
Synonyms
MMRRC Submission 039059-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0899 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 6585482-6588637 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 6586725 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 125 (T125A)
Ref Sequence ENSEMBL: ENSMUSP00000099974 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000102910]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000102910
AA Change: T125A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000099974
Gene: ENSMUSG00000000381
AA Change: T125A

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
internal_repeat_1 46 75 4.46e-5 PROSPERO
WAP 79 128 1.96e-21 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127341
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141868
Coding Region Coverage
  • 1x: 99.7%
  • 3x: 99.0%
  • 10x: 97.2%
  • 20x: 93.6%
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous mutants are phenotypically normal and fertile. Functional differentiation of mammary epithelium is normal and dams produce milk, but pups thrive poorly on milk lacking whey acidic protein. A normal variant determines a one amino acid change inWAP protein in YBR versus other strains. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5031439G07Rik T C 15: 84,833,459 (GRCm39) K442E probably damaging Het
Adamts1 G A 16: 85,594,940 (GRCm39) R340* probably null Het
Afg3l2 T C 18: 67,556,047 (GRCm39) N428S possibly damaging Het
Aqp12 G A 1: 92,934,332 (GRCm39) D70N probably damaging Het
Astn1 T A 1: 158,338,679 (GRCm39) C475* probably null Het
Atp2b1 G A 10: 98,852,893 (GRCm39) probably null Het
Cbln2 T C 18: 86,734,877 (GRCm39) S217P possibly damaging Het
Ces2h T C 8: 105,741,182 (GRCm39) L58P probably damaging Het
Cfap43 C T 19: 47,736,433 (GRCm39) G1353R possibly damaging Het
Crcp A G 5: 130,088,672 (GRCm39) M91V probably benign Het
Cubn A G 2: 13,367,139 (GRCm39) V1577A possibly damaging Het
Dthd1 A G 5: 63,000,271 (GRCm39) H531R probably benign Het
Fam120a G T 13: 49,039,219 (GRCm39) A979E possibly damaging Het
Fam3d A G 14: 8,364,863 (GRCm38) I16T probably damaging Het
Fat2 C T 11: 55,147,051 (GRCm39) G3982S probably damaging Het
Fbxo44 C G 4: 148,240,726 (GRCm39) R220S probably damaging Het
Fcnb T A 2: 27,966,791 (GRCm39) K247N probably damaging Het
Gtf2a1l A G 17: 88,976,152 (GRCm39) N5S Het
Htr3a T A 9: 48,812,752 (GRCm39) D229V possibly damaging Het
Ipo11 A C 13: 107,037,324 (GRCm39) L173* probably null Het
Jam3 C A 9: 27,010,253 (GRCm39) G244W probably damaging Het
Lypd11 C T 7: 24,422,737 (GRCm39) R112H probably benign Het
Mrpl52 C T 14: 54,664,541 (GRCm39) R12* probably null Het
Myo15a A G 11: 60,368,011 (GRCm39) Y257C possibly damaging Het
Myocd G A 11: 65,086,018 (GRCm39) P215L possibly damaging Het
Ndst1 T C 18: 60,840,954 (GRCm39) T243A probably benign Het
Obox5 A T 7: 15,492,800 (GRCm39) T252S probably benign Het
Or5m13b A G 2: 85,753,731 (GRCm39) T40A probably benign Het
Or6c75 T C 10: 129,337,301 (GRCm39) F183L probably damaging Het
Or7g34 A C 9: 19,477,843 (GRCm39) V276G probably damaging Het
Osbpl1a T C 18: 12,890,747 (GRCm39) S377G possibly damaging Het
Pfkl A G 10: 77,841,273 (GRCm39) probably null Het
Prdm16 A T 4: 154,613,366 (GRCm39) N20K probably damaging Het
Prkd1 A G 12: 50,431,976 (GRCm39) I589T probably damaging Het
Scnn1b G A 7: 121,516,938 (GRCm39) G525S probably damaging Het
Tktl2 G A 8: 66,964,999 (GRCm39) V186M probably damaging Het
Ttn A G 2: 76,718,329 (GRCm39) probably benign Het
Wdr86 C T 5: 24,923,005 (GRCm39) R229Q probably benign Het
Other mutations in Wap
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00971:Wap APN 11 6,586,808 (GRCm39) missense probably damaging 0.98
R1330:Wap UTSW 11 6,586,818 (GRCm39) missense unknown
R3783:Wap UTSW 11 6,588,550 (GRCm39) nonsense probably null
R3785:Wap UTSW 11 6,588,550 (GRCm39) nonsense probably null
R3786:Wap UTSW 11 6,588,550 (GRCm39) nonsense probably null
R3787:Wap UTSW 11 6,588,550 (GRCm39) nonsense probably null
R5022:Wap UTSW 11 6,587,339 (GRCm39) splice site probably benign
R5065:Wap UTSW 11 6,586,840 (GRCm39) missense probably damaging 0.96
R5664:Wap UTSW 11 6,588,609 (GRCm39) missense possibly damaging 0.86
R8112:Wap UTSW 11 6,586,724 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- AGGATTGGCTAGGACATTCTCCTCC -3'
(R):5'- GCTGCCTGACCATAAGACAGACTTC -3'

Sequencing Primer
(F):5'- CCTACCCTGGGACCTAGTC -3'
(R):5'- TTCAGTCATGGGGTCAGTAAAG -3'
Posted On 2013-11-08