Incidental Mutation 'IGL01455:Adgra3'
ID84765
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Adgra3
Ensembl Gene ENSMUSG00000029090
Gene Nameadhesion G protein-coupled receptor A3
SynonymsGpr125, Tem5-like, 3830613O22Rik
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL01455
Quality Score
Status
Chromosome5
Chromosomal Location49959956-50059006 bp(-) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) G to A at 49987557 bp
ZygosityHeterozygous
Amino Acid Change Arginine to Stop codon at position 565 (R565*)
Ref Sequence ENSEMBL: ENSMUSP00000030971 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030971]
Predicted Effect probably null
Transcript: ENSMUST00000030971
AA Change: R565*
SMART Domains Protein: ENSMUSP00000030971
Gene: ENSMUSG00000029090
AA Change: R565*

DomainStartEndE-ValueType
signal peptide 1 27 N/A INTRINSIC
low complexity region 36 48 N/A INTRINSIC
LRR 68 92 1.71e1 SMART
LRR_TYP 93 116 2.27e-4 SMART
LRR_TYP 117 140 4.11e-2 SMART
LRR_TYP 141 164 3.89e-3 SMART
LRRCT 176 225 5.24e-5 SMART
IG 238 331 8.26e-5 SMART
GPS 686 738 4.81e-3 SMART
Pfam:7tm_2 746 1031 1.6e-16 PFAM
low complexity region 1251 1262 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000198818
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the G protein-coupled receptor superfamily. This membrane protein may play a role in tumor angiogenesis through its interaction with the human homolog of the Drosophila disc large tumor suppressor gene. This gene is mapped to a candidate region of chromosome 4 which may be associated with bipolar disorder and schizophrenia. [provided by RefSeq, Oct 2012]
PHENOTYPE: Homozygous mutant mice are fertile and grossly normal. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsl6 A G 11: 54,323,305 D87G possibly damaging Het
Akap12 C T 10: 4,356,886 T1232I probably damaging Het
B3gnt2 A T 11: 22,837,042 W49R probably damaging Het
Ccdc112 T A 18: 46,293,444 K137N possibly damaging Het
Ccdc117 G T 11: 5,534,297 T181K possibly damaging Het
Cfh T C 1: 140,105,539 K756E possibly damaging Het
Clca1 C T 3: 145,007,778 M697I probably benign Het
Cyp2c29 T A 19: 39,329,117 I349K possibly damaging Het
Dcaf15 T C 8: 84,098,590 T434A probably benign Het
Entpd5 T C 12: 84,394,677 I106V probably benign Het
Eps8l1 T A 7: 4,478,923 probably benign Het
Erbin G T 13: 103,859,387 P269Q probably damaging Het
Fam172a A T 13: 77,902,647 probably benign Het
Fbxw22 C T 9: 109,384,994 M251I probably benign Het
Fgd4 T A 16: 16,490,490 T9S probably benign Het
Gm17689 T A 9: 36,581,363 H82L probably benign Het
Haus8 T C 8: 71,253,231 I270V probably benign Het
Herc4 T A 10: 63,286,143 probably null Het
Hspg2 G A 4: 137,553,817 V3367M probably damaging Het
Htr1f A T 16: 64,926,022 F302L probably damaging Het
Inpp5f T C 7: 128,678,049 C458R probably damaging Het
Klhl18 T C 9: 110,432,443 E411G probably damaging Het
Krt20 A T 11: 99,431,943 F289I probably benign Het
Mical1 T C 10: 41,479,069 probably null Het
Nav1 T C 1: 135,469,635 D932G probably benign Het
Nme4 A T 17: 26,092,062 D176E probably benign Het
Nox4 C T 7: 87,376,216 S517L possibly damaging Het
Olfr341 A T 2: 36,479,356 L258H probably damaging Het
Pip5k1a T C 3: 95,068,160 D333G probably benign Het
Polb T C 8: 22,653,072 Y36C probably damaging Het
Spta1 T C 1: 174,203,311 I953T possibly damaging Het
Sptb A T 12: 76,612,912 D1071E probably damaging Het
Stxbp3-ps T C 19: 9,558,007 noncoding transcript Het
Tmcc3 A T 10: 94,586,755 I356F probably damaging Het
Tmem262 G T 19: 6,080,159 R6L probably damaging Het
Tnks C A 8: 34,940,900 V225L probably damaging Het
Other mutations in Adgra3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00777:Adgra3 APN 5 50025758 missense probably damaging 1.00
