Incidental Mutation 'R0903:Or8c11'
ID 83885
Institutional Source Beutler Lab
Gene Symbol Or8c11
Ensembl Gene ENSMUSG00000096757
Gene Name olfactory receptor family 8 subfamily C member 11
Synonyms GA_x6K02T2PVTD-32071567-32072508, Olfr900, GA_x6K02T2MYUG-9124-8183, MOR170-2, MOR170-13, MOR170-15, Olfr251
MMRRC Submission 039061-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.075) question?
Stock # R0903 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 38289179-38290129 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to G at 38290097 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Valine at position 301 (L301V)
Ref Sequence ENSEMBL: ENSMUSP00000149583 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072731] [ENSMUST00000214865]
AlphaFold E9Q891
Predicted Effect probably benign
Transcript: ENSMUST00000072731
AA Change: L307V

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000072514
Gene: ENSMUSG00000096757
AA Change: L307V

DomainStartEndE-ValueType
Pfam:7tm_4 37 313 9.8e-50 PFAM
Pfam:7tm_1 47 296 4.2e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214865
AA Change: L301V

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.3%
  • 20x: 94.9%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 16 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Asap3 A G 4: 135,965,687 (GRCm39) N399S probably benign Het
Camk4 T A 18: 33,315,383 (GRCm39) F303L probably benign Het
Cntn2 CCAGCAGCAGCAGCAGCA CCAGCAGCAGCAGCA 1: 132,461,422 (GRCm39) probably benign Het
Hmg20b C T 10: 81,184,329 (GRCm39) probably null Het
Itih5 G A 2: 10,253,999 (GRCm39) R750Q probably benign Het
Kif13a T C 13: 47,082,735 (GRCm39) T35A possibly damaging Het
Klri2 A G 6: 129,710,739 (GRCm39) S127P possibly damaging Het
Lgr6 C T 1: 134,921,748 (GRCm39) A199T probably damaging Het
Mmp3 A G 9: 7,445,994 (GRCm39) M33V probably benign Het
Mycbp2 T C 14: 103,513,293 (GRCm39) H821R probably damaging Het
Mzf1 C A 7: 12,786,698 (GRCm39) R124L possibly damaging Het
Or4k35 T A 2: 111,100,701 (GRCm39) I4L probably benign Het
Scrib A T 15: 75,938,704 (GRCm39) W203R possibly damaging Het
Sspo A G 6: 48,432,242 (GRCm39) probably null Het
Ssx2ip G T 3: 146,136,732 (GRCm39) V327L probably benign Het
Ugt2a3 A T 5: 87,475,570 (GRCm39) F354Y probably benign Het
Other mutations in Or8c11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02013:Or8c11 APN 9 38,289,373 (GRCm39) missense probably benign 0.31
IGL02131:Or8c11 APN 9 38,289,203 (GRCm39) missense probably benign 0.01
IGL02311:Or8c11 APN 9 38,289,194 (GRCm39) nonsense probably null
IGL02377:Or8c11 APN 9 38,289,542 (GRCm39) missense probably damaging 1.00
R0284:Or8c11 UTSW 9 38,289,880 (GRCm39) missense probably benign 0.00
R0412:Or8c11 UTSW 9 38,290,090 (GRCm39) missense probably damaging 0.98
R1664:Or8c11 UTSW 9 38,289,548 (GRCm39) missense possibly damaging 0.93
R2902:Or8c11 UTSW 9 38,289,337 (GRCm39) missense possibly damaging 0.89
R3970:Or8c11 UTSW 9 38,289,222 (GRCm39) missense probably damaging 0.98
R4191:Or8c11 UTSW 9 38,289,648 (GRCm39) missense probably damaging 0.98
R4650:Or8c11 UTSW 9 38,289,699 (GRCm39) missense probably damaging 1.00
R4910:Or8c11 UTSW 9 38,290,038 (GRCm39) missense probably null 0.98
R5256:Or8c11 UTSW 9 38,289,213 (GRCm39) missense probably benign 0.00
R5385:Or8c11 UTSW 9 38,289,281 (GRCm39) missense probably benign
R5386:Or8c11 UTSW 9 38,289,281 (GRCm39) missense probably benign
R6005:Or8c11 UTSW 9 38,289,605 (GRCm39) missense probably damaging 1.00
R6268:Or8c11 UTSW 9 38,289,384 (GRCm39) missense probably benign 0.10
R6486:Or8c11 UTSW 9 38,289,200 (GRCm39) missense probably benign
R7019:Or8c11 UTSW 9 38,290,098 (GRCm39) missense possibly damaging 0.89
R7045:Or8c11 UTSW 9 38,289,729 (GRCm39) missense probably damaging 0.99
R7120:Or8c11 UTSW 9 38,289,945 (GRCm39) missense probably damaging 1.00
R7329:Or8c11 UTSW 9 38,289,456 (GRCm39) missense probably benign 0.00
R7703:Or8c11 UTSW 9 38,289,357 (GRCm39) missense probably benign 0.01
R8333:Or8c11 UTSW 9 38,289,912 (GRCm39) missense probably damaging 0.98
R8352:Or8c11 UTSW 9 38,289,647 (GRCm39) missense probably benign 0.01
R8452:Or8c11 UTSW 9 38,289,647 (GRCm39) missense probably benign 0.01
R8461:Or8c11 UTSW 9 38,289,777 (GRCm39) missense probably damaging 0.96
R8870:Or8c11 UTSW 9 38,289,720 (GRCm39) missense probably benign 0.16
Predicted Primers PCR Primer
(F):5'- TCAAAAGCCCTGGGCACTTGTG -3'
(R):5'- TGGCAGTGATCAACATTCTGGAGC -3'

Sequencing Primer
(F):5'- GGGTCCCACATCATAACTGTTAG -3'
(R):5'- GTGATCAACATTCTGGAGCAATATG -3'
Posted On 2013-11-08