Incidental Mutation 'IGL01443:Cdk12'
ID 84324
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cdk12
Ensembl Gene ENSMUSG00000003119
Gene Name cyclin dependent kinase 12
Synonyms Crkrs, Crk7, D11Ertd752e, 1810022J16Rik
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # IGL01443
Quality Score
Status
Chromosome 11
Chromosomal Location 98093885-98169330 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 98136295 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glutamic Acid at position 1183 (V1183E)
Ref Sequence ENSEMBL: ENSMUSP00000103163 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000003203] [ENSMUST00000107538] [ENSMUST00000107539]
AlphaFold Q14AX6
Predicted Effect unknown
Transcript: ENSMUST00000003203
AA Change: V1183E
SMART Domains Protein: ENSMUSP00000003203
Gene: ENSMUSG00000003119
AA Change: V1183E

DomainStartEndE-ValueType
low complexity region 8 32 N/A INTRINSIC
low complexity region 40 51 N/A INTRINSIC
low complexity region 74 92 N/A INTRINSIC
low complexity region 103 123 N/A INTRINSIC
low complexity region 124 135 N/A INTRINSIC
low complexity region 166 177 N/A INTRINSIC
low complexity region 214 227 N/A INTRINSIC
low complexity region 286 384 N/A INTRINSIC
low complexity region 511 568 N/A INTRINSIC
low complexity region 623 633 N/A INTRINSIC
low complexity region 666 684 N/A INTRINSIC
S_TKc 723 1016 1.49e-95 SMART
Predicted Effect unknown
Transcript: ENSMUST00000107538
AA Change: V1183E
SMART Domains Protein: ENSMUSP00000103162
Gene: ENSMUSG00000003119
AA Change: V1183E

DomainStartEndE-ValueType
low complexity region 8 32 N/A INTRINSIC
low complexity region 40 51 N/A INTRINSIC
low complexity region 74 92 N/A INTRINSIC
low complexity region 103 123 N/A INTRINSIC
low complexity region 124 135 N/A INTRINSIC
low complexity region 166 177 N/A INTRINSIC
low complexity region 214 227 N/A INTRINSIC
low complexity region 286 384 N/A INTRINSIC
low complexity region 511 568 N/A INTRINSIC
low complexity region 623 633 N/A INTRINSIC
low complexity region 666 684 N/A INTRINSIC
S_TKc 723 1016 1.49e-95 SMART
low complexity region 1252 1276 N/A INTRINSIC
low complexity region 1467 1483 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000107539
AA Change: V1183E
SMART Domains Protein: ENSMUSP00000103163
Gene: ENSMUSG00000003119
AA Change: V1183E

DomainStartEndE-ValueType
low complexity region 8 32 N/A INTRINSIC
low complexity region 40 51 N/A INTRINSIC
low complexity region 74 92 N/A INTRINSIC
low complexity region 103 123 N/A INTRINSIC
low complexity region 124 135 N/A INTRINSIC
low complexity region 166 177 N/A INTRINSIC
low complexity region 214 227 N/A INTRINSIC
low complexity region 286 384 N/A INTRINSIC
low complexity region 511 568 N/A INTRINSIC
low complexity region 623 633 N/A INTRINSIC
low complexity region 666 684 N/A INTRINSIC
S_TKc 723 1016 1.49e-95 SMART
low complexity region 1253 1267 N/A INTRINSIC
low complexity region 1458 1474 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147441
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit lethality between implantation and E6.5 with decreased proliferation and increased apoptosis in the inner cell mass. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts2 A G 11: 50,694,690 (GRCm39) E1159G possibly damaging Het
