Incidental Mutation 'IGL01458:Zyg11a'
ID 84888
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zyg11a
Ensembl Gene ENSMUSG00000034645
Gene Name zyg-11 family member A, cell cycle regulator
Synonyms
Accession Numbers
Essential gene? Probably non essential (E-score: 0.129) question?
Stock # IGL01458
Quality Score
Status
Chromosome 4
Chromosomal Location 108038935-108075245 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 108062099 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 234 (T234I)
Ref Sequence ENSEMBL: ENSMUSP00000152477 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000043793] [ENSMUST00000106690] [ENSMUST00000223127]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000043793
AA Change: T232I

PolyPhen 2 Score 0.047 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000038478
Gene: ENSMUSG00000034645
AA Change: T232I

DomainStartEndE-ValueType
SCOP:d1jdha_ 218 700 2e-11 SMART
Blast:ARM 497 544 1e-5 BLAST
Blast:ARM 547 587 5e-7 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000106690
AA Change: T234I

PolyPhen 2 Score 0.086 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000102301
Gene: ENSMUSG00000034645
AA Change: T234I

DomainStartEndE-ValueType
SCOP:d1jdha_ 139 621 1e-11 SMART
Blast:ARM 418 465 1e-5 BLAST
Blast:ARM 468 508 1e-7 BLAST
Predicted Effect probably damaging
Transcript: ENSMUST00000223127
AA Change: T234I

