Incidental Mutation 'IGL01373:Or11g2'
ID 84070
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or11g2
Ensembl Gene ENSMUSG00000053815
Gene Name olfactory receptor family 11 subfamily G member 2
Synonyms MOR106-13P, GA_x6K02T2PMLR-6326342-6327313, Olfr744
Accession Numbers
Essential gene? Probably non essential (E-score: 0.093) question?
Stock # IGL01373
Quality Score
Status
Chromosome 14
Chromosomal Location 50855681-50856652 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 50856069 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 130 (I130N)
Ref Sequence ENSEMBL: ENSMUSP00000148954 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000066457] [ENSMUST00000213668] [ENSMUST00000216690]
AlphaFold Q7TRM0
Predicted Effect probably damaging
Transcript: ENSMUST00000066457
AA Change: I130N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000066496
Gene: ENSMUSG00000053815
AA Change: I130N

DomainStartEndE-ValueType
Pfam:7tm_4 35 312 2.9e-48 PFAM
Pfam:7tm_1 45 294 1.4e-19 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213668
AA Change: I130N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000216690
AA Change: I130N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsm4 C T 7: 119,310,642 (GRCm39) R510* probably null Het
Adamts12 A T 15: 11,310,816 (GRCm39) E1024D probably benign Het
Aff2 T A X: 68,911,335 (GRCm39) D1239E possibly damaging Het
Agps T C 2: 75,683,128 (GRCm39) V151A probably benign Het
Cables1 A T 18: 12,021,821 (GRCm39) R276S probably damaging Het
Cep72 A G 13: 74,207,578 (GRCm39) S64P probably damaging Het
Cmah A T 13: 24,614,532 (GRCm39) D159V probably damaging Het
Cox6a1 C A 5: 115,483,898 (GRCm39) probably benign Het
Cpxm1 T C 2: 130,236,055 (GRCm39) E369G probably damaging Het
Dnah6 A G 6: 73,051,731 (GRCm39) L3021P probably benign Het
Esyt1 T C 10: 128,354,810 (GRCm39) E530G possibly damaging Het
Fancd2 A G 6: 113,530,713 (GRCm39) I449V probably benign Het
Fbxw24 C T 9: 109,452,701 (GRCm39) G98D probably damaging Het
Folh1 T C 7: 86,395,350 (GRCm39) I361V probably benign Het
Gpr19 T A 6: 134,847,284 (GRCm39) H41L possibly damaging Het
Kcnq4 A G 4: 120,574,229 (GRCm39) V143A probably damaging Het
Larp7-ps A G 4: 92,079,862 (GRCm39) V42A probably damaging Het
Lmcd1 A G 6: 112,287,586 (GRCm39) I91V probably benign Het
Lpin3 G T 2: 160,745,649 (GRCm39) D651Y probably damaging Het
Ms4a6b A T 19: 11,506,871 (GRCm39) H220L possibly damaging Het
Mxd4 G A 5: 34,341,690 (GRCm39) probably benign Het
Nxnl2 T C 13: 51,325,488 (GRCm39) F44L probably damaging Het
Or2ag16 T C 7: 106,351,653 (GRCm39) probably benign Het
Pcdhb20 A T 18: 37,639,621 (GRCm39) R716W probably benign Het
Pcx T A 19: 4,670,263 (GRCm39) probably null Het
Plekhf1 T C 7: 37,921,221 (GRCm39) T116A probably benign Het
Psmb2 G T 4: 126,580,885 (GRCm39) R93L probably damaging Het
Pstpip2 T A 18: 77,922,916 (GRCm39) L42* probably null Het
Ptpn22 A T 3: 103,793,520 (GRCm39) D557V probably damaging Het
