Incidental Mutation 'R1083:Vmn1r14'
ID 84917
Institutional Source Beutler Lab
Gene Symbol Vmn1r14
Ensembl Gene ENSMUSG00000114982
Gene Name vomeronasal 1 receptor 14
Synonyms V1rc7
MMRRC Submission 039169-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.135) question?
Stock # R1083 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 57203140-57211335 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 57211184 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 210 (I210N)
Ref Sequence ENSEMBL: ENSMUSP00000153807 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000176376] [ENSMUST00000177435] [ENSMUST00000227209] [ENSMUST00000227574] [ENSMUST00000227768] [ENSMUST00000227884]
AlphaFold H3BJ46
Predicted Effect probably damaging
Transcript: ENSMUST00000176376
AA Change: I254N

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000134841
Gene: ENSMUSG00000093692
AA Change: I254N

DomainStartEndE-ValueType
low complexity region 1 11 N/A INTRINSIC
Pfam:V1R 35 303 2e-57 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000177435
AA Change: I254N

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000135207
Gene: ENSMUSG00000114982
AA Change: I254N

DomainStartEndE-ValueType
Pfam:V1R 28 293 3.9e-57 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000227209
AA Change: I210N

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000227574
AA Change: I210N

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000227768
AA Change: I254N

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
Predicted Effect probably damaging
Transcript: ENSMUST00000227884
AA Change: I254N

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.1%
  • 20x: 94.0%
Validation Efficiency 100% (38/38)
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A730049H05Rik T C 6: 92,805,046 (GRCm39) probably benign Het
Adamts17 G A 7: 66,797,322 (GRCm39) C986Y probably damaging Het
AI987944 A G 7: 41,024,763 (GRCm39) V75A probably benign Het
Arhgap10 T C 8: 78,244,378 (GRCm39) Y12C probably damaging Het
Atp11b G A 3: 35,832,162 (GRCm39) probably benign Het
Ccer1 T A 10: 97,530,520 (GRCm39) D394E possibly damaging Het
Cdh2 T C 18: 16,777,016 (GRCm39) N273S possibly damaging Het
Cfap65 G T 1: 74,957,663 (GRCm39) probably benign Het
Crybb3 A T 5: 113,228,444 (GRCm39) probably benign Het
D7Ertd443e G A 7: 133,950,663 (GRCm39) Q337* probably null Het
Dixdc1 C T 9: 50,588,293 (GRCm39) probably benign Het
Dut GCGGC GCGGCCGGC 2: 125,089,748 (GRCm39) probably null Het
Fbxo2 A G 4: 148,250,234 (GRCm39) probably null Het
Gm5174 T C 10: 86,491,972 (GRCm39) noncoding transcript Het
Gpam A G 19: 55,076,643 (GRCm39) probably benign Het
Il12a C T 3: 68,602,666 (GRCm39) T112M probably damaging Het
Itpr1 T A 6: 108,487,657 (GRCm39) V2361D possibly damaging Het
Jag1 G A 2: 136,938,152 (GRCm39) L283F probably damaging Het
Lamb2 A C 9: 108,360,892 (GRCm39) D538A probably benign Het
Map10 T A 8: 126,397,178 (GRCm39) C190* probably null Het
Pcnx2 C T 8: 126,498,843 (GRCm39) R1552H probably damaging Het
Phf1 T C 17: 27,156,244 (GRCm39) probably benign Het
Pitx2 A G 3: 129,012,418 (GRCm39) T276A probably damaging Het
Pparg A G 6: 115,467,107 (GRCm39) D490G probably damaging Het
Rnf10 A T 5: 115,398,163 (GRCm39) probably benign Het
Sbp T C 17: 24,161,704 (GRCm39) probably benign Het
Setbp1 A T 18: 78,900,841 (GRCm39) L942H probably damaging Het
Sf3b1 C G 1: 55,058,554 (GRCm39) E12Q possibly damaging Het
Sfmbt1 A T 14: 30,509,498 (GRCm39) N326Y possibly damaging Het
Slx4 G A 16: 3,808,774 (GRCm39) Q389* probably null Het
Srrm3 T A 5: 135,883,263 (GRCm39) V206E probably damaging Het
Sspo T A 6: 48,447,933 (GRCm39) D2270E possibly damaging Het
Sulf1 AAGGGA AAGGGAGGGA 1: 12,906,388 (GRCm39) probably null Het
Wasf3 T G 5: 146,372,182 (GRCm39) L13R probably damaging Het
Yes1 T C 5: 32,809,101 (GRCm39) probably null Het
Zfp292 T C 4: 34,807,569 (GRCm39) D1830G probably damaging Het
Zfp541 A G 7: 15,812,637 (GRCm39) N430S probably benign Het
Other mutations in Vmn1r14
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1533:Vmn1r14 UTSW 6 57,211,286 (GRCm39) missense probably damaging 1.00
R1759:Vmn1r14 UTSW 6 57,211,297 (GRCm39) missense probably benign 0.00
R3945:Vmn1r14 UTSW 6 57,211,254 (GRCm39) missense probably benign 0.13
R4034:Vmn1r14 UTSW 6 57,211,310 (GRCm39) missense possibly damaging 0.63
R4273:Vmn1r14 UTSW 6 57,211,133 (GRCm39) missense probably damaging 1.00
R4342:Vmn1r14 UTSW 6 57,210,808 (GRCm39) missense probably benign 0.09
R4451:Vmn1r14 UTSW 6 57,211,213 (GRCm39) missense possibly damaging 0.86
R5978:Vmn1r14 UTSW 6 57,210,929 (GRCm39) missense probably benign 0.06
R6378:Vmn1r14 UTSW 6 57,210,587 (GRCm39) missense probably benign 0.09
R6829:Vmn1r14 UTSW 6 57,210,536 (GRCm39) missense probably benign 0.06
R7153:Vmn1r14 UTSW 6 57,210,851 (GRCm39) missense probably benign 0.10
R8015:Vmn1r14 UTSW 6 57,211,015 (GRCm39) missense probably damaging 0.96
R8105:Vmn1r14 UTSW 6 57,211,245 (GRCm39) missense probably benign 0.00
R8830:Vmn1r14 UTSW 6 57,211,017 (GRCm39) missense probably damaging 0.98
R8831:Vmn1r14 UTSW 6 57,210,505 (GRCm39) missense probably benign 0.05
Z1177:Vmn1r14 UTSW 6 57,211,126 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- GAAGGTCACTAAATCCTGCTCACTCATC -3'
(R):5'- AAATCTAGCAGCACTAAGAATGCCAGTT -3'

Sequencing Primer
(F):5'- TTTAACAGTGATAAGCTCCAGGG -3'
(R):5'- GAATGCCAGTTTTTTACCACACG -3'
Posted On 2013-11-18