Incidental Mutation 'IGL01433:Lax1'
ID 84243
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lax1
Ensembl Gene ENSMUSG00000051998
Gene Name lymphocyte transmembrane adaptor 1
Synonyms E430019B13Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.048) question?
Stock # IGL01433
Quality Score
Status
Chromosome 1
Chromosomal Location 133606829-133617846 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 133608137 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Methionine at position 201 (I201M)
Ref Sequence ENSEMBL: ENSMUSP00000131126 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000169295] [ENSMUST00000189524]
AlphaFold Q8BHB3
Predicted Effect probably benign
Transcript: ENSMUST00000169295
AA Change: I201M

PolyPhen 2 Score 0.087 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000131126
Gene: ENSMUSG00000051998
AA Change: I201M

DomainStartEndE-ValueType
Pfam:LAX 27 378 2.4e-172 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000189524
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous null mice exhibit spontaneous germinal center formation and increased IgG1, IgG2a, and IgE levels. T and B cells are hyperresponsive upon engagement of T or B AgRs. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actrt3 C T 3: 30,652,188 (GRCm39) G302D probably damaging Het
Adam19 T C 11: 46,003,610 (GRCm39) L146P probably damaging Het
Adcy8 T A 15: 64,609,263 (GRCm39) Y852F possibly damaging Het
Arfgef1 T C 1: 10,223,657 (GRCm39) T1520A probably damaging Het
Atp8b1 C T 18: 64,706,590 (GRCm39) V199I probably benign Het
Avl9 A G 6: 56,730,382 (GRCm39) D575G probably damaging Het
Bcam C A 7: 19,494,107 (GRCm39) V395L possibly damaging Het
Bltp1 T G 3: 36,941,919 (GRCm39) S241R probably damaging Het
Ccdc198 G T 14: 49,473,341 (GRCm39) T128K probably benign Het
Cgn T A 3: 94,686,769 (GRCm39) N178Y probably damaging Het
D5Ertd579e A T 5: 36,776,098 (GRCm39) D168E probably damaging Het
Dnah17 G T 11: 117,940,760 (GRCm39) T3288K probably damaging Het
Ednrb A T 14: 104,080,626 (GRCm39) I96N probably damaging Het
Gdpd3 A G 7: 126,370,356 (GRCm39) I264V possibly damaging Het
Itih4 T C 14: 30,617,405 (GRCm39) V575A probably benign Het
Jhy G A 9: 40,828,512 (GRCm39) R465C possibly damaging Het
Kcna4 C T 2: 107,127,078 (GRCm39) S604F probably damaging Het
Kcnj6 A G 16: 94,633,814 (GRCm39) V99A probably benign Het
Kdm2a A G 19: 4,392,888 (GRCm39) I489T possibly damaging Het
Kif13a A G 13: 46,926,384 (GRCm39) S241P probably damaging Het
Lzic T A 4: 149,572,604 (GRCm39) S65T probably benign Het
Marchf9 T C 10: 126,892,562 (GRCm39) T309A probably benign Het
Ndufc1 T C 3: 51,314,797 (GRCm39) K70E possibly damaging Het
Optn T C 2: 5,031,955 (GRCm39) K504R probably benign Het
Or51q1 A T 7: 103,628,539 (GRCm39) I53F probably damaging Het
Pagr1a A G 7: 126,614,647 (GRCm39) probably benign Het
Pold1 G A 7: 44,192,656 (GRCm39) probably benign Het
Ptprq A G 10: 107,412,741 (GRCm39) I1786T probably damaging Het
Rgs20 T C 1: 5,140,300 (GRCm39) D34G possibly damaging Het
Rnps1 T C 17: 24,643,519 (GRCm39) probably null Het
Rpgrip1 T C 14: 52,363,834 (GRCm39) V261A probably damaging Het
Sfxn1 A G 13: 54,247,935 (GRCm39) N220S probably benign Het
Slc35f1 T A 10: 52,949,542 (GRCm39) probably benign Het
Slc5a4b T C 10: 75,906,329 (GRCm39) probably benign Het
Snx19 A G 9: 30,340,067 (GRCm39) I402V possibly damaging Het
Spaca6 T C 17: 18,051,429 (GRCm39) V35A probably benign Het
Taar2 A G 10: 23,816,657 (GRCm39) T66A probably benign Het
Tanc2 C T 11: 105,701,348 (GRCm39) H288Y possibly damaging Het
Tbc1d31 A G 15: 57,804,164 (GRCm39) Q393R probably benign Het
Trpm1 A G 7: 63,854,276 (GRCm39) Y133C probably damaging Het
