Incidental Mutation 'R0900:Zfp750'
ID 83847
Institutional Source Beutler Lab
Gene Symbol Zfp750
Ensembl Gene ENSMUSG00000039238
Gene Name zinc finger protein 750
Synonyms A030007D23Rik
Accession Numbers
Essential gene? Possibly essential (E-score: 0.649) question?
Stock # R0900 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 121401804-121410159 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 121403807 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 356 (E356G)
Ref Sequence ENSEMBL: ENSMUSP00000089951 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000092298] [ENSMUST00000103013]
AlphaFold Q8BH05
Predicted Effect probably benign
Transcript: ENSMUST00000092298
AA Change: E356G

PolyPhen 2 Score 0.312 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000089951
Gene: ENSMUSG00000039238
AA Change: E356G

DomainStartEndE-ValueType
ZnF_C2H2 25 45 2.12e1 SMART
low complexity region 352 362 N/A INTRINSIC
low complexity region 689 702 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000103013
SMART Domains Protein: ENSMUSP00000099302
Gene: ENSMUSG00000039230

DomainStartEndE-ValueType
low complexity region 6 20 N/A INTRINSIC
low complexity region 45 62 N/A INTRINSIC
SCOP:d1b3ua_ 357 742 4e-20 SMART
Pfam:TFCD_C 900 1090 1.4e-74 PFAM
low complexity region 1113 1120 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000125167
SMART Domains Protein: ENSMUSP00000124735
Gene: ENSMUSG00000039230

DomainStartEndE-ValueType
low complexity region 36 58 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.5%
  • 3x: 99.1%
  • 10x: 98.0%
  • 20x: 96.7%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein with a nuclear localization site and a C2H2 zinc finger domain. Mutations in this gene have been associated with seborrhea-like dermatitis with psoriasiform elements. [provided by RefSeq, Jul 2008]
Allele List at MGI

All alleles(2) : Targeted(2)

Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb5 A T 12: 118,904,359 (GRCm39) F144I probably damaging Het
Als2cl A G 9: 110,719,496 (GRCm39) R468G possibly damaging Het
Arsk C A 13: 76,246,576 (GRCm39) probably benign Het
Cacna1d T C 14: 29,833,039 (GRCm39) H912R probably damaging Het
Ccr1 A T 9: 123,764,371 (GRCm39) V53D possibly damaging Het
Cfap91 G A 16: 38,156,764 (GRCm39) S47L possibly damaging Het
Clec2d G A 6: 129,160,076 (GRCm39) R30K probably benign Het
Col12a1 A G 9: 79,591,535 (GRCm39) V975A possibly damaging Het
Col4a1 AGCCAGGGATGCCAGG AGCCAGG 8: 11,268,014 (GRCm39) probably benign Het
Cul7 T C 17: 46,969,263 (GRCm39) S907P probably benign Het
Depdc1b A T 13: 108,498,794 (GRCm39) H159L possibly damaging Het
Dhx57 T C 17: 80,583,011 (GRCm39) H198R probably benign Het
Dpp7 T C 2: 25,246,311 (GRCm39) D10G probably damaging Het
Esp18 G A 17: 39,719,023 (GRCm39) M7I possibly damaging Het
Fam120a G T 13: 49,039,219 (GRCm39) A979E possibly damaging Het
Fam167a A G 14: 63,689,828 (GRCm39) T42A probably damaging Het
Gm973 A G 1: 59,605,827 (GRCm39) R553G probably benign Het
Ift140 T A 17: 25,254,786 (GRCm39) I422N probably benign Het
Jag1 CTTT CTTTT 2: 136,932,802 (GRCm39) probably null Het
Limk2 A G 11: 3,300,731 (GRCm39) F204L probably damaging Het
Lmo7 A G 14: 102,124,624 (GRCm39) D361G probably damaging Het
Muc2 CGTG CGTGTG 7: 141,699,185 (GRCm38) probably null Het
Nup98 T A 7: 101,809,923 (GRCm39) T536S probably damaging Het
Or52e2 T A 7: 102,804,520 (GRCm39) M145L probably benign Het
Parp14 G A 16: 35,677,130 (GRCm39) A946V probably benign Het
Pcdh18 A T 3: 49,711,252 (GRCm39) F21Y probably benign Het
Pcna-ps2 T A 19: 9,261,487 (GRCm39) Y249N probably damaging Het
Prkce A T 17: 86,932,886 (GRCm39) D622V probably damaging Het
Prss47 A C 13: 65,197,208 (GRCm39) V176G possibly damaging Het
Prss55 C T 14: 64,314,627 (GRCm39) R181H probably benign Het
Prtg A T 9: 72,752,225 (GRCm39) I204L probably benign Het
Pura T C 18: 36,420,720 (GRCm39) I169T probably damaging Het
Rttn C T 18: 89,119,815 (GRCm39) T1750I probably benign Het
Slc25a26 T A 6: 94,484,639 (GRCm39) S60T probably damaging Het
Tktl2 G A 8: 66,964,999 (GRCm39) V186M probably damaging Het
Tmem94 T A 11: 115,682,804 (GRCm39) C614S probably benign Het
Trim12a T C 7: 103,953,469 (GRCm39) N214S probably benign Het
Ube3c T C 5: 29,806,344 (GRCm39) Y329H probably benign Het
Ubxn2a T C 12: 4,952,257 (GRCm39) K2E probably damaging Het
Unc80 A T 1: 66,710,757 (GRCm39) E2675D probably benign Het
Usf3 C T 16: 44,036,321 (GRCm39) P267L probably benign Het
Vmn1r129 A T 7: 21,094,635 (GRCm39) Y194* probably null Het
Other mutations in Zfp750
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01011:Zfp750 APN 11 121,403,922 (GRCm39) missense probably benign 0.07
IGL01450:Zfp750 APN 11 121,403,855 (GRCm39) missense probably benign
IGL01467:Zfp750 APN 11 121,403,767 (GRCm39) nonsense probably null
IGL01538:Zfp750 APN 11 121,402,991 (GRCm39) missense probably benign 0.02
IGL01732:Zfp750 APN 11 121,403,819 (GRCm39) missense probably benign 0.01
IGL01793:Zfp750 APN 11 121,404,810 (GRCm39) missense probably damaging 1.00
IGL02004:Zfp750 APN 11 121,402,975 (GRCm39) missense probably benign 0.00
IGL02334:Zfp750 APN 11 121,402,837 (GRCm39) missense probably benign 0.03
IGL02441:Zfp750 APN 11 121,404,455 (GRCm39) missense probably benign 0.00
IGL03173:Zfp750 APN 11 121,404,651 (GRCm39) nonsense probably null
IGL03229:Zfp750 APN 11 121,403,778 (GRCm39) missense possibly damaging 0.87
IGL03244:Zfp750 APN 11 121,404,513 (GRCm39) nonsense probably null
IGL03351:Zfp750 APN 11 121,404,173 (GRCm39) missense probably damaging 1.00
IGL03390:Zfp750 APN 11 121,402,770 (GRCm39) nonsense probably null
P0016:Zfp750 UTSW 11 121,404,804 (GRCm39) nonsense probably null
R0800:Zfp750 UTSW 11 121,402,838 (GRCm39) missense probably benign
R1444:Zfp750 UTSW 11 121,402,873 (GRCm39) missense probably damaging 1.00
R1470:Zfp750 UTSW 11 121,402,819 (GRCm39) missense probably benign
R1470:Zfp750 UTSW 11 121,402,819 (GRCm39) missense probably benign
R2008:Zfp750 UTSW 11 121,403,951 (GRCm39) missense possibly damaging 0.92
R2009:Zfp750 UTSW 11 121,403,951 (GRCm39) missense possibly damaging 0.92
R2134:Zfp750 UTSW 11 121,404,758 (GRCm39) missense probably damaging 1.00
R2415:Zfp750 UTSW 11 121,403,305 (GRCm39) missense probably benign 0.01
R2912:Zfp750 UTSW 11 121,403,153 (GRCm39) missense probably benign 0.00
R3611:Zfp750 UTSW 11 121,402,981 (GRCm39) missense probably benign 0.03
R4648:Zfp750 UTSW 11 121,402,706 (GRCm39) missense probably benign 0.00
R5068:Zfp750 UTSW 11 121,403,021 (GRCm39) missense probably benign 0.02
R5487:Zfp750 UTSW 11 121,404,558 (GRCm39) missense probably benign 0.00
R7953:Zfp750 UTSW 11 121,402,706 (GRCm39) missense probably benign 0.00
R8013:Zfp750 UTSW 11 121,403,843 (GRCm39) missense possibly damaging 0.83
R8014:Zfp750 UTSW 11 121,403,843 (GRCm39) missense possibly damaging 0.83
R8043:Zfp750 UTSW 11 121,402,706 (GRCm39) missense probably benign 0.00
R8351:Zfp750 UTSW 11 121,404,135 (GRCm39) missense probably benign 0.01
R8451:Zfp750 UTSW 11 121,404,135 (GRCm39) missense probably benign 0.01
R8694:Zfp750 UTSW 11 121,404,456 (GRCm39) missense possibly damaging 0.57
R9029:Zfp750 UTSW 11 121,403,149 (GRCm39) missense probably benign 0.08
R9128:Zfp750 UTSW 11 121,404,674 (GRCm39) missense probably benign 0.30
R9166:Zfp750 UTSW 11 121,403,980 (GRCm39) missense probably damaging 1.00
R9429:Zfp750 UTSW 11 121,404,693 (GRCm39) missense probably damaging 1.00
X0057:Zfp750 UTSW 11 121,404,104 (GRCm39) missense probably damaging 0.96
Predicted Primers PCR Primer
(F):5'- GGCTGCTTTGTTTGAGAGGTCACAC -3'
(R):5'- CAAAGACACTTCCTGTCTCCTGCTG -3'

Sequencing Primer
(F):5'- AATGTTTGGCTTGTTTGGGTGAAG -3'
(R):5'- TGCTGGGCCAATTCCCAAG -3'
Posted On 2013-11-08