Incidental Mutation 'R1084:Ly6f'
ID 84973
Institutional Source Beutler Lab
Gene Symbol Ly6f
Ensembl Gene ENSMUSG00000022583
Gene Name lymphocyte antigen 6 family member F
Synonyms
MMRRC Submission 039170-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # R1084 (G1)
Quality Score 225
Status Validated
Chromosome 15
Chromosomal Location 75140270-75144084 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 75140622 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 15 (L15P)
Ref Sequence ENSEMBL: ENSMUSP00000140899 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023247] [ENSMUST00000189654]
AlphaFold P35460
Predicted Effect probably damaging
Transcript: ENSMUST00000023247
AA Change: L15P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000023247
Gene: ENSMUSG00000022583
AA Change: L15P

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
LU 27 118 1.94e-35 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000189654
AA Change: L15P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000140899
Gene: ENSMUSG00000022583
AA Change: L15P

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
LU 27 118 1.94e-35 SMART
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.7%
  • 3x: 99.0%
  • 10x: 97.3%
  • 20x: 93.7%
Validation Efficiency 100% (39/39)
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A1bg T A 15: 60,790,004 (GRCm39) probably benign Het
Abcg4 C T 9: 44,188,766 (GRCm39) V476M probably benign Het
Arhgap9 A G 10: 127,163,797 (GRCm39) S478G probably damaging Het
Blvra A G 2: 126,922,573 (GRCm39) T3A probably benign Het
Crygb C T 1: 65,119,654 (GRCm39) D109N possibly damaging Het
Cyp3a59 A T 5: 146,033,484 (GRCm39) T207S probably benign Het
Cyp4b1 A G 4: 115,497,509 (GRCm39) V163A probably benign Het
Dmxl2 A T 9: 54,323,717 (GRCm39) S1222R probably damaging Het
Dna2 C T 10: 62,784,966 (GRCm39) R28W probably benign Het
Dnah5 G A 15: 28,343,598 (GRCm39) V2333I probably benign Het
Eral1 C T 11: 77,965,324 (GRCm39) V364M probably damaging Het
Fat4 T C 3: 39,033,974 (GRCm39) V2542A possibly damaging Het
Glcci1 C T 6: 8,573,221 (GRCm39) Q50* probably null Het
Heg1 A G 16: 33,527,367 (GRCm39) D109G probably benign Het
Lama1 C A 17: 68,111,464 (GRCm39) S2238R probably benign Het
Ltbp1 G A 17: 75,666,420 (GRCm39) W1053* probably null Het
Mapk8 T A 14: 33,110,760 (GRCm39) K290* probably null Het
Mbd1 A G 18: 74,402,603 (GRCm39) Y35C probably damaging Het
Mcf2l T C 8: 13,052,645 (GRCm39) V503A possibly damaging Het
Morc2a A G 11: 3,600,454 (GRCm39) probably benign Het
Ms4a8a T A 19: 11,053,726 (GRCm39) I127F probably damaging Het
Myo1d T C 11: 80,575,221 (GRCm39) Y165C probably damaging Het
Ocel1 G T 8: 71,824,632 (GRCm39) probably null Het
Plekhh2 C T 17: 84,878,554 (GRCm39) T603M probably damaging Het
Rab6b C T 9: 103,039,834 (GRCm39) T128M probably damaging Het
Scel G T 14: 103,802,279 (GRCm39) probably null Het
Sec23a A T 12: 59,031,921 (GRCm39) N436K probably damaging Het
Sec24a A G 11: 51,604,408 (GRCm39) L736P probably damaging Het
Sf3b1 C G 1: 55,058,554 (GRCm39) E12Q possibly damaging Het
Sulf1 AAGGGA AAGGGAGGGA 1: 12,906,388 (GRCm39) probably null Het
Tex15 A G 8: 34,067,032 (GRCm39) E2154G probably benign Het
Tnrc18 A G 5: 142,750,522 (GRCm39) probably null Het
Tpr A G 1: 150,317,912 (GRCm39) Q2140R probably benign Het
Zfp142 T C 1: 74,610,985 (GRCm39) R834G probably benign Het
Zfp276 G A 8: 123,981,462 (GRCm39) R3Q probably damaging Het
Zscan4d A T 7: 10,898,932 (GRCm39) L115Q probably damaging Het
Other mutations in Ly6f
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0480:Ly6f UTSW 15 75,143,526 (GRCm39) missense probably damaging 1.00
R3036:Ly6f UTSW 15 75,140,636 (GRCm39) missense probably damaging 1.00
R3113:Ly6f UTSW 15 75,143,577 (GRCm39) missense probably benign 0.28
R4549:Ly6f UTSW 15 75,143,579 (GRCm39) missense probably benign
R4824:Ly6f UTSW 15 75,143,569 (GRCm39) missense probably damaging 0.99
R5148:Ly6f UTSW 15 75,143,646 (GRCm39) missense probably benign
R5211:Ly6f UTSW 15 75,143,652 (GRCm39) missense probably damaging 1.00
R5295:Ly6f UTSW 15 75,143,488 (GRCm39) missense probably benign 0.39
R9106:Ly6f UTSW 15 75,141,706 (GRCm39) missense probably damaging 1.00
R9455:Ly6f UTSW 15 75,141,648 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- AGAAACCCCTCCCTCTTCAGGATG -3'
(R):5'- CAGGGTTACAGACCCAGTAAAGCAC -3'

Sequencing Primer
(F):5'- ACATCTGACAGATCTTACCACTGTG -3'
(R):5'- GTAAAGCACACAACACATGAGG -3'
Posted On 2013-11-18