Rbbp5 G A 1: 132,420,339 (GRCm39) V191I probably benign Het
Rgs1 T A 1: 144,121,116 (GRCm39) D185V probably damaging Het
Selenoh A G 2: 84,500,938 (GRCm39) probably benign Het
Slc6a5 C T 7: 49,567,481 (GRCm39) P312S probably benign Het
Snapc1 T A 12: 74,011,454 (GRCm39) M40K probably benign Het
Sptbn2 T G 19: 4,796,000 (GRCm39) Y1726* probably null Het
Syne2 T C 12: 76,033,881 (GRCm39) I3710T probably damaging Het
Tdrd9 G A 12: 112,006,868 (GRCm39) V911M probably damaging Het
Tex9 A T 9: 72,388,036 (GRCm39) D134E possibly damaging Het
Ttc41 G T 10: 86,611,821 (GRCm39) C1063F possibly damaging Het
Usp38 C A 8: 81,716,647 (GRCm39) A496S possibly damaging Het
Vmn2r13 T A 5: 109,304,568 (GRCm39) Y621F probably damaging Het
Vmn2r67 T A 7: 84,785,834 (GRCm39) M724L probably benign Het
Other mutations in Or11g2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02136:Or11g2 APN 14 50,855,708 (GRCm39) missense possibly damaging 0.86
IGL02165:Or11g2 APN 14 50,856,468 (GRCm39) missense probably damaging 1.00
IGL02207:Or11g2 APN 14 50,856,015 (GRCm39) missense probably damaging 1.00
IGL02556:Or11g2 APN 14 50,856,185 (GRCm39) missense probably benign 0.01
IGL02710:Or11g2 APN 14 50,856,255 (GRCm39) missense probably benign 0.02
R0127:Or11g2 UTSW 14 50,855,789 (GRCm39) missense probably benign
R0389:Or11g2 UTSW 14 50,856,036 (GRCm39) missense probably damaging 1.00
R0603:Or11g2 UTSW 14 50,855,967 (GRCm39) missense probably damaging 1.00
R0927:Or11g2 UTSW 14 50,856,044 (GRCm39) missense possibly damaging 0.47
R1477:Or11g2 UTSW 14 50,856,170 (GRCm39) missense probably damaging 0.98
R1705:Or11g2 UTSW 14 50,856,579 (GRCm39) missense probably benign 0.01
R1800:Or11g2 UTSW 14 50,856,143 (GRCm39) missense probably benign 0.01
R1898:Or11g2 UTSW 14 50,856,231 (GRCm39) missense probably damaging 1.00
R2244:Or11g2 UTSW 14 50,856,114 (GRCm39) missense probably damaging 1.00
R4731:Or11g2 UTSW 14 50,856,026 (GRCm39) missense probably benign 0.11
R4732:Or11g2 UTSW 14 50,856,026 (GRCm39) missense probably benign 0.11
R4733:Or11g2 UTSW 14 50,856,026 (GRCm39) missense probably benign 0.11
R4801:Or11g2 UTSW 14 50,856,479 (GRCm39) missense probably benign 0.01
R4802:Or11g2 UTSW 14 50,856,479 (GRCm39) missense probably benign 0.01
R5068:Or11g2 UTSW 14 50,856,197 (GRCm39) missense probably damaging 1.00
R5069:Or11g2 UTSW 14 50,856,197 (GRCm39) missense probably damaging 1.00
R5070:Or11g2 UTSW 14 50,856,197 (GRCm39) missense probably damaging 1.00
R5070:Or11g2 UTSW 14 50,855,931 (GRCm39) missense probably benign 0.11
R5195:Or11g2 UTSW 14 50,856,243 (GRCm39) missense probably damaging 1.00
R6058:Or11g2 UTSW 14 50,856,158 (GRCm39) missense probably benign 0.03
R8246:Or11g2 UTSW 14 50,855,841 (GRCm39) missense probably benign
R8275:Or11g2 UTSW 14 50,855,868 (GRCm39) missense probably damaging 1.00
R9292:Or11g2 UTSW 14 50,856,513 (GRCm39) missense possibly damaging 0.94
Posted On 2013-11-11