Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01433:Lzic'

84254

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Lzic

Ensembl Gene

ENSMUSG00000028990

Gene Name

leucine zipper and CTNNBIP1 domain containing

Synonyms

1810030J04Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.152) question?

Stock #

IGL01433

Quality Score

Status

Chromosome

Chromosomal Location

149569686-149581125 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 149572604 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Threonine at position 65 (S65T)

Ref Sequence

ENSEMBL: ENSMUSP00000030842 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000030842] [ENSMUST00000030845] [ENSMUST00000105693] [ENSMUST00000119921] [ENSMUST00000124413] [ENSMUST00000126896] [ENSMUST00000141293] [ENSMUST00000210722] [ENSMUST00000229840]

AlphaFold

Q8K3C3

Predicted Effect

probably benign
Transcript: ENSMUST00000030842
AA Change: S65T

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

SMART Domains

Protein: ENSMUSP00000030842
Gene: ENSMUSG00000028990
AA Change: S65T

Domain	Start	End	E-Value	Type
coiled coil region	2	63	N/A	INTRINSIC
Pfam:ICAT	113	188	5.7e-36	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000030845

SMART Domains

Protein: ENSMUSP00000030845
Gene: ENSMUSG00000028992

Domain	Start	End	E-Value	Type
Pfam:CTP_transf_2	12	230	2.5e-34	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000105693

SMART Domains

Protein: ENSMUSP00000101318
Gene: ENSMUSG00000028992

Domain	Start	End	E-Value	Type
Pfam:CTP_transf_like	12	230	9.5e-32	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000119921

SMART Domains

Protein: ENSMUSP00000113156
Gene: ENSMUSG00000028992

Domain	Start	End	E-Value	Type
Pfam:CTP_transf_2	12	140	9.8e-23	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000122947

Predicted Effect

probably benign
Transcript: ENSMUST00000124413

SMART Domains

Protein: ENSMUSP00000116150
Gene: ENSMUSG00000028990

Domain	Start	End	E-Value	Type
SCOP:d1lxa__	11	56	7e-4	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000126896

Predicted Effect

probably benign
Transcript: ENSMUST00000141293
AA Change: S65T

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000119294
Gene: ENSMUSG00000028990
AA Change: S65T

Domain	Start	End	E-Value	Type
SCOP:d1lxa__	11	61	1e-3	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000146427

