Incidental Mutation 'R1079:Or5w8'
ID 85772
Institutional Source Beutler Lab
Gene Symbol Or5w8
Ensembl Gene ENSMUSG00000047039
Gene Name olfactory receptor family 5 subfamily W member 8
Synonyms MOR177-9, Olfr1151, GA_x6K02T2Q125-49358694-49359620
MMRRC Submission 039165-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.158) question?
Stock # R1079 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 87687521-87688447 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 87687699 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 60 (Y60C)
Ref Sequence ENSEMBL: ENSMUSP00000151107 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061081] [ENSMUST00000217376]
AlphaFold Q8VFQ8
Predicted Effect probably damaging
Transcript: ENSMUST00000061081
AA Change: Y60C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000055394
Gene: ENSMUSG00000047039
AA Change: Y60C

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 4.6e-45 PFAM
Pfam:7tm_1 41 290 1.7e-15 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000217376
AA Change: Y60C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Meta Mutation Damage Score 0.3745 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.9%
  • 10x: 97.6%
  • 20x: 95.6%
Validation Efficiency 98% (46/47)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2200002J24Rik T C 7: 30,399,209 (GRCm39) M1T probably null Het
Adam25 T C 8: 41,208,513 (GRCm39) V593A possibly damaging Het
Agrn C T 4: 156,261,682 (GRCm39) C536Y probably damaging Het
Amigo3 T C 9: 107,931,051 (GRCm39) M158T probably benign Het
Arsa G A 15: 89,358,428 (GRCm39) probably benign Het
Baz1a T A 12: 54,941,785 (GRCm39) I1474L possibly damaging Het
Cfap144 A G 11: 58,692,620 (GRCm39) Y36H probably benign Het
Cfap65 A G 1: 74,944,872 (GRCm39) V1455A probably damaging Het
Cfap65 G A 1: 74,941,606 (GRCm39) A1776V probably damaging Het
Cnot6 G T 11: 49,575,930 (GRCm39) D176E probably benign Het
Crot A T 5: 9,043,504 (GRCm39) probably null Het
Cryba2 A T 1: 74,929,717 (GRCm39) V140E probably damaging Het
Dennd4b G A 3: 90,178,485 (GRCm39) R516K probably benign Het
Dst C A 1: 34,225,944 (GRCm39) T1697N possibly damaging Het
Eftud2 G T 11: 102,730,870 (GRCm39) Y837* probably null Het
Evpl G T 11: 116,120,894 (GRCm39) T447K possibly damaging Het
Fndc3a A T 14: 72,827,247 (GRCm39) M146K possibly damaging Het
Folh1 G T 7: 86,421,089 (GRCm39) T80K probably damaging Het
Gm4922 T A 10: 18,660,086 (GRCm39) Y212F probably damaging Het
Gtf2i T G 5: 134,271,748 (GRCm39) probably benign Het
Hipk3 A G 2: 104,302,043 (GRCm39) F50L probably benign Het
Ifit1bl2 T A 19: 34,596,885 (GRCm39) T244S probably benign Het
Ikzf2 T C 1: 69,578,264 (GRCm39) D341G possibly damaging Het
Kif3a G C 11: 53,461,408 (GRCm39) V17L possibly damaging Het
Lgr6 C T 1: 134,921,748 (GRCm39) A199T probably damaging Het
Lzts2 T A 19: 45,011,983 (GRCm39) N137K probably damaging Het
Mphosph8 T A 14: 56,911,716 (GRCm39) D246E probably damaging Het
Myh14 T C 7: 44,279,426 (GRCm39) E918G probably damaging Het
