Incidental Mutation 'R1074:Vmn2r22'
| ID |
85566 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r22
|
| Ensembl Gene |
ENSMUSG00000095486 |
| Gene Name |
vomeronasal 2, receptor 22 |
| Synonyms |
EG546913 |
| MMRRC Submission |
039160-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.057)
|
| Stock # |
R1074 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
6 |
| Chromosomal Location |
123586717-123627594 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 123626217 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glycine
at position 73
(D73G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000132043
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000170808]
|
| AlphaFold |
E9Q7S8 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000170808
AA Change: D73G
PolyPhen 2
Score 0.016 (Sensitivity: 0.95; Specificity: 0.79)
|
| SMART Domains |
Protein: ENSMUSP00000132043
Gene: ENSMUSG00000095486
AA Change: D73G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
17 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
81 |
473 |
1.4e-32 |
PFAM |
|
Pfam:NCD3G
|
517 |
570 |
2.2e-23 |
PFAM |
|
Pfam:7tm_3
|
601 |
838 |
1.2e-54 |
PFAM |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.4%
- 3x: 98.8%
- 10x: 97.4%
- 20x: 94.9%
|
| Validation Efficiency |
97% (33/34) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 31 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aak1 |
T |
C |
6: 86,912,421 (GRCm39) |
S98P |
probably damaging |
Het |
| Abcb10 |
C |
T |
8: 124,688,791 (GRCm39) |
G495D |
probably damaging |
Het |
| Acbd3 |
C |
T |
1: 180,566,113 (GRCm39) |
Q269* |
probably null |
Het |
| Ankrd6 |
T |
C |
4: 32,822,232 (GRCm39) |
H179R |
probably damaging |
Het |
| Ano1 |
T |
A |
7: 144,165,417 (GRCm39) |
N603Y |
probably damaging |
Het |
| Catsperg1 |
T |
C |
7: 28,906,274 (GRCm39) |
E143G |
probably damaging |
Het |
| Epha5 |
G |
T |
5: 84,298,254 (GRCm39) |
A383E |
probably damaging |
Het |
| Epha5 |
C |
T |
5: 84,298,255 (GRCm39) |
A383T |
probably damaging |
Het |
| Epn1 |
T |
C |
7: 5,098,047 (GRCm39) |
V286A |
probably benign |
Het |
| Fam117b |
C |
T |
1: 59,997,485 (GRCm39) |
A279V |
possibly damaging |
Het |
| Impg2 |
G |
A |
16: 56,085,541 (GRCm39) |
|
probably benign |
Het |
| Man1a2 |
C |
T |
3: 100,563,402 (GRCm39) |
R81H |
possibly damaging |
Het |
| Medag |
G |
T |
5: 149,335,674 (GRCm39) |
V78L |
probably benign |
Het |
| Meioc |
C |
T |
11: 102,566,219 (GRCm39) |
H612Y |
probably damaging |
Het |
| Nab2 |
G |
A |
10: 127,499,124 (GRCm39) |
Q385* |
probably null |
Het |
| Ncor1 |
A |
G |
11: 62,283,377 (GRCm39) |
F437L |
probably damaging |
Het |
| Or10p1 |
T |
C |
10: 129,444,335 (GRCm39) |
N5S |
probably damaging |
Het |
| Or2n1 |
T |
C |
17: 38,486,331 (GRCm39) |
S119P |
probably damaging |
Het |
| Or8g18 |
G |
C |
9: 39,149,547 (GRCm39) |
P58A |
probably benign |
Het |
| Pcdhga1 |
A |
G |
18: 37,958,140 (GRCm39) |
|
probably benign |
Het |
| Pik3c2a |
G |
A |
7: 115,950,160 (GRCm39) |
R1286* |
probably null |
Het |
| Pira13 |
T |
C |
7: 3,826,069 (GRCm39) |
D308G |
probably damaging |
Het |
| Plk3 |
T |
C |
4: 116,988,955 (GRCm39) |
E268G |
probably damaging |
Het |
| Pzp |
T |
A |
6: 128,464,887 (GRCm39) |
N1329I |
probably benign |
Het |
| Reps1 |
A |
G |
10: 17,970,194 (GRCm39) |
T264A |
probably benign |
Het |
| Sp110 |
C |
G |
1: 85,516,839 (GRCm39) |
E219D |
probably damaging |
Het |
| Spata31e2 |
T |
C |
1: 26,722,307 (GRCm39) |
K958E |
probably benign |
Het |
| Srarp |
T |
A |
4: 141,160,707 (GRCm39) |
D42V |
probably damaging |
Het |
| Srbd1 |
T |
A |
17: 86,311,380 (GRCm39) |
H679L |
probably damaging |
Het |
| Tbc1d2b |
G |
A |
9: 90,104,393 (GRCm39) |
P583L |
possibly damaging |
Het |