Vmn2r105 T C 17: 20,448,817 (GRCm39) D120G probably benign Het
Vmn2r56 C A 7: 12,449,541 (GRCm39) M232I probably benign Het
Vps35l A G 7: 118,373,274 (GRCm39) probably null Het
Zfp251 C T 15: 76,738,755 (GRCm39) V113I probably benign Het
Other mutations in Lax1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01568:Lax1 APN 1 133,608,038 (GRCm39) missense probably benign 0.00
IGL02352:Lax1 APN 1 133,608,208 (GRCm39) missense possibly damaging 0.95
IGL02359:Lax1 APN 1 133,608,208 (GRCm39) missense possibly damaging 0.95
IGL02449:Lax1 APN 1 133,607,874 (GRCm39) missense probably damaging 0.98
yon UTSW 1 133,610,774 (GRCm39) missense probably benign 0.20
R0391:Lax1 UTSW 1 133,607,804 (GRCm39) missense probably benign 0.24
R1728:Lax1 UTSW 1 133,611,372 (GRCm39) missense probably damaging 1.00
R1728:Lax1 UTSW 1 133,607,716 (GRCm39) missense probably benign
R1728:Lax1 UTSW 1 133,608,307 (GRCm39) missense probably benign 0.00
R1729:Lax1 UTSW 1 133,611,372 (GRCm39) missense probably damaging 1.00
R1729:Lax1 UTSW 1 133,607,716 (GRCm39) missense probably benign
R1729:Lax1 UTSW 1 133,608,307 (GRCm39) missense probably benign 0.00
R1730:Lax1 UTSW 1 133,611,372 (GRCm39) missense probably damaging 1.00
R1730:Lax1 UTSW 1 133,607,716 (GRCm39) missense probably benign
R1730:Lax1 UTSW 1 133,608,307 (GRCm39) missense probably benign 0.00
R1739:Lax1 UTSW 1 133,611,372 (GRCm39) missense probably damaging 1.00
R1739:Lax1 UTSW 1 133,607,716 (GRCm39) missense probably benign
R1739:Lax1 UTSW 1 133,608,307 (GRCm39) missense probably benign 0.00
R1762:Lax1 UTSW 1 133,607,716 (GRCm39) missense probably benign
R1762:Lax1 UTSW 1 133,608,307 (GRCm39) missense probably benign 0.00
R1762:Lax1 UTSW 1 133,611,372 (GRCm39) missense probably damaging 1.00
R1783:Lax1 UTSW 1 133,611,372 (GRCm39) missense probably damaging 1.00
R1783:Lax1 UTSW 1 133,608,307 (GRCm39) missense probably benign 0.00
R1783:Lax1 UTSW 1 133,607,716 (GRCm39) missense probably benign
R1784:Lax1 UTSW 1 133,611,372 (GRCm39) missense probably damaging 1.00
R1784:Lax1 UTSW 1 133,608,307 (GRCm39) missense probably benign 0.00
R1784:Lax1 UTSW 1 133,607,716 (GRCm39) missense probably benign
R1785:Lax1 UTSW 1 133,611,372 (GRCm39) missense probably damaging 1.00
R1785:Lax1 UTSW 1 133,608,307 (GRCm39) missense probably benign 0.00
R1785:Lax1 UTSW 1 133,607,716 (GRCm39) missense probably benign
R2254:Lax1 UTSW 1 133,607,971 (GRCm39) missense probably damaging 0.99
R2906:Lax1 UTSW 1 133,616,643 (GRCm39) start codon destroyed probably null 0.53
R2912:Lax1 UTSW 1 133,611,791 (GRCm39) missense possibly damaging 0.77
R4022:Lax1 UTSW 1 133,610,774 (GRCm39) missense probably benign 0.20
R5234:Lax1 UTSW 1 133,608,321 (GRCm39) missense probably benign 0.02
R5686:Lax1 UTSW 1 133,607,914 (GRCm39) missense probably damaging 1.00
R5695:Lax1 UTSW 1 133,608,316 (GRCm39) missense probably damaging 1.00
R6003:Lax1 UTSW 1 133,611,834 (GRCm39) missense probably benign 0.24
R6362:Lax1 UTSW 1 133,608,334 (GRCm39) missense possibly damaging 0.92
R6493:Lax1 UTSW 1 133,607,530 (GRCm39) missense probably benign
R6494:Lax1 UTSW 1 133,608,186 (GRCm39) missense probably damaging 0.99
R6932:Lax1 UTSW 1 133,607,896 (GRCm39) missense probably benign 0.39
R7938:Lax1 UTSW 1 133,607,896 (GRCm39) missense probably benign 0.00
R8054:Lax1 UTSW 1 133,611,345 (GRCm39) missense probably benign 0.00
R8476:Lax1 UTSW 1 133,611,326 (GRCm39) missense probably benign 0.00
R9201:Lax1 UTSW 1 133,608,205 (GRCm39) missense possibly damaging 0.95
R9287:Lax1 UTSW 1 133,607,931 (GRCm39) missense probably benign 0.00
R9416:Lax1 UTSW 1 133,611,752 (GRCm39) missense probably benign 0.12
Posted On 2013-11-11