Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01446:Phf11b'

84408

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Phf11b

Ensembl Gene

ENSMUSG00000091649

Gene Name

PHD finger protein 11B

Synonyms

Gm4902

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.092) question?

Stock #

IGL01446

Quality Score

Status

Chromosome

Chromosomal Location

59558413-59578800 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 59578740 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Alanine at position 9 (S9A)

Ref Sequence

ENSEMBL: ENSMUSP00000127857 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000166121]

AlphaFold

B4XVQ1

Predicted Effect

probably benign
Transcript: ENSMUST00000166121
AA Change: S9A

PolyPhen 2 Score 0.016 (Sensitivity: 0.95; Specificity: 0.79)

SMART Domains

Protein: ENSMUSP00000127857
Gene: ENSMUSG00000091649
AA Change: S9A

Domain	Start	End	E-Value	Type
PHD	92	143	1.55e-1	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca13	A	G	11: 9,353,834 (GRCm39)	T3719A	probably damaging	Het
Acaca	A	G	11: 84,151,457 (GRCm39)	K785R	probably damaging	Het
Acsm3	G	A	7: 119,377,677 (GRCm39)	V401M	probably damaging	Het
Aff4	G	T	11: 53,306,296 (GRCm39)	R1146L	probably damaging	Het
Alms1	C	A	6: 85,673,683 (GRCm39)	P3562T	probably damaging	Het
Arsj	A	G	3: 126,232,463 (GRCm39)	E403G	probably benign	Het
Baiap2l1	C	T	5: 144,212,723 (GRCm39)	V431I	probably benign	Het
Cecr2	T	A	6: 120,735,560 (GRCm39)	M904K	probably benign	Het
Cenpe	A	T	3: 134,943,300 (GRCm39)	T775S	probably benign	Het
Dennd1b	G	A	1: 138,950,848 (GRCm39)	E30K	possibly damaging	Het
Dnah5	A	G	15: 28,326,815 (GRCm39)	D2008G	probably damaging	Het
Dnm2	T	C	9: 21,392,672 (GRCm39)	V460A	probably damaging	Het
Ell2	G	T	13: 75,910,110 (GRCm39)	L285F	probably benign	Het
Erg	A	G	16: 95,162,141 (GRCm39)	S322P	probably damaging	Het
Extl3	A	G	14: 65,314,529 (GRCm39)	F218L	probably benign	Het
Fzd9	T	C	5: 135,279,420 (GRCm39)	E155G	probably damaging	Het
Ghr	A	G	15: 3,362,837 (GRCm39)	W212R	probably damaging	Het
Gulp1	A	G	1: 44,783,708 (GRCm39)		probably benign	Het
Hdgfl2	C	T	17: 56,404,281 (GRCm39)	R332C	possibly damaging	Het
Lratd1	A	T	12: 14,199,929 (GRCm39)	I266N	probably damaging	Het
Nsd2	T	C	5: 34,018,530 (GRCm39)		probably benign	Het
Or4c12	A	G	2: 89,774,282 (GRCm39)	F59S	probably damaging	Het
Or5a3	T	C	19: 12,400,165 (GRCm39)	I164T	possibly damaging	Het
Or5b121	C	T	19: 13,507,616 (GRCm39)	T237I	probably benign	Het
Psd4	T	C	2: 24,295,407 (GRCm39)	S854P	probably damaging	Het
Reln	C	T	5: 22,174,315 (GRCm39)	D1963N	probably damaging	Het
Rpe65	T	A	3: 159,306,042 (GRCm39)		probably benign	Het
Sdccag8	T	C	1: 176,672,811 (GRCm39)	S235P	probably damaging	Het
Sgip1	G	T	4: 102,786,110 (GRCm39)		probably null	Het
Skint5	G	A	4: 113,800,019 (GRCm39)	P36L	probably damaging	Het
Slc26a3	G	T	12: 31,502,490 (GRCm39)		probably benign	Het
Snx13	T	A	12: 35,174,479 (GRCm39)	C669*	probably null	Het
Svil	A	T	18: 5,062,385 (GRCm39)	T902S	probably damaging	Het
Syne2	T	C	12: 76,088,149 (GRCm39)	S4989P	probably damaging	Het
Ttn	G	A	2: 76,640,283 (GRCm39)	T13775M	probably damaging	Het
Ubr4	T	C	4: 139,165,351 (GRCm39)		probably benign	Het
Ush1c	C	T	7: 45,858,380 (GRCm39)	R636H	possibly damaging	Het
Usp17lc	A	T	7: 103,067,651 (GRCm39)	R315S	probably benign	Het
Vmn1r236	T	A	17: 21,506,918 (GRCm39)	V12D	probably benign	Het
Wsb2	T	G	5: 117,509,229 (GRCm39)	I170S	probably damaging	Het
Zfp800	G	A	6: 28,242,983 (GRCm39)	L661F	possibly damaging	Het

Other mutations in Phf11b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00560:Phf11b	APN	14	59,562,324 (GRCm39)	missense	probably damaging	1.00
IGL01116:Phf11b	APN	14	59,560,631 (GRCm39)	missense	probably benign	0.02
IGL02224:Phf11b	APN	14	59,563,515 (GRCm39)	splice site	probably benign
IGL03062:Phf11b	APN	14	59,562,373 (GRCm39)	missense	probably damaging	1.00
PIT4131001:Phf11b	UTSW	14	59,560,611 (GRCm39)	splice site	probably benign
R1795:Phf11b	UTSW	14	59,565,554 (GRCm39)	missense	probably benign	0.00
R3774:Phf11b	UTSW	14	59,563,506 (GRCm39)	missense	probably benign	0.45
R4553:Phf11b	UTSW	14	59,578,734 (GRCm39)	missense	probably benign	0.10
R5460:Phf11b	UTSW	14	59,568,713 (GRCm39)	missense	probably benign	0.01
R5620:Phf11b	UTSW	14	59,558,953 (GRCm39)	missense	probably benign	0.01
R5985:Phf11b	UTSW	14	59,559,027 (GRCm39)	missense	possibly damaging	0.52
R5990:Phf11b	UTSW	14	59,562,375 (GRCm39)	missense	possibly damaging	0.57
R6775:Phf11b	UTSW	14	59,576,094 (GRCm39)	missense	probably benign	0.14
R6836:Phf11b	UTSW	14	59,565,572 (GRCm39)	missense	possibly damaging	0.81
R7197:Phf11b	UTSW	14	59,563,507 (GRCm39)	missense	probably benign	0.06
R7953:Phf11b	UTSW	14	59,568,722 (GRCm39)	missense	probably benign	0.35
R8043:Phf11b	UTSW	14	59,568,722 (GRCm39)	missense	probably benign	0.35
R8229:Phf11b	UTSW	14	59,568,730 (GRCm39)	missense	probably damaging	1.00
R8319:Phf11b	UTSW	14	59,576,146 (GRCm39)	missense	probably damaging	1.00
R9585:Phf11b	UTSW	14	59,568,704 (GRCm39)	missense	probably benign	0.02

Posted On

2013-11-11