Incidental Mutation 'R0969:Zfp961'
| ID |
83984 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp961
|
| Ensembl Gene |
ENSMUSG00000052446 |
| Gene Name |
zinc finger protein 961 |
| Synonyms |
A230105L22Rik, BC049349 |
| MMRRC Submission |
039098-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R0969 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
8 |
| Chromosomal Location |
72704910-72724177 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to G
at 72722139 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Glutamine
at position 217
(H217Q)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000105623
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000109997]
[ENSMUST00000131237]
[ENSMUST00000132848]
[ENSMUST00000136516]
[ENSMUST00000138304]
[ENSMUST00000145256]
|
| AlphaFold |
E9Q4R5 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000109997
AA Change: H217Q
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000105623
Gene: ENSMUSG00000052446
AA Change: H217Q
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
25 |
82 |
1.14e-18 |
SMART |
|
ZnF_C2H2
|
144 |
166 |
1.69e-3 |
SMART |
|
ZnF_C2H2
|
172 |
194 |
3.07e-1 |
SMART |
|
ZnF_C2H2
|
199 |
221 |
1.36e-2 |
SMART |
|
ZnF_C2H2
|
226 |
248 |
3.29e-1 |
SMART |
|
ZnF_C2H2
|
254 |
276 |
3.34e-2 |
SMART |
|
ZnF_C2H2
|
282 |
304 |
9.58e-3 |
SMART |
|
ZnF_C2H2
|
310 |
332 |
2.17e-1 |
SMART |
|
ZnF_C2H2
|
338 |
360 |
1.04e-3 |
SMART |
|
ZnF_C2H2
|
366 |
388 |
2.24e-3 |
SMART |
|
ZnF_C2H2
|
394 |
416 |
2.24e-3 |
SMART |
|
ZnF_C2H2
|
421 |
443 |
4.61e-5 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000131237
AA Change: H198Q
PolyPhen 2
Score 0.711 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000122942
Gene: ENSMUSG00000052446
AA Change: H198Q
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
6 |
63 |
1.14e-18 |
SMART |
|
ZnF_C2H2
|
125 |
147 |
1.69e-3 |
SMART |
|
ZnF_C2H2
|
153 |
175 |
3.07e-1 |
SMART |
|
ZnF_C2H2
|
180 |
202 |
1.36e-2 |
SMART |
|
ZnF_C2H2
|
207 |
229 |
3.29e-1 |
SMART |
|
ZnF_C2H2
|
235 |
257 |
3.34e-2 |
SMART |
|
ZnF_C2H2
|
263 |
285 |
9.58e-3 |
SMART |
|
ZnF_C2H2
|
291 |
313 |
2.17e-1 |
SMART |
|
ZnF_C2H2
|
319 |
341 |
1.04e-3 |
SMART |
|
ZnF_C2H2
|
347 |
369 |
2.24e-3 |
SMART |
|
ZnF_C2H2
|
375 |
397 |
2.24e-3 |
SMART |
|
ZnF_C2H2
|
402 |
424 |
4.61e-5 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000132848
|
| SMART Domains |
Protein: ENSMUSP00000114730
Gene: ENSMUSG00000052446
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
25 |
82 |
1.14e-18 |
SMART |
|
ZnF_C2H2
|
144 |
166 |
1.69e-3 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000136516
|
| SMART Domains |
Protein: ENSMUSP00000122589
Gene: ENSMUSG00000052446
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
25 |
82 |
1.14e-18 |
SMART |
|
ZnF_C2H2
|
144 |
166 |
1.69e-3 |
SMART |
|
ZnF_C2H2
|
172 |
194 |
3.07e-1 |
SMART |
|
ZnF_C2H2
|
199 |
221 |
1.36e-2 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000136878
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000138304
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000139781
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000151168
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000144807
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000145256
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000147033
|
| Meta Mutation Damage Score |
0.4727 |
| Coding Region Coverage |
- 1x: 99.4%
- 3x: 98.9%
- 10x: 97.5%
- 20x: 95.7%
|
| Validation Efficiency |
97% (38/39) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 35 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acot11 |
C |
T |
4: 106,617,277 (GRCm39) |
|
probably null |
Het |
| Afg1l |
T |
C |
10: 42,194,617 (GRCm39) |
T392A |
probably damaging |
Het |
| Ccdc66 |
A |
G |
14: 27,219,319 (GRCm39) |
S146P |
probably damaging |
Het |
| Ccl20 |
T |
A |
1: 83,095,638 (GRCm39) |