Adgrl3 A G 5: 81,613,134 (GRCm39) Y189C probably damaging Het
AW554918 G A 18: 25,478,012 (GRCm39) G446R probably damaging Het
Baiap3 A G 17: 25,464,121 (GRCm39) F884S possibly damaging Het
Cd101 T C 3: 100,910,887 (GRCm39) T924A probably benign Het
Clcc1 T C 3: 108,578,219 (GRCm39) M240T probably benign Het
Dnmbp C A 19: 43,891,309 (GRCm39) A153S probably damaging Het
Dus4l T C 12: 31,702,409 (GRCm39) probably benign Het
Dyrk1a A G 16: 94,485,943 (GRCm39) E430G probably benign Het
Erc1 T C 6: 119,801,432 (GRCm39) K195R probably damaging Het
Evpl T C 11: 116,113,280 (GRCm39) E1470G probably damaging Het
Extl3 A T 14: 65,314,919 (GRCm39) S88T probably damaging Het
Fam135b A T 15: 71,335,213 (GRCm39) H660Q probably benign Het
Fat1 G A 8: 45,493,613 (GRCm39) G3920S probably damaging Het
Fbxo38 A G 18: 62,666,741 (GRCm39) V144A probably damaging Het
Grwd1 C T 7: 45,479,834 (GRCm39) probably null Het
Hdlbp T C 1: 93,358,796 (GRCm39) T252A probably damaging Het
Igkv3-1 A G 6: 70,681,088 (GRCm39) S96G possibly damaging Het
Igkv4-68 G T 6: 69,281,921 (GRCm39) F83L probably damaging Het
Klhl31 T C 9: 77,557,542 (GRCm39) V86A possibly damaging Het
Lypd3 G A 7: 24,336,063 (GRCm39) G17R probably benign Het
Manba T A 3: 135,250,589 (GRCm39) D405E probably damaging Het
Map3k19 A G 1: 127,766,244 (GRCm39) S227P probably benign Het
Nras T A 3: 102,969,751 (GRCm39) C118S probably benign Het
Or52n20 A G 7: 104,320,278 (GRCm39) D123G probably damaging Het
Pde8a T C 7: 80,973,929 (GRCm39) F629L probably damaging Het
Phtf2 A G 5: 20,987,265 (GRCm39) probably benign Het
Pik3c2a A T 7: 116,017,429 (GRCm39) F109L probably benign Het
Plod3 G A 5: 137,019,075 (GRCm39) R320H probably benign Het
Ppib T C 9: 65,972,879 (GRCm39) F152L probably damaging Het
Rbm19 T C 5: 120,281,503 (GRCm39) probably benign Het
Rgs12 T A 5: 35,132,563 (GRCm39) S628R probably benign Het
Ripk1 A G 13: 34,199,251 (GRCm39) D201G probably damaging Het
Speer4c2 A G 5: 15,857,642 (GRCm39) *212Q probably null Het
St14 G T 9: 31,011,489 (GRCm39) S434* probably null Het
Tbc1d9 A G 8: 83,966,560 (GRCm39) D387G probably damaging Het
Trio A G 15: 27,838,861 (GRCm39) probably benign Het
Ttn G A 2: 76,544,215 (GRCm39) R32924C probably damaging Het
Vmn1r181 T C 7: 23,684,006 (GRCm39) V157A possibly damaging Het
Zfp473 C T 7: 44,388,987 (GRCm39) D45N probably damaging Het
Other mutations in Cdk12
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00324:Cdk12 APN 11 98,136,214 (GRCm39) missense unknown
IGL00718:Cdk12 APN 11 98,140,502 (GRCm39) intron probably benign
IGL00850:Cdk12 APN 11 98,113,491 (GRCm39) missense unknown
IGL01299:Cdk12 APN 11 98,101,272 (GRCm39) missense unknown
IGL01597:Cdk12 APN 11 98,141,090 (GRCm39) unclassified probably benign
capsized UTSW 11 98,132,611 (GRCm39) missense unknown
Listing UTSW 11 98,115,293 (GRCm39) nonsense probably null
Torpedoed UTSW 11 98,111,928 (GRCm39) missense unknown
R0124:Cdk12 UTSW 11 98,102,073 (GRCm39) splice site probably benign
R0157:Cdk12 UTSW 11 98,140,602 (GRCm39) unclassified probably benign
R0190:Cdk12 UTSW 11 98,132,657 (GRCm39) critical splice donor site probably null
R0230:Cdk12 UTSW 11 98,094,817 (GRCm39) missense probably damaging 1.00
