Incidental Mutation 'R0967:Mos'
ID 83896
Institutional Source Beutler Lab
Gene Symbol Mos
Ensembl Gene ENSMUSG00000078365
Gene Name Moloney sarcoma oncogene
Synonyms c-mos
MMRRC Submission 039096-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0967 (G1)
Quality Score 182
Status Validated
Chromosome 4
Chromosomal Location 3870658-3872105 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 3870932 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 295 (S295P)
Ref Sequence ENSEMBL: ENSMUSP00000100789 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000105158]
AlphaFold P00536
Predicted Effect probably benign
Transcript: ENSMUST00000105158
AA Change: S295P

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000100789
Gene: ENSMUSG00000078365
AA Change: S295P

DomainStartEndE-ValueType
low complexity region 39 54 N/A INTRINSIC
Pfam:Pkinase_Tyr 63 335 9e-41 PFAM
Pfam:Pkinase 64 334 6.3e-43 PFAM
Meta Mutation Damage Score 0.0894 question?
Coding Region Coverage
  • 1x: 99.6%
  • 3x: 98.7%
  • 10x: 96.1%
  • 20x: 90.5%
Validation Efficiency 100% (44/44)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] MOS is a serine/threonine kinase that activates the MAP kinase cascade through direct phosphorylation of the MAP kinase activator MEK (MAP2K1; MIM 176872) (Prasad et al., 2008 [PubMed 18246541]).[supplied by OMIM, Jul 2009]
PHENOTYPE: Mutations that inactivate the gene result in female infertility and an increased susceptibility to tumors. Oocytes progress through meiosis II without arrest and undergo spontaneous parthenogenetic activation. Male mice are fertile and show no spermatogenic defects. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts19 G T 18: 59,105,812 (GRCm39) E736* probably null Het
Atxn7l3 C G 11: 102,183,261 (GRCm39) probably benign Het
Camk1g T C 1: 193,032,604 (GRCm39) E269G probably damaging Het
Ccrl2 G A 9: 110,884,754 (GRCm39) T248M probably benign Het
Chd9 T C 8: 91,716,107 (GRCm39) S421P probably damaging Het
Cndp1 G A 18: 84,652,777 (GRCm39) probably benign Het
Cplane2 T C 4: 140,947,162 (GRCm39) M181T probably benign Het
Csmd3 T C 15: 47,721,227 (GRCm39) E1468G probably null Het
Cyc1 T C 15: 76,229,848 (GRCm39) probably benign Het
Fli1 T A 9: 32,372,745 (GRCm39) T98S probably benign Het
Gk2 T C 5: 97,604,155 (GRCm39) S228G probably benign Het
Gse1 T A 8: 121,297,594 (GRCm39) probably benign Het
Hgf T A 5: 16,798,839 (GRCm39) probably benign Het
Hif1a G A 12: 73,984,444 (GRCm39) V300I possibly damaging Het
Hsd17b4 C A 18: 50,316,328 (GRCm39) H652N probably benign Het
Hsh2d G A 8: 72,954,304 (GRCm39) D229N probably benign Het
Kif5c T A 2: 49,588,128 (GRCm39) probably benign Het
Lgr6 T C 1: 134,921,750 (GRCm39) Y198C probably damaging Het
Lpcat2b T A 5: 107,582,084 (GRCm39) M471K possibly damaging Het
Med21 A G 6: 146,551,697 (GRCm39) E116G probably benign Het
Ms4a15 A T 19: 10,956,685 (GRCm39) V209E probably damaging Het
Mttp A G 3: 137,798,484 (GRCm39) V804A probably benign Het
Or10ah1-ps1 A G 5: 143,123,594 (GRCm39) M121T probably damaging Het
Or52n4b T C 7: 108,143,996 (GRCm39) I86T probably damaging Het
Or5ac23 T A 16: 59,149,546 (GRCm39) T109S possibly damaging Het
Plagl1 T C 10: 13,003,986 (GRCm39) probably benign Het
Prpf8 T A 11: 75,385,256 (GRCm39) V797E probably damaging Het
Rars2 A G 4: 34,646,587 (GRCm39) D284G probably benign Het
Rassf8 T C 6: 145,765,676 (GRCm39) probably benign Het
Rfx3 A G 19: 27,783,751 (GRCm39) probably benign Het
Ripk4 A T 16: 97,545,372 (GRCm39) M362K probably damaging Het
Rubcn C A 16: 32,646,087 (GRCm39) E815D probably benign Het
Scn8a A G 15: 100,933,527 (GRCm39) Y1577C probably damaging Het
Sec24b C T 3: 129,790,431 (GRCm39) R698Q probably damaging Het
Ssc5d T A 7: 4,947,342 (GRCm39) L1232* probably null Het
Usp7 A T 16: 8,514,518 (GRCm39) probably benign Het
Vmn2r51 T G 7: 9,834,012 (GRCm39) H342P probably damaging Het
Vmn2r70 A G 7: 85,208,827 (GRCm39) M550T probably damaging Het
Vmn2r81 T C 10: 79,083,857 (GRCm39) probably benign Het
Zc3h13 T C 14: 75,581,179 (GRCm39) I1722T possibly damaging Het
Other mutations in Mos
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00848:Mos APN 4 3,871,459 (GRCm39) missense probably damaging 1.00
IGL01302:Mos APN 4 3,871,815 (GRCm39) utr 5 prime probably benign
IGL01739:Mos APN 4 3,871,816 (GRCm39) utr 5 prime probably benign
IGL01867:Mos APN 4 3,870,845 (GRCm39) missense probably benign 0.33
IGL02647:Mos APN 4 3,870,961 (GRCm39) missense probably damaging 1.00
PIT4418001:Mos UTSW 4 3,870,814 (GRCm39) missense possibly damaging 0.86
R4927:Mos UTSW 4 3,871,093 (GRCm39) missense probably damaging 1.00
R5729:Mos UTSW 4 3,870,971 (GRCm39) missense probably benign 0.01
R6947:Mos UTSW 4 3,871,585 (GRCm39) missense probably damaging 1.00
R8359:Mos UTSW 4 3,871,097 (GRCm39) missense probably damaging 1.00
R8526:Mos UTSW 4 3,871,709 (GRCm39) missense probably damaging 0.99
R9106:Mos UTSW 4 3,871,457 (GRCm39) missense probably benign 0.44
R9336:Mos UTSW 4 3,870,886 (GRCm39) missense probably damaging 1.00
R9347:Mos UTSW 4 3,871,763 (GRCm39) missense probably benign 0.02
R9683:Mos UTSW 4 3,871,186 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- TCTACATCGGCTCGATGGAGTCAG -3'
(R):5'- TCACAAAGCATTTTGCACTTGGACC -3'

Sequencing Primer
(F):5'- CTCGATGGAGTCAGCCTAGTG -3'
(R):5'- CTGAAGCCAGCGAACATTTTG -3'
Posted On 2013-11-08