| Zfp512b |
A |
T |
2: 181,230,972 (GRCm39) |
S374R |
probably damaging |
Het |
|
| Other mutations in Vmn2r22 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01024:Vmn2r22
|
APN |
6 |
123,615,012 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01764:Vmn2r22
|
APN |
6 |
123,627,379 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02037:Vmn2r22
|
APN |
6 |
123,626,026 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02183:Vmn2r22
|
APN |
6 |
123,614,963 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02335:Vmn2r22
|
APN |
6 |
123,615,051 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02440:Vmn2r22
|
APN |
6 |
123,614,364 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02663:Vmn2r22
|
APN |
6 |
123,626,117 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL03101:Vmn2r22
|
APN |
6 |
123,614,295 (GRCm39) |
missense |
probably benign |
0.09 |
|
R0266:Vmn2r22
|
UTSW |
6 |
123,614,363 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0348:Vmn2r22
|
UTSW |
6 |
123,614,684 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0780:Vmn2r22
|
UTSW |
6 |
123,614,933 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0849:Vmn2r22
|
UTSW |
6 |
123,614,363 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1456:Vmn2r22
|
UTSW |
6 |
123,614,624 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R1719:Vmn2r22
|
UTSW |
6 |
123,614,802 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1989:Vmn2r22
|
UTSW |
6 |
123,614,500 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2928:Vmn2r22
|
UTSW |
6 |
123,614,402 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2939:Vmn2r22
|
UTSW |
6 |
123,614,594 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3727:Vmn2r22
|
UTSW |
6 |
123,627,584 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R3782:Vmn2r22
|
UTSW |
6 |
123,627,591 (GRCm39) |
nonsense |
probably null |
|
|
R3873:Vmn2r22
|
UTSW |
6 |
123,614,339 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R4344:Vmn2r22
|
UTSW |
6 |
123,614,756 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4407:Vmn2r22
|
UTSW |
6 |
123,614,913 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4428:Vmn2r22
|
UTSW |
6 |
123,614,817 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R4430:Vmn2r22
|
UTSW |
6 |
123,614,817 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R4431:Vmn2r22
|
UTSW |
6 |
123,614,817 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R4701:Vmn2r22
|
UTSW |
6 |
123,627,428 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5274:Vmn2r22
|
UTSW |
6 |
123,627,593 (GRCm39) |
start codon destroyed |
probably null |
0.93 |
|
R5668:Vmn2r22
|
UTSW |
6 |
123,614,873 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5776:Vmn2r22
|
UTSW |
6 |
123,614,673 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6416:Vmn2r22
|
UTSW |
6 |
123,614,697 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7788:Vmn2r22
|
UTSW |
6 |
123,614,559 (GRCm39) |
missense |
not run |
|
|
R8208:Vmn2r22
|
UTSW |
6 |
123,614,444 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8267:Vmn2r22
|
UTSW |
6 |
123,615,000 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R8400:Vmn2r22
|
UTSW |
6 |
123,614,486 (GRCm39) |
nonsense |
probably null |
|
|
R8814:Vmn2r22
|
UTSW |
6 |
123,614,789 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8850:Vmn2r22
|
UTSW |
6 |
123,614,454 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9613:Vmn2r22
|
UTSW |
6 |
123,615,075 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCAAAACCATAGAACTTTTCATGGCCTT -3'
(R):5'- CACTTTGCAGTTGGGAACAATTTTCCTT -3'
Sequencing Primer
(F):5'- TCATCTCCGTAAAGTCAGCATTG -3'
(R):5'- ttgagaaacagaggcaggtag -3'
|
| Posted On |
2013-11-18 |
Incidental Mutation