Incidental Mutation 'IGL01457:Tst'
ID 84835
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tst
Ensembl Gene ENSMUSG00000044986
Gene Name thiosulfate sulfurtransferase, mitochondrial
Synonyms Rhodanese
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01457
Quality Score
Status
Chromosome 15
Chromosomal Location 78283756-78290065 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 78283967 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 287 (T287A)
Ref Sequence ENSEMBL: ENSMUSP00000055743 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058659] [ENSMUST00000074380] [ENSMUST00000165170] [ENSMUST00000229878]
AlphaFold P52196
Predicted Effect probably benign
Transcript: ENSMUST00000058659
AA Change: T287A

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
SMART Domains Protein: ENSMUSP00000055743
Gene: ENSMUSG00000044986
AA Change: T287A

DomainStartEndE-ValueType
RHOD 11 140 2.88e-18 SMART
RHOD 163 285 1.48e-20 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000074380
SMART Domains Protein: ENSMUSP00000073984
Gene: ENSMUSG00000062154

DomainStartEndE-ValueType
low complexity region 47 61 N/A INTRINSIC
low complexity region 63 71 N/A INTRINSIC
Pfam:TEX33 128 266 4.2e-73 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000165170
SMART Domains Protein: ENSMUSP00000133264
Gene: ENSMUSG00000062154