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930433N12Rik A T 9: 3,134,008 (GRCm39) noncoding transcript Het
Akap12 A G 10: 4,304,060 (GRCm39) E290G probably damaging Het
Akap6 T A 12: 52,933,601 (GRCm39) C364* probably null Het
Akr1c18 A T 13: 4,187,143 (GRCm39) Y198N probably damaging Het
Aurka T C 2: 172,210,899 (GRCm39) probably benign Het
Bloc1s6 T A 2: 122,586,135 (GRCm39) probably null Het
Clca3a1 C T 3: 144,713,539 (GRCm39) M697I probably benign Het
Csn2 T C 5: 87,843,879 (GRCm39) probably benign Het
Dsc1 T C 18: 20,232,195 (GRCm39) E271G probably damaging Het
Eif1ad4 A T 12: 87,862,158 (GRCm39) K7* probably null Het
Evi5 G A 5: 107,963,513 (GRCm39) A354V probably damaging Het
Fcer2a T A 8: 3,738,151 (GRCm39) R137S probably benign Het
Fto A G 8: 92,168,344 (GRCm39) T266A probably benign Het
Fzd4 G A 7: 89,053,943 (GRCm39) V17I unknown Het
Gadd45b T C 10: 80,767,075 (GRCm39) L105P probably damaging Het
Galntl6 T C 8: 58,880,743 (GRCm39) S137G probably damaging Het
Gpr135 T C 12: 72,116,442 (GRCm39) M442V probably benign Het
Kcnq1 T A 7: 142,748,015 (GRCm39) Y330* probably null Het
Kdm5b A G 1: 134,549,724 (GRCm39) R1106G possibly damaging Het
Lrrc8e C T 8: 4,286,141 (GRCm39) R789W probably damaging Het
Myo16 T C 8: 10,485,853 (GRCm39) L644P probably damaging Het
Nbeal1 G T 1: 60,281,784 (GRCm39) probably null Het
Nlrp4c T C 7: 6,103,783 (GRCm39) C906R possibly damaging Het
Or10ag56 C T 2: 87,139,826 (GRCm39) T251I probably damaging Het
Or1e29 A T 11: 73,667,532 (GRCm39) I207N probably benign Het
Or1j15 T A 2: 36,458,754 (GRCm39) L48H probably damaging Het
Ovgp1 A G 3: 105,882,307 (GRCm39) N70D probably benign Het
Panx3 A T 9: 37,572,443 (GRCm39) M369K probably damaging Het
Plet1 A G 9: 50,406,017 (GRCm39) N52S probably benign Het
Prss1l T G 6: 41,373,621 (GRCm39) D161E probably benign Het
Psg18 A T 7: 18,088,741 (GRCm39) M1K probably null Het
Ptprz1 A T 6: 22,972,843 (GRCm39) D251V probably damaging Het
Serpinb6a A G 13: 34,114,064 (GRCm39) Y88H possibly damaging Het
Siglecf G A 7: 43,004,562 (GRCm39) R297Q possibly damaging Het
Tbx15 T C 3: 99,223,544 (GRCm39) V244A probably damaging Het
Top2a A T 11: 98,901,856 (GRCm39) L458Q probably damaging Het
Trim39 A G 17: 36,574,855 (GRCm39) probably benign Het
Vps37c T C 19: 10,687,781 (GRCm39) C81R probably damaging Het
Wdr62 A T 7: 29,941,187 (GRCm39) S744T probably benign Het
Other mutations in Zyg11a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01517:Zyg11a APN 4 108,058,391 (GRCm39) missense probably null 1.00
IGL01619:Zyg11a APN 4 108,062,414 (GRCm39) missense probably damaging 1.00
IGL02253:Zyg11a APN 4 108,040,892 (GRCm39) missense probably null 0.99
R0090:Zyg11a UTSW 4 108,058,544 (GRCm39) splice site probably benign
R0225:Zyg11a UTSW 4 108,061,838 (GRCm39) missense probably damaging 1.00
R0610:Zyg11a UTSW 4 108,062,054 (GRCm39) missense probably damaging 1.00
R0827:Zyg11a UTSW 4 108,067,239 (GRCm39) splice site probably benign
R1568:Zyg11a UTSW 4 108,040,843 (GRCm39) critical splice donor site probably null
R1752:Zyg11a UTSW 4 108,062,479 (GRCm39) missense possibly damaging 0.81
R2051:Zyg11a UTSW 4 108,049,244 (GRCm39) splice site probably benign
R2358:Zyg11a UTSW 4 108,053,343 (GRCm39) missense possibly damaging 0.94
R3898:Zyg11a UTSW 4 108,067,391 (GRCm39) missense probably damaging 0.99
R4288:Zyg11a UTSW 4 108,041,666 (GRCm39) missense probably damaging 1.00
R4381:Zyg11a UTSW 4 108,058,517 (GRCm39) missense possibly damaging 0.58
R4709:Zyg11a UTSW 4 108,062,268 (GRCm39) missense probably benign 0.00
R4859:Zyg11a UTSW 4 108,067,387 (GRCm39) missense probably damaging 0.98
R5303:Zyg11a UTSW 4 108,041,629 (GRCm39) critical splice donor site probably null
R5349:Zyg11a UTSW 4 108,040,929 (GRCm39) missense probably damaging 1.00
R5363:Zyg11a UTSW 4 108,046,819 (GRCm39) missense probably damaging 1.00
R5517:Zyg11a UTSW 4 108,061,943 (GRCm39) missense possibly damaging 0.94
R6175:Zyg11a UTSW 4 108,046,878 (GRCm39) missense probably benign 0.01
R6254:Zyg11a UTSW 4 108,038,991 (GRCm39) missense probably damaging 1.00
R6678:Zyg11a UTSW 4 108,046,878 (GRCm39) missense probably benign 0.01
R7524:Zyg11a UTSW 4 108,049,271 (GRCm39) missense probably damaging 1.00
R7789:Zyg11a UTSW 4 108,040,845 (GRCm39) missense probably damaging 1.00
R8022:Zyg11a UTSW 4 108,046,765 (GRCm39) critical splice donor site probably null
R8437:Zyg11a UTSW 4 108,075,103 (GRCm39) missense probably damaging 1.00
R8986:Zyg11a UTSW 4 108,041,628 (GRCm39) critical splice donor site probably null
R9129:Zyg11a UTSW 4 108,039,009 (GRCm39) missense probably benign 0.00
R9383:Zyg11a UTSW 4 108,046,926 (GRCm39) missense probably damaging 1.00
R9457:Zyg11a UTSW 4 108,075,102 (GRCm39) missense probably damaging 1.00
R9489:Zyg11a UTSW 4 108,062,376 (GRCm39) missense probably damaging 0.96
R9511:Zyg11a UTSW 4 108,062,420 (GRCm39) missense probably damaging 1.00
X0061:Zyg11a UTSW 4 108,051,190 (GRCm39) missense probably damaging 1.00
Z1176:Zyg11a UTSW 4 108,058,479 (GRCm39) missense probably damaging 1.00
Z1177:Zyg11a UTSW 4 108,061,997 (GRCm39) missense possibly damaging 0.90
Posted On 2013-11-11