Incidental Mutation 'R1078:Iltifb'
ID85740
Institutional Source Beutler Lab
Gene Symbol Iltifb
Ensembl Gene ENSMUSG00000090461
Gene Nameinterleukin 10-related T cell-derived inducible factor beta
SynonymsIL-TIFb
MMRRC Submission 039164-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.072) question?
Stock #R1078 (G1)
Quality Score225
Status Validated
Chromosome10
Chromosomal Location118289629-118295038 bp(-) (GRCm38)
Type of Mutationmakesense
DNA Base Change (assembly) T to G at 118290151 bp
ZygosityHeterozygous
Amino Acid Change Stop codon to Cysteine at position 180 (*180C)
Ref Sequence ENSEMBL: ENSMUSP00000128415 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000163808]
Predicted Effect probably null
Transcript: ENSMUST00000163808
AA Change: *180C
SMART Domains Protein: ENSMUSP00000128415
Gene: ENSMUSG00000090461
AA Change: *180C

DomainStartEndE-ValueType
IL10 49 179 5.21e-1 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000179123
Meta Mutation Damage Score 0.526 question?
Coding Region Coverage
  • 1x: 99.7%
  • 3x: 99.1%
  • 10x: 97.4%
  • 20x: 94.4%
Validation Efficiency 96% (53/55)
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
0610010F05Rik A C 11: 23,611,762 I358S probably benign Het
9130230L23Rik T C 5: 65,988,355 T138A unknown Het
Abi3bp T C 16: 56,654,081 probably null Het
Alpk3 A T 7: 81,078,600 M493L probably benign Het
Bace2 C T 16: 97,356,860 A20V unknown Het
Bms1 T C 6: 118,405,221 D452G probably benign Het
Ccdc187 T C 2: 26,294,377 T3A probably damaging Het
Ctu2 T C 8: 122,481,499 V95A possibly damaging Het
Cyp2a5 A G 7: 26,835,541 K60E probably benign Het
Cyp4f13 T C 17: 32,925,568 H318R probably damaging Het
Dlgap5 G A 14: 47,399,566 T485M probably damaging Het
Dsp C T 13: 38,183,106 probably benign Het
Ell2 T C 13: 75,746,419 probably benign Het
Eml2 A T 7: 19,179,762 Y168F probably benign Het
Ep400 C T 5: 110,735,522 probably benign Het
Ercc4 C A 16: 13,130,197 A336D probably benign Het
Fam189a2 T A 19: 23,973,575 R547S probably benign Het
Fat4 T C 3: 38,983,086 L3629S probably benign Het
Gabbr2 C T 4: 46,664,833 R925H probably damaging Het
Gfi1b A T 2: 28,613,865 W108R probably damaging Het
Gtse1 C T 15: 85,862,307 P108L probably damaging Het
Hfm1 A T 5: 106,878,830 F140I probably damaging Het
Hyal2 T A 9: 107,572,246 H400Q probably benign Het
Igfn1 A G 1: 135,974,847 Y371H probably damaging Het
Kdm2b T C 5: 122,961,541 T118A possibly damaging Het
Lama5 A T 2: 180,179,764 probably benign Het
Lgr6 C T 1: 134,994,010 A199T probably damaging Het
Lmo7 C T 14: 101,920,474 probably benign Het
Lrrc37a G T 11: 103,497,631 P2323T unknown Het
Lrrc38 A G 4: 143,350,518 Y117C probably benign Het
Myo1e T C 9: 70,383,999 V1024A probably benign Het
Myrfl T C 10: 116,776,732 N904S possibly damaging Het
Olfr1015 T C 2: 85,786,093 V194A possibly damaging Het
Olfr103 T A 17: 37,337,026 I69F probably damaging Het
Olfr1297 T C 2: 111,621,345 H243R probably damaging Het
Pld4 A T 12: 112,763,442 I53F probably benign Het
Plekhg4 T A 8: 105,381,677 C1117* probably null Het
Prss39 G A 1: 34,502,086 E224K probably benign Het
Psme1 G T 14: 55,580,650 G149V probably damaging Het
Soat2 T A 15: 102,153,138 probably null Het
Stab2 C T 10: 86,907,133 probably null Het
Tcf7l2 A G 19: 55,743,195 T127A probably benign Het
Tcp1 T C 17: 12,923,204 probably benign Het
Thbs4 G A 13: 92,762,926 probably benign Het
Tmf1 T C 6: 97,173,300 D482G probably damaging Het
Trim66 G T 7: 109,472,319 P591H probably damaging Het
Umodl1 T C 17: 30,959,373 S108P probably benign Het
Unc79 T G 12: 103,074,853 M715R probably benign Het
Usp34 C A 11: 23,433,175 probably benign Het
Utrn T G 10: 12,455,566 probably null Het
Zfp830 T C 11: 82,765,339 probably null Het
Other mutations in Iltifb
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01796:Iltifb APN 10 118290164 missense possibly damaging 0.70
IGL02149:Iltifb APN 10 118294997 utr 5 prime probably benign
IGL02965:Iltifb APN 10 118294857 missense probably damaging 0.98
R0310:Iltifb UTSW 10 118293185 missense probably benign 0.41
R0730:Iltifb UTSW 10 118294237 missense probably benign 0.01
R4067:Iltifb UTSW 10 118290210 missense probably damaging 0.99
R4158:Iltifb UTSW 10 118293132 missense probably damaging 1.00
R4911:Iltifb UTSW 10 118294989 start codon destroyed probably null 0.99
R5433:Iltifb UTSW 10 118294884 missense probably damaging 0.96
R5778:Iltifb UTSW 10 118294863 nonsense probably null
R7295:Iltifb UTSW 10 118294943 nonsense probably null
Predicted Primers PCR Primer
(F):5'- CCTCTGGTCTCATGGACAACTTGAC -3'
(R):5'- TATCACTTCCTGCTGCTTAGCACGG -3'

Sequencing Primer
(F):5'- CTCATGGACAACTTGACACTATTTTC -3'
(R):5'- cagtgtaatttgtgggatacagtg -3'
Posted On2013-11-18