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000138464

Predicted Effect

probably benign
Transcript: ENSMUST00000210722

Predicted Effect

probably benign
Transcript: ENSMUST00000229840

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Actrt3	C	T	3: 30,652,188 (GRCm39)	G302D	probably damaging	Het
Adam19	T	C	11: 46,003,610 (GRCm39)	L146P	probably damaging	Het
Adcy8	T	A	15: 64,609,263 (GRCm39)	Y852F	possibly damaging	Het
Arfgef1	T	C	1: 10,223,657 (GRCm39)	T1520A	probably damaging	Het
Atp8b1	C	T	18: 64,706,590 (GRCm39)	V199I	probably benign	Het
Avl9	A	G	6: 56,730,382 (GRCm39)	D575G	probably damaging	Het
Bcam	C	A	7: 19,494,107 (GRCm39)	V395L	possibly damaging	Het
Bltp1	T	G	3: 36,941,919 (GRCm39)	S241R	probably damaging	Het
Ccdc198	G	T	14: 49,473,341 (GRCm39)	T128K	probably benign	Het
Cgn	T	A	3: 94,686,769 (GRCm39)	N178Y	probably damaging	Het
D5Ertd579e	A	T	5: 36,776,098 (GRCm39)	D168E	probably damaging	Het
Dnah17	G	T	11: 117,940,760 (GRCm39)	T3288K	probably damaging	Het
Ednrb	A	T	14: 104,080,626 (GRCm39)	I96N	probably damaging	Het
Gdpd3	A	G	7: 126,370,356 (GRCm39)	I264V	possibly damaging	Het
Itih4	T	C	14: 30,617,405 (GRCm39)	V575A	probably benign	Het
Jhy	G	A	9: 40,828,512 (GRCm39)	R465C	possibly damaging	Het
Kcna4	C	T	2: 107,127,078 (GRCm39)	S604F	probably damaging	Het
Kcnj6	A	G	16: 94,633,814 (GRCm39)	V99A	probably benign	Het
Kdm2a	A	G	19: 4,392,888 (GRCm39)	I489T	possibly damaging	Het
Kif13a	A	G	13: 46,926,384 (GRCm39)	S241P	probably damaging	Het
Lax1	T	C	1: 133,608,137 (GRCm39)	I201M	probably benign	Het
Marchf9	T	C	10: 126,892,562 (GRCm39)	T309A	probably benign	Het
Ndufc1	T	C	3: 51,314,797 (GRCm39)	K70E	possibly damaging	Het
Optn	T	C	2: 5,031,955 (GRCm39)	K504R	probably benign	Het
Or51q1	A	T	7: 103,628,539 (GRCm39)	I53F	probably damaging	Het
Pagr1a	A	G	7: 126,614,647 (GRCm39)		probably benign	Het
Pold1	G	A	7: 44,192,656 (GRCm39)		probably benign	Het
Ptprq	A	G	10: 107,412,741 (GRCm39)	I1786T	probably damaging	Het
Rgs20	T	C	1: 5,140,300 (GRCm39)	D34G	possibly damaging	Het
Rnps1	T	C	17: 24,643,519 (GRCm39)		probably null	Het
Rpgrip1	T	C	14: 52,363,834 (GRCm39)	V261A	probably damaging	Het
Sfxn1	A	G	13: 54,247,935 (GRCm39)	N220S	probably benign	Het
Slc35f1	T	A	10: 52,949,542 (GRCm39)		probably benign	Het
Slc5a4b	T	C	10: 75,906,329 (GRCm39)		probably benign	Het
Snx19	A	G	9: 30,340,067 (GRCm39)	I402V	possibly damaging	Het
Spaca6	T	C	17: 18,051,429 (GRCm39)	V35A	probably benign	Het
Taar2	A	G	10: 23,816,657 (GRCm39)	T66A	probably benign	Het
Tanc2	C	T	11: 105,701,348 (GRCm39)	H288Y	possibly damaging	Het
Tbc1d31	A	G	15: 57,804,164 (GRCm39)	Q393R	probably benign	Het
Trpm1	A	G	7: 63,854,276 (GRCm39)	Y133C	probably damaging	Het
Vmn2r105	T	C	17: 20,448,817 (GRCm39)	D120G	probably benign	Het
Vmn2r56	C	A	7: 12,449,541 (GRCm39)	M232I	probably benign	Het
Vps35l	A	G	7: 118,373,274 (GRCm39)		probably null	Het
Zfp251	C	T	15: 76,738,755 (GRCm39)	V113I	probably benign	Het

Other mutations in Lzic

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00886:Lzic	APN	4	149,577,753 (GRCm39)	critical splice donor site	probably null
IGL02480:Lzic	APN	4	149,571,260 (GRCm39)	missense	probably damaging	1.00
R0097:Lzic	UTSW	4	149,572,533 (GRCm39)	missense	probably damaging	1.00
R0097:Lzic	UTSW	4	149,572,533 (GRCm39)	missense	probably damaging	1.00
R1345:Lzic	UTSW	4	149,571,308 (GRCm39)	missense	probably damaging	1.00
R2162:Lzic	UTSW	4	149,573,185 (GRCm39)	missense	probably null	0.01
R3831:Lzic	UTSW	4	149,573,185 (GRCm39)	missense	probably null	0.01
R4589:Lzic	UTSW	4	149,572,561 (GRCm39)	missense	probably damaging	0.98
R4929:Lzic	UTSW	4	149,572,585 (GRCm39)	splice site	probably null
R5837:Lzic	UTSW	4	149,570,457 (GRCm39)	critical splice donor site	probably null
R7126:Lzic	UTSW	4	149,573,132 (GRCm39)	missense	probably damaging	0.99
R8154:Lzic	UTSW	4	149,573,141 (GRCm39)	missense	probably damaging	1.00
R8316:Lzic	UTSW	4	149,572,527 (GRCm39)	missense	probably benign	0.03
R9632:Lzic	UTSW	4	149,573,141 (GRCm39)	missense	probably damaging	1.00
R9710:Lzic	UTSW	4	149,573,141 (GRCm39)	missense	probably damaging	1.00

Posted On

2013-11-11