IGL00848:Adgra3 APN 5 50001949 missense probably damaging 1.00
IGL01665:Adgra3 APN 5 50006930 missense possibly damaging 0.64
IGL02151:Adgra3 APN 5 49979142 missense probably benign
IGL02239:Adgra3 APN 5 49960712 missense probably damaging 1.00
IGL02351:Adgra3 APN 5 50058558 missense probably benign 0.19
IGL02358:Adgra3 APN 5 50058558 missense probably benign 0.19
IGL02938:Adgra3 APN 5 49961317 missense probably benign 0.01
IGL03028:Adgra3 APN 5 50016852 missense probably benign 0.30
aperture UTSW 5 49999145 nonsense probably null
saltatory UTSW 5 49960559 missense probably benign 0.09
ANU74:Adgra3 UTSW 5 49961038 missense probably benign 0.16
R0041:Adgra3 UTSW 5 49960559 missense probably benign 0.09
R0121:Adgra3 UTSW 5 50025786 splice site probably benign
R0125:Adgra3 UTSW 5 50001852 splice site probably benign
R0137:Adgra3 UTSW 5 49963840 splice site probably benign
R0415:Adgra3 UTSW 5 49961757 splice site probably benign
R0479:Adgra3 UTSW 5 49990265 missense probably benign 0.00
R0505:Adgra3 UTSW 5 50009334 critical splice donor site probably null
R0831:Adgra3 UTSW 5 49970802 missense probably damaging 1.00
R0883:Adgra3 UTSW 5 49960723 missense probably damaging 1.00
R0920:Adgra3 UTSW 5 49961161 missense probably benign 0.19
R1139:Adgra3 UTSW 5 49961755 splice site probably null
R1211:Adgra3 UTSW 5 50006876 missense possibly damaging 0.88
R1370:Adgra3 UTSW 5 49960787 missense possibly damaging 0.56
R1530:Adgra3 UTSW 5 49961137 missense probably benign 0.00
R1703:Adgra3 UTSW 5 50006775 missense probably benign 0.00
R1782:Adgra3 UTSW 5 49972062 missense probably benign 0.02
R1843:Adgra3 UTSW 5 49961492 missense probably damaging 1.00
R2157:Adgra3 UTSW 5 50001941 missense possibly damaging 0.87
R2281:Adgra3 UTSW 5 50001880 missense probably benign 0.04
R2385:Adgra3 UTSW 5 49979566 missense possibly damaging 0.95
R2426:Adgra3 UTSW 5 50009449 missense possibly damaging 0.61
R3084:Adgra3 UTSW 5 50013391 critical splice donor site probably null
R3086:Adgra3 UTSW 5 50013391 critical splice donor site probably null
R3409:Adgra3 UTSW 5 50001930 missense probably damaging 1.00
R3410:Adgra3 UTSW 5 50001930 missense probably damaging 1.00
R3411:Adgra3 UTSW 5 50001930 missense probably damaging 1.00
R4301:Adgra3 UTSW 5 49961078 missense possibly damaging 0.94
R4360:Adgra3 UTSW 5 49990210 missense possibly damaging 0.92
R4475:Adgra3 UTSW 5 50001898 missense probably damaging 1.00
R4569:Adgra3 UTSW 5 49960563 missense probably damaging 1.00
R4607:Adgra3 UTSW 5 49970739 missense probably damaging 0.98
R4667:Adgra3 UTSW 5 49978956 missense possibly damaging 0.94
R4671:Adgra3 UTSW 5 49979368 missense probably damaging 1.00
R4886:Adgra3 UTSW 5 49999195 missense probably benign 0.07
R5197:Adgra3 UTSW 5 49960754 missense probably benign 0.01
R5208:Adgra3 UTSW 5 50011515 missense probably damaging 0.99
R5313:Adgra3 UTSW 5 49961309 missense probably benign 0.24
R5435:Adgra3 UTSW 5 49990126 missense probably damaging 0.99
R5663:Adgra3 UTSW 5 49999285 missense probably benign 0.14
R6038:Adgra3 UTSW 5 49999145 nonsense probably null
R6038:Adgra3 UTSW 5 49999145 nonsense probably null
R6064:Adgra3 UTSW 5 49960325 missense probably damaging 0.97
R6259:Adgra3 UTSW 5 49999141 missense possibly damaging 0.63
R6272:Adgra3 UTSW 5 50009449 missense possibly damaging 0.61
R6293:Adgra3 UTSW 5 49960847 missense probably benign 0.21
R6296:Adgra3 UTSW 5 49960847 missense probably benign 0.21
R6297:Adgra3 UTSW 5 49960847 missense probably benign 0.21
R6352:Adgra3 UTSW 5 49979136 missense probably benign
R6352:Adgra3 UTSW 5 49990250 missense probably benign 0.01
R6989:Adgra3 UTSW 5 50006884 missense probably damaging 1.00
X0065:Adgra3 UTSW 5 49971962 missense probably benign
Posted On2013-11-11