N6amt1 T C 16: 87,153,086 (GRCm39) V52A probably damaging Het
Npr2 A C 4: 43,643,654 (GRCm39) T561P probably damaging Het
Nudt12 G A 17: 59,318,032 (GRCm39) probably benign Het
Or10ad1 A C 15: 98,106,223 (GRCm39) V14G probably damaging Het
Or6n2 A T 1: 173,897,032 (GRCm39) H56L possibly damaging Het
Or8k22 T A 2: 86,163,185 (GRCm39) R172W probably damaging Het
Pan2 A G 10: 128,154,107 (GRCm39) T1050A probably damaging Het
Rad17 G T 13: 100,770,407 (GRCm39) D213E probably benign Het
Sall2 T A 14: 52,550,660 (GRCm39) H843L probably benign Het
Sdk2 C T 11: 113,729,472 (GRCm39) silent Het
Sema3e A T 5: 14,275,669 (GRCm39) N258I probably benign Het
Siglec1 G A 2: 130,921,297 (GRCm39) R625* probably null Het
Slc15a3 T C 19: 10,833,344 (GRCm39) S454P probably benign Het
Sp110 G A 1: 85,516,825 (GRCm39) probably benign Het
Spatc1l T C 10: 76,399,741 (GRCm39) S88P probably damaging Het
Ssh3 A C 19: 4,316,577 (GRCm39) L143R probably damaging Het
Ttn C T 2: 76,587,340 (GRCm39) probably benign Het
Vps35 A G 8: 86,005,683 (GRCm39) L306S probably damaging Het
Zfp729a T C 13: 67,767,794 (GRCm39) I812V possibly damaging Het
Other mutations in Or5w8
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01755:Or5w8 APN 2 87,687,854 (GRCm39) missense possibly damaging 0.60
IGL02314:Or5w8 APN 2 87,688,400 (GRCm39) missense probably damaging 1.00
R0127:Or5w8 UTSW 2 87,687,827 (GRCm39) missense probably benign
R0233:Or5w8 UTSW 2 87,688,096 (GRCm39) missense probably benign 0.19
R0233:Or5w8 UTSW 2 87,688,096 (GRCm39) missense probably benign 0.19
R0398:Or5w8 UTSW 2 87,688,401 (GRCm39) missense probably damaging 1.00
R1598:Or5w8 UTSW 2 87,688,095 (GRCm39) missense probably benign 0.01
R1965:Or5w8 UTSW 2 87,687,759 (GRCm39) missense probably benign 0.44
R3409:Or5w8 UTSW 2 87,688,005 (GRCm39) nonsense probably null
R4824:Or5w8 UTSW 2 87,687,621 (GRCm39) missense probably benign 0.24
R4962:Or5w8 UTSW 2 87,687,632 (GRCm39) missense probably benign 0.02
R4986:Or5w8 UTSW 2 87,687,858 (GRCm39) missense probably damaging 0.97
R5324:Or5w8 UTSW 2 87,688,040 (GRCm39) missense probably damaging 1.00
R5934:Or5w8 UTSW 2 87,687,585 (GRCm39) missense probably benign
R6335:Or5w8 UTSW 2 87,687,811 (GRCm39) nonsense probably null
R6389:Or5w8 UTSW 2 87,688,367 (GRCm39) missense probably damaging 1.00
R6958:Or5w8 UTSW 2 87,688,295 (GRCm39) missense probably damaging 1.00
R7329:Or5w8 UTSW 2 87,687,585 (GRCm39) missense probably benign
R8228:Or5w8 UTSW 2 87,688,284 (GRCm39) missense probably benign 0.12
R8506:Or5w8 UTSW 2 87,688,181 (GRCm39) missense probably damaging 1.00
R8726:Or5w8 UTSW 2 87,688,161 (GRCm39) missense probably benign 0.14
R8845:Or5w8 UTSW 2 87,687,545 (GRCm39) missense probably benign 0.00
R9548:Or5w8 UTSW 2 87,688,040 (GRCm39) missense probably damaging 1.00
Z1177:Or5w8 UTSW 2 87,687,768 (GRCm39) missense probably benign 0.13
Predicted Primers PCR Primer
(F):5'- GGGAAACTGCTCCTCTGTGGATG -3'
(R):5'- CTCAGCAGAACGGATCTTCAGGAC -3'

Sequencing Primer
(F):5'- CCTGTCAAAAAAGTGGCCCT -3'
(R):5'- GTTGTTGCCACCAGGTAAAC -3'
Posted On 2013-11-18