|
probably benign |
Het |
| Cd2 |
T |
A |
3: 101,183,371 (GRCm39) |
I313F |
probably benign |
Het |
| Cep350 |
A |
T |
1: 155,816,572 (GRCm39) |
D374E |
possibly damaging |
Het |
| Cep85l |
T |
C |
10: 53,157,592 (GRCm39) |
K602E |
probably benign |
Het |
| Cndp1 |
G |
A |
18: 84,652,777 (GRCm39) |
|
probably benign |
Het |
| Col1a2 |
G |
A |
6: 4,518,822 (GRCm39) |
|
probably benign |
Het |
| Dhx8 |
T |
C |
11: 101,630,526 (GRCm39) |
|
probably benign |
Het |
| Epha3 |
A |
T |
16: 63,386,999 (GRCm39) |
L878Q |
probably damaging |
Het |
| F2rl2 |
A |
T |
13: 95,837,461 (GRCm39) |
T169S |
probably damaging |
Het |
| Gpx3 |
T |
C |
11: 54,799,852 (GRCm39) |
|
probably benign |
Het |
| Ipo5 |
T |
A |
14: 121,181,937 (GRCm39) |
V1010D |
possibly damaging |
Het |
| Nipbl |
A |
T |
15: 8,321,712 (GRCm39) |
L2647Q |
probably damaging |
Het |
| Obscn |
T |
C |
11: 59,022,472 (GRCm39) |
R758G |
possibly damaging |
Het |
| Or5d18 |
T |
C |
2: 87,864,592 (GRCm39) |
D297G |
probably damaging |
Het |
| Pcnt |
T |
C |
10: 76,263,785 (GRCm39) |
E393G |
probably damaging |
Het |
| Pibf1 |
C |
A |
14: 99,433,822 (GRCm39) |
Q590K |
probably benign |
Het |
| Pkd1l1 |
T |
C |
11: 8,886,898 (GRCm39) |
D367G |
probably damaging |
Het |
| Pnpla7 |
T |
C |
2: 24,940,965 (GRCm39) |
Y1106H |
probably damaging |
Het |
| Slc35e1 |
T |
C |
8: 73,246,415 (GRCm39) |
|
probably benign |
Het |
| Slco5a1 |
C |
T |
1: 13,060,116 (GRCm39) |
A202T |
probably damaging |
Het |
| Slco6c1 |
A |
C |
1: 97,047,685 (GRCm39) |
I206R |
probably benign |
Het |
| Sned1 |
G |
A |
1: 93,209,376 (GRCm39) |
V830M |
possibly damaging |
Het |
| Srek1 |
G |
A |
13: 103,889,011 (GRCm39) |
|
probably benign |
Het |
| St8sia6 |
T |
A |
2: 13,701,680 (GRCm39) |
R112S |
probably benign |
Het |
| Suclg1 |
T |
A |
6: 73,248,099 (GRCm39) |
H273Q |
probably benign |
Het |
| Taf2 |
T |
A |
15: 54,894,553 (GRCm39) |
|
probably null |
Het |
| Tctn1 |
A |
G |
5: 122,379,840 (GRCm39) |
V566A |
probably benign |
Het |
| Trpm4 |
A |
G |
7: 44,977,331 (GRCm39) |
|
probably benign |
Het |
| Trpv3 |
C |
T |
11: 73,169,764 (GRCm39) |
Q112* |
probably null |
Het |
| Ttll8 |
T |
C |
15: 88,818,138 (GRCm39) |
Y179C |
probably damaging |
Het |
| Ugt2b38 |
T |
G |
5: 87,560,232 (GRCm39) |
N361H |
probably damaging |
Het |
| Upk1b |
A |
G |
16: 38,607,661 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Zfp961 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00595:Zfp961
|
APN |
8 |
72,722,272 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00801:Zfp961
|
APN |
8 |
72,719,732 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00825:Zfp961
|
APN |
8 |
72,721,888 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL01405:Zfp961
|
APN |
8 |
72,721,778 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
IGL03100:Zfp961
|
APN |
8 |
72,721,754 (GRCm39) |
makesense |
probably null |
|
|
R4851:Zfp961
|
UTSW |
8 |
72,722,847 (GRCm39) |
unclassified |
probably benign |
|
|
R5502:Zfp961
|
UTSW |
8 |
72,721,903 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5813:Zfp961
|
UTSW |
8 |
72,722,070 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6762:Zfp961
|
UTSW |
8 |
72,719,958 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R6902:Zfp961
|
UTSW |
8 |
72,722,522 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7858:Zfp961
|
UTSW |
8 |
72,704,949 (GRCm39) |
missense |
unknown |
|
|
R8749:Zfp961
|
UTSW |
8 |
72,719,686 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9718:Zfp961
|
UTSW |
8 |
72,721,933 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
X0027:Zfp961
|
UTSW |
8 |
72,721,793 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGTCACACTGCCAGTCAATCATCC -3'
(R):5'- GCCAGAAGTGAATGTCTTTCCGCAC -3'
Sequencing Primer
(F):5'- ggctcccttaaaaaacataaaaagac -3'
(R):5'- gttttcccacattgcttacattc -3'
|
| Posted On |
2013-11-08 |
Incidental Mutation