DomainStartEndE-ValueType
low complexity region 47 61 N/A INTRINSIC
low complexity region 63 71 N/A INTRINSIC
Pfam:TEX33 128 265 1.7e-73 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000229479
Predicted Effect probably benign
Transcript: ENSMUST00000229878
Predicted Effect noncoding transcript
Transcript: ENSMUST00000231525
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This is one of two neighboring genes encoding similar proteins that each contain two rhodanese domains. The encoded protein is localized to the mitochondria and catalyzes the conversion of thiosulfate and cyanide to thiocyanate and sulfite. In addition, the protein interacts with 5S ribosomal RNA and facilitates its import into the mitochondria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3425401B19Rik T A 14: 32,382,908 (GRCm39) Y1019F probably benign Het
4930455H04Rik T G 3: 116,762,200 (GRCm39) probably benign Het
9830107B12Rik A T 17: 48,439,193 (GRCm39) probably benign Het
Abcc8 A G 7: 45,784,917 (GRCm39) V737A possibly damaging Het
Adamts20 T A 15: 94,229,329 (GRCm39) Y930F probably damaging Het
Alkbh8 T A 9: 3,369,825 (GRCm39) F365I probably damaging Het
App G A 16: 84,900,127 (GRCm39) H108Y probably damaging Het
Bfsp1 T C 2: 143,669,564 (GRCm39) probably benign Het
Bltp3b T C 10: 89,641,624 (GRCm39) S932P probably benign Het
Cabin1 T C 10: 75,578,263 (GRCm39) N478S probably damaging Het
Camsap3 G A 8: 3,654,795 (GRCm39) V796I probably damaging Het
Carns1 A T 19: 4,216,498 (GRCm39) probably null Het
Ccdc121 A T 5: 31,644,771 (GRCm39) I175L probably benign Het
Clca3a1 C T 3: 144,713,539 (GRCm39) M697I probably benign Het
Cltc C T 11: 86,593,074 (GRCm39) M1600I probably benign Het
Cnot1 T A 8: 96,467,637 (GRCm39) N1499Y probably damaging Het
Crebbp T A 16: 3,942,632 (GRCm39) I196L probably damaging Het
Drc3 C A 11: 60,249,475 (GRCm39) probably benign Het
Fam161a T A 11: 22,970,702 (GRCm39) Y234* probably null Het
Il1r1 C A 1: 40,352,330 (GRCm39) P500Q probably damaging Het
Katnal1 G T 5: 148,830,607 (GRCm39) probably benign Het
Klhdc2 A G 12: 69,343,827 (GRCm39) N20S probably benign Het
Kmt2e A T 5: 23,707,017 (GRCm39) T1527S possibly damaging Het
Magi1 C T 6: 93,724,205 (GRCm39) G270D probably damaging Het
Mdn1 T A 4: 32,715,922 (GRCm39) S2035T possibly damaging Het
Mki67 A T 7: 135,301,275 (GRCm39) M1253K probably benign Het
Myh7 T C 14: 55,226,336 (GRCm39) M435V possibly damaging Het
Myh8 A G 11: 67,183,505 (GRCm39) I739V probably benign Het
Npnt T C 3: 132,591,743 (GRCm39) K430R probably damaging Het
Nrdc A G 4: 108,904,857 (GRCm39) N696S probably benign Het
Oit3 T C 10: 59,261,306 (GRCm39) probably benign Het
Or51a10 A G 7: 103,699,376 (GRCm39) Y62H probably damaging Het
Or51s1 A G 7: 102,558,926 (GRCm39) I40T possibly damaging Het
Or5bw2 A G 7: 6,573,211 (GRCm39) T74A probably benign Het
Or5p6 A T 7: 107,631,328 (GRCm39) I74K possibly damaging Het
Pkd1 G A 17: 24,813,795 (GRCm39) probably null Het
Plat A G 8: 23,266,844 (GRCm39) M279V probably benign Het
Prkd1 A T 12: 50,439,693 (GRCm39) L378* probably null Het
Rasgef1a C T 6: 118,061,506 (GRCm39) T157I probably benign Het
Rbm22 A G 18: 60,693,929 (GRCm39) N11S probably damaging Het
Ros1 T C 10: 51,922,426 (GRCm39) probably benign Het
Sema6d T A 2: 124,495,562 (GRCm39) F3Y unknown Het
Sis T C 3: 72,868,354 (GRCm39) D112G probably benign Het
Slit1 C A 19: 41,599,483 (GRCm39) G1023C probably damaging Het
Spata31h1 C A 10: 82,120,568 (GRCm39) K4147N probably damaging Het
Sptb T C 12: 76,659,329 (GRCm39) probably benign Het
Sspo T C 6: 48,475,277 (GRCm39) I4881T probably benign Het
Supt6 C A 11: 78,111,969 (GRCm39) D1038Y probably damaging Het
Tbc1d2b A T 9: 90,087,144 (GRCm39) L945Q probably damaging Het
Tgfbr3 G T 5: 107,297,764 (GRCm39) A212E probably damaging Het
Tipin A G 9: 64,211,690 (GRCm39) T259A probably benign Het
Traip T C 9: 107,847,671 (GRCm39) S365P probably benign Het
Tube1 C T 10: 39,021,718 (GRCm39) probably benign Het
Vmn1r37 T A 6: 66,708,393 (GRCm39) N6K probably damaging Het
Vmn2r111 C A 17: 22,790,966 (GRCm39) E111* probably null Het
Vmn2r17 C T 5: 109,600,898 (GRCm39) T732I probably benign Het
Vmn2r69 A T 7: 85,055,836 (GRCm39) D767E possibly damaging Het
Other mutations in Tst
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00435:Tst APN 15 78,289,661 (GRCm39) missense probably damaging 1.00
IGL01622:Tst APN 15 78,283,964 (GRCm39) missense probably benign 0.06
IGL01623:Tst APN 15 78,283,964 (GRCm39) missense probably benign 0.06
IGL03277:Tst APN 15 78,289,521 (GRCm39) missense probably damaging 1.00
R0456:Tst UTSW 15 78,289,780 (GRCm39) missense probably damaging 1.00
R1522:Tst UTSW 15 78,284,143 (GRCm39) missense possibly damaging 0.67
R2518:Tst UTSW 15 78,290,033 (GRCm39) start codon destroyed probably null 0.98
R5456:Tst UTSW 15 78,284,158 (GRCm39) missense probably damaging 1.00
R7623:Tst UTSW 15 78,289,903 (GRCm39) missense probably damaging 1.00
R7765:Tst UTSW 15 78,289,816 (GRCm39) missense possibly damaging 0.61
R8296:Tst UTSW 15 78,284,020 (GRCm39) missense probably damaging 1.00
R8520:Tst UTSW 15 78,289,453 (GRCm39) missense probably damaging 1.00
R9669:Tst UTSW 15 78,289,853 (GRCm39) missense probably benign 0.10
Posted On 2013-11-11