Incidental Mutation 'R0969:Ccl20'
ID 83970
Institutional Source Beutler Lab
Gene Symbol Ccl20
Ensembl Gene ENSMUSG00000026166
Gene Name C-C motif chemokine ligand 20
Synonyms exodus-1, MIP-3[a], MIP3A, ST38, Scya20, MIP-3A, CKb4
MMRRC Submission 039098-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.152) question?
Stock # R0969 (G1)
Quality Score 225
Status Validated
Chromosome 1
Chromosomal Location 83094487-83096888 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to A at 83095638 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000139923 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027351] [ENSMUST00000113437] [ENSMUST00000186832]
AlphaFold O89093
Predicted Effect probably benign
Transcript: ENSMUST00000027351
SMART Domains Protein: ENSMUSP00000027351
Gene: ENSMUSG00000026166

DomainStartEndE-ValueType
signal peptide 1 27 N/A INTRINSIC
SCY 30 90 9.36e-19 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000113437
SMART Domains Protein: ENSMUSP00000109064
Gene: ENSMUSG00000026166

DomainStartEndE-ValueType
low complexity region 8 21 N/A INTRINSIC
SCY 30 90 9.36e-19 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000186832
SMART Domains Protein: ENSMUSP00000139923
Gene: ENSMUSG00000026166

DomainStartEndE-ValueType
low complexity region 8 21 N/A INTRINSIC
SCY 29 89 9.36e-19 SMART
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.9%
  • 10x: 97.5%
  • 20x: 95.7%
Validation Efficiency 97% (38/39)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene displays chemotactic activity for lymphocytes and can repress proliferation of myeloid progenitors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acot11 C T 4: 106,617,277 (GRCm39) probably null Het
Afg1l T C 10: 42,194,617 (GRCm39) T392A probably damaging Het
Ccdc66 A G 14: 27,219,319 (GRCm39) S146P probably damaging Het
Cd2 T A 3: 101,183,371 (GRCm39) I313F probably benign Het
Cep350 A T 1: 155,816,572 (GRCm39) D374E possibly damaging Het
Cep85l T C 10: 53,157,592 (GRCm39) K602E probably benign Het
Cndp1 G A 18: 84,652,777 (GRCm39) probably benign Het
Col1a2 G A 6: 4,518,822 (GRCm39) probably benign Het
Dhx8 T C 11: 101,630,526 (GRCm39) probably benign Het
Epha3 A T 16: 63,386,999 (GRCm39) L878Q probably damaging Het
F2rl2 A T 13: 95,837,461 (GRCm39) T169S probably damaging Het
Gpx3 T C 11: 54,799,852 (GRCm39) probably benign Het
Ipo5 T A 14: 121,181,937 (GRCm39) V1010D possibly damaging Het
Nipbl A T 15: 8,321,712 (GRCm39) L2647Q probably damaging Het
Obscn T C 11: 59,022,472 (GRCm39) R758G possibly damaging Het
Or5d18 T C 2: 87,864,592 (GRCm39) D297G probably damaging Het
Pcnt T C 10: 76,263,785 (GRCm39) E393G probably damaging Het
Pibf1 C A 14: 99,433,822 (GRCm39) Q590K probably benign Het
Pkd1l1 T C 11: 8,886,898 (GRCm39) D367G probably damaging Het
Pnpla7 T C 2: 24,940,965 (GRCm39) Y1106H probably damaging Het
Slc35e1 T C 8: 73,246,415 (GRCm39) probably benign Het
Slco5a1 C T 1: 13,060,116 (GRCm39) A202T probably damaging Het
Slco6c1 A C 1: 97,047,685 (GRCm39) I206R probably benign Het
Sned1 G A 1: 93,209,376 (GRCm39) V830M possibly damaging Het
Srek1 G A 13: 103,889,011 (GRCm39) probably benign Het
St8sia6 T A 2: 13,701,680 (GRCm39) R112S probably benign Het
Suclg1 T A 6: 73,248,099 (GRCm39) H273Q probably benign Het
Taf2 T A 15: 54,894,553 (GRCm39) probably null Het
Tctn1 A G 5: 122,379,840 (GRCm39) V566A probably benign Het
Trpm4 A G 7: 44,977,331 (GRCm39) probably benign Het
Trpv3 C T 11: 73,169,764 (GRCm39) Q112* probably null Het
Ttll8 T C 15: 88,818,138 (GRCm39) Y179C probably damaging Het
Ugt2b38 T G 5: 87,560,232 (GRCm39) N361H probably damaging Het
Upk1b A G 16: 38,607,661 (GRCm39) probably benign Het
Zfp961 T G 8: 72,722,139 (GRCm39) H217Q probably damaging Het
Other mutations in Ccl20
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02864:Ccl20 APN 1 83,095,799 (GRCm39) critical splice donor site probably null
IGL03372:Ccl20 APN 1 83,095,597 (GRCm39) missense probably benign 0.03
R1794:Ccl20 UTSW 1 83,095,550 (GRCm39) missense possibly damaging 0.74
R1818:Ccl20 UTSW 1 83,095,529 (GRCm39) missense probably damaging 0.96
R1897:Ccl20 UTSW 1 83,095,616 (GRCm39) missense probably damaging 1.00
R2001:Ccl20 UTSW 1 83,095,576 (GRCm39) frame shift probably null
R4885:Ccl20 UTSW 1 83,095,580 (GRCm39) missense possibly damaging 0.94
R7062:Ccl20 UTSW 1 83,095,535 (GRCm39) missense probably damaging 1.00
R8160:Ccl20 UTSW 1 83,095,543 (GRCm39) missense
R9349:Ccl20 UTSW 1 83,095,586 (GRCm39) missense
Predicted Primers PCR Primer
(F):5'- AGCCAATACAACAGCCCTGGAGTG -3'
(R):5'- AGGAGGTTCACAGCCCTTTTCACC -3'

Sequencing Primer
(F):5'- TTTCTTACTAGAGATGGCGAGAAGC -3'
(R):5'- ACCCAGTTCTGCTTTGGATCAG -3'
Posted On 2013-11-08