R0467:Cdk12 UTSW 11 98,094,405 (GRCm39) missense probably damaging 0.99
R0577:Cdk12 UTSW 11 98,094,332 (GRCm39) missense probably damaging 0.99
R0671:Cdk12 UTSW 11 98,120,935 (GRCm39) splice site probably benign
R0834:Cdk12 UTSW 11 98,095,211 (GRCm39) missense probably benign 0.23
R1129:Cdk12 UTSW 11 98,136,201 (GRCm39) missense unknown
R1337:Cdk12 UTSW 11 98,136,497 (GRCm39) critical splice donor site probably null
R1344:Cdk12 UTSW 11 98,132,611 (GRCm39) missense unknown
R1418:Cdk12 UTSW 11 98,132,611 (GRCm39) missense unknown
R1729:Cdk12 UTSW 11 98,140,796 (GRCm39) unclassified probably benign
R1756:Cdk12 UTSW 11 98,132,587 (GRCm39) nonsense probably null
R1784:Cdk12 UTSW 11 98,140,796 (GRCm39) unclassified probably benign
R1807:Cdk12 UTSW 11 98,101,203 (GRCm39) missense unknown
R1956:Cdk12 UTSW 11 98,110,042 (GRCm39) missense probably benign 0.23
R1966:Cdk12 UTSW 11 98,094,916 (GRCm39) nonsense probably null
R2202:Cdk12 UTSW 11 98,101,464 (GRCm39) missense unknown
R2422:Cdk12 UTSW 11 98,109,900 (GRCm39) missense probably benign 0.23
R2570:Cdk12 UTSW 11 98,094,618 (GRCm39) missense possibly damaging 0.94
R4574:Cdk12 UTSW 11 98,111,814 (GRCm39) intron probably benign
R4614:Cdk12 UTSW 11 98,140,603 (GRCm39) unclassified probably benign
R4882:Cdk12 UTSW 11 98,101,272 (GRCm39) missense unknown
R4921:Cdk12 UTSW 11 98,113,513 (GRCm39) missense unknown
R5151:Cdk12 UTSW 11 98,140,749 (GRCm39) unclassified probably benign
R5252:Cdk12 UTSW 11 98,134,335 (GRCm39) missense unknown
R5348:Cdk12 UTSW 11 98,095,118 (GRCm39) missense probably benign 0.23
R5620:Cdk12 UTSW 11 98,101,809 (GRCm39) missense unknown
R5779:Cdk12 UTSW 11 98,109,900 (GRCm39) missense probably benign 0.23
R6085:Cdk12 UTSW 11 98,134,255 (GRCm39) missense unknown
R6293:Cdk12 UTSW 11 98,115,379 (GRCm39) missense unknown
R6371:Cdk12 UTSW 11 98,136,114 (GRCm39) missense unknown
R6438:Cdk12 UTSW 11 98,115,293 (GRCm39) nonsense probably null
R6765:Cdk12 UTSW 11 98,115,355 (GRCm39) missense unknown
R6958:Cdk12 UTSW 11 98,132,525 (GRCm39) missense unknown
R7205:Cdk12 UTSW 11 98,115,451 (GRCm39) missense unknown
R7307:Cdk12 UTSW 11 98,140,626 (GRCm39) nonsense probably null
R7361:Cdk12 UTSW 11 98,101,294 (GRCm39) nonsense probably null
R7365:Cdk12 UTSW 11 98,111,910 (GRCm39) missense unknown
R7447:Cdk12 UTSW 11 98,136,106 (GRCm39) missense unknown
R7514:Cdk12 UTSW 11 98,113,484 (GRCm39) missense unknown
R7831:Cdk12 UTSW 11 98,140,653 (GRCm39) missense unknown
R7877:Cdk12 UTSW 11 98,131,661 (GRCm39) missense unknown
R7975:Cdk12 UTSW 11 98,111,928 (GRCm39) missense unknown
R8507:Cdk12 UTSW 11 98,141,111 (GRCm39) missense unknown
R8558:Cdk12 UTSW 11 98,101,915 (GRCm39) missense unknown
R8693:Cdk12 UTSW 11 98,141,133 (GRCm39) missense unknown
R9250:Cdk12 UTSW 11 98,101,398 (GRCm39) missense probably benign 0.23
R9517:Cdk12 UTSW 11 98,109,910 (GRCm39) missense unknown
R9562:Cdk12 UTSW 11 98,140,628 (GRCm39) missense unknown
R9565:Cdk12 UTSW 11 98,140,628 (GRCm39) missense unknown
R9792:Cdk12 UTSW 11 98,102,051 (GRCm39) missense unknown
R9793:Cdk12 UTSW 11 98,102,051 (GRCm39) missense unknown
R9795:Cdk12 UTSW 11 98,102,051 (GRCm39) missense unknown
Z1176:Cdk12 UTSW 11 98,094,767 (GRCm39) nonsense probably null
Posted On 2013-11-11