Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01443:Dus4l'

84338

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Dus4l

Ensembl Gene

ENSMUSG00000020648

Gene Name

dihydrouridine synthase 4 like

Synonyms

2700089B10Rik, 2310069P03Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.160) question?

Stock #

IGL01443

Quality Score

Status

Chromosome

Chromosomal Location

31690049-31704825 bp(-) (GRCm39)

Type of Mutation

unclassified

DNA Base Change (assembly)

T to C at 31702409 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000044797 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000020977] [ENSMUST00000036862]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000020977

SMART Domains

Protein: ENSMUSP00000020977
Gene: ENSMUSG00000020648

Domain	Start	End	E-Value	Type
Pfam:Dus	30	312	3.3e-76	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000036862

SMART Domains

Protein: ENSMUSP00000044797
Gene: ENSMUSG00000035933

Domain	Start	End	E-Value	Type
low complexity region	9	23	N/A	INTRINSIC
Pfam:COG5	35	158	3.8e-37	PFAM
Pfam:Vps51	37	120	1.8e-12	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000219098

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000219855

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamts2	A	G	11: 50,694,690 (GRCm39)	E1159G	possibly damaging	Het
Adgrl3	A	G	5: 81,613,134 (GRCm39)	Y189C	probably damaging	Het
AW554918	G	A	18: 25,478,012 (GRCm39)	G446R	probably damaging	Het
Baiap3	A	G	17: 25,464,121 (GRCm39)	F884S	possibly damaging	Het
Cd101	T	C	3: 100,910,887 (GRCm39)	T924A	probably benign	Het
Cdk12	T	A	11: 98,136,295 (GRCm39)	V1183E	unknown	Het
Clcc1	T	C	3: 108,578,219 (GRCm39)	M240T	probably benign	Het
Dnmbp	C	A	19: 43,891,309 (GRCm39)	A153S	probably damaging	Het
Dyrk1a	A	G	16: 94,485,943 (GRCm39)	E430G	probably benign	Het
Erc1	T	C	6: 119,801,432 (GRCm39)	K195R	probably damaging	Het
Evpl	T	C	11: 116,113,280 (GRCm39)	E1470G	probably damaging	Het
Extl3	A	T	14: 65,314,919 (GRCm39)	S88T	probably damaging	Het
Fam135b	A	T	15: 71,335,213 (GRCm39)	H660Q	probably benign	Het
Fat1	G	A	8: 45,493,613 (GRCm39)	G3920S	probably damaging	Het
Fbxo38	A	G	18: 62,666,741 (GRCm39)	V144A	probably damaging	Het
Grwd1	C	T	7: 45,479,834 (GRCm39)		probably null	Het
Hdlbp	T	C	1: 93,358,796 (GRCm39)	T252A	probably damaging	Het
Igkv3-1	A	G	6: 70,681,088 (GRCm39)	S96G	possibly damaging	Het
Igkv4-68	G	T	6: 69,281,921 (GRCm39)	F83L	probably damaging	Het
Klhl31	T	C	9: 77,557,542 (GRCm39)	V86A	possibly damaging	Het
Lypd3	G	A	7: 24,336,063 (GRCm39)	G17R	probably benign	Het
Manba	T	A	3: 135,250,589 (GRCm39)	D405E	probably damaging	Het
Map3k19	A	G	1: 127,766,244 (GRCm39)	S227P	probably benign	Het
Nras	T	A	3: 102,969,751 (GRCm39)	C118S	probably benign	Het
Or52n20	A	G	7: 104,320,278 (GRCm39)	D123G	probably damaging	Het
Pde8a	T	C	7: 80,973,929 (GRCm39)	F629L	probably damaging	Het
Phtf2	A	G	5: 20,987,265 (GRCm39)		probably benign	Het
Pik3c2a	A	T	7: 116,017,429 (GRCm39)	F109L	probably benign	Het
Plod3	G	A	5: 137,019,075 (GRCm39)	R320H	probably benign	Het
Ppib	T	C	9: 65,972,879 (GRCm39)	F152L	probably damaging	Het
Rbm19	T	C	5: 120,281,503 (GRCm39)		probably benign	Het
Rgs12	T	A	5: 35,132,563 (GRCm39)	S628R	probably benign	Het
Ripk1	A	G	13: 34,199,251 (GRCm39)	D201G	probably damaging	Het
Speer4c2	A	G	5: 15,857,642 (GRCm39)	*212Q	probably null	Het
St14	G	T	9: 31,011,489 (GRCm39)	S434*	probably null	Het
Tbc1d9	A	G	8: 83,966,560 (GRCm39)	D387G	probably damaging	Het
Trio	A	G	15: 27,838,861 (GRCm39)		probably benign	Het
Ttn	G	A	2: 76,544,215 (GRCm39)	R32924C	probably damaging	Het
Vmn1r181	T	C	7: 23,684,006 (GRCm39)	V157A	possibly damaging	Het
Zfp473	C	T	7: 44,388,987 (GRCm39)	D45N	probably damaging	Het

Other mutations in Dus4l

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00429:Dus4l	APN	12	31,691,668 (GRCm39)	missense	probably benign	0.27
IGL01299:Dus4l	APN	12	31,690,823 (GRCm39)	missense	probably benign
IGL01796:Dus4l	APN	12	31,692,794 (GRCm39)	missense	probably benign	0.01
IGL02234:Dus4l	APN	12	31,691,495 (GRCm39)	splice site	probably benign
IGL02385:Dus4l	APN	12	31,690,674 (GRCm39)	utr 3 prime	probably benign
R0483:Dus4l	UTSW	12	31,691,656 (GRCm39)	missense	possibly damaging	0.91
R1432:Dus4l	UTSW	12	31,698,770 (GRCm39)	missense	probably benign	0.03
R1514:Dus4l	UTSW	12	31,690,938 (GRCm39)	missense	probably damaging	1.00
R1880:Dus4l	UTSW	12	31,690,869 (GRCm39)	missense	probably benign	0.00
R4362:Dus4l	UTSW	12	31,698,827 (GRCm39)	missense	probably damaging	1.00
R5425:Dus4l	UTSW	12	31,690,807 (GRCm39)	missense	probably damaging	1.00
R5568:Dus4l	UTSW	12	31,696,712 (GRCm39)	missense	probably damaging	1.00
R7188:Dus4l	UTSW	12	31,696,714 (GRCm39)	missense	probably damaging	1.00
R8184:Dus4l	UTSW	12	31,690,817 (GRCm39)	missense	probably damaging	1.00
R8900:Dus4l	UTSW	12	31,690,692 (GRCm39)	missense	possibly damaging	0.51
R9696:Dus4l	UTSW	12	31,696,647 (GRCm39)	missense	probably damaging	0.97
R9801:Dus4l	UTSW	12	31,698,827 (GRCm39)	missense	probably damaging	0.99

Posted On

2013-11-11