Incidental Mutation 'R0714:Nrsn2'
ID 85895
Institutional Source Beutler Lab
Gene Symbol Nrsn2
Ensembl Gene ENSMUSG00000059361
Gene Name neurensin 2
Synonyms LOC228777, Neurensin-2
MMRRC Submission 038897-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.048) question?
Stock # R0714 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 152210675-152218558 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) G to A at 152216042 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Stop codon at position 54 (R54*)
Ref Sequence ENSEMBL: ENSMUSP00000078260 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079278]
AlphaFold Q5HZK2
Predicted Effect probably null
Transcript: ENSMUST00000079278
AA Change: R54*
SMART Domains Protein: ENSMUSP00000078260
Gene: ENSMUSG00000059361
AA Change: R54*

DomainStartEndE-ValueType
Pfam:Neurensin 20 154 1.5e-37 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000089083
Predicted Effect noncoding transcript
Transcript: ENSMUST00000128577
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.9%
  • 10x: 97.6%
  • 20x: 95.5%
Validation Efficiency 100% (52/52)
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd17b G A 19: 21,655,973 (GRCm39) R85H probably damaging Het
Adamts13 A G 2: 26,876,997 (GRCm39) probably benign Het
Alb T C 5: 90,610,665 (GRCm39) S82P possibly damaging Het
Arhgap10 G A 8: 78,078,316 (GRCm39) probably benign Het
Aspscr1 T A 11: 120,594,493 (GRCm39) probably null Het
Capn3 A T 2: 120,322,361 (GRCm39) Q359L probably benign Het
Ccdc110 A T 8: 46,396,047 (GRCm39) D646V possibly damaging Het
Ccr2 G A 9: 123,905,966 (GRCm39) G82D probably benign Het
Col6a4 A G 9: 105,895,102 (GRCm39) probably benign Het
Dhx29 T C 13: 113,064,499 (GRCm39) V58A possibly damaging Het
Dhx35 C A 2: 158,686,103 (GRCm39) Q593K probably benign Het
Dmd T C X: 83,353,503 (GRCm39) L2240P probably benign Het
Emc7 A G 2: 112,293,277 (GRCm39) N162S possibly damaging Het
Exoc7 A T 11: 116,184,120 (GRCm39) N483K probably benign Het
Fbxo34 T C 14: 47,767,486 (GRCm39) V282A probably damaging Het
Fndc3c1 A T X: 105,468,972 (GRCm39) Y1087* probably null Het
Kat2a A G 11: 100,602,178 (GRCm39) V192A probably damaging Het
Larp7 T C 3: 127,340,833 (GRCm39) D64G probably damaging Het
Lnx1 A G 5: 74,768,570 (GRCm39) probably benign Het
Mib2 C T 4: 155,743,917 (GRCm39) G42S probably damaging Het
Nckipsd C A 9: 108,691,333 (GRCm39) probably benign Het
Ndufab1 A G 7: 121,695,960 (GRCm39) probably benign Het
Nedd4 G A 9: 72,638,728 (GRCm39) probably benign Het
Nt5dc3 T A 10: 86,648,238 (GRCm39) V171E probably damaging Het
Nudt8 A G 19: 4,052,023 (GRCm39) *211W probably null Het
Nxph4 A G 10: 127,362,808 (GRCm39) S28P probably damaging Het
Or4f14b A G 2: 111,774,898 (GRCm39) V301A probably benign Het
Or8k17 A C 2: 86,066,498 (GRCm39) L227R probably damaging Het
Or9g4b A G 2: 85,616,743 (GRCm39) D296G probably damaging Het
Pcdhb15 A G 18: 37,607,674 (GRCm39) Y302C probably damaging Het
Pkdrej A G 15: 85,699,712 (GRCm39) S2075P possibly damaging Het
Sdhc A T 1: 170,957,488 (GRCm39) probably benign Het
Sidt2 A G 9: 45,858,358 (GRCm39) probably benign Het
Sik2 T C 9: 50,818,736 (GRCm39) M413V probably benign Het
Slc5a4b A G 10: 75,917,341 (GRCm39) F232L probably benign Het
Slx1b A T 7: 126,291,620 (GRCm39) I148N probably damaging Het
Spag17 C G 3: 99,987,472 (GRCm39) S1587R probably damaging Het
St13 T C 15: 81,267,228 (GRCm39) D74G probably benign Het
St7l G A 3: 104,782,244 (GRCm39) R207H probably benign Het
Syne2 AGAGTGAG AGAGTGAGTGAG 12: 76,144,734 (GRCm39) probably null Het
Tacc3 T C 5: 33,828,741 (GRCm39) probably benign Het
Tbx22 G A X: 106,728,731 (GRCm39) V421I probably benign Het
Tmc3 G A 7: 83,265,969 (GRCm39) A705T possibly damaging Het
Tmem130 C T 5: 144,674,619 (GRCm39) V369M probably damaging Het
Tonsl T C 15: 76,517,921 (GRCm39) probably benign Het
Trpm6 T A 19: 18,815,451 (GRCm39) I1179N possibly damaging Het
Ttc13 A T 8: 125,401,105 (GRCm39) S624T probably damaging Het
Utp23 T G 15: 51,745,665 (GRCm39) V55G possibly damaging Het
Vps11 A G 9: 44,270,953 (GRCm39) V143A possibly damaging Het
Vps50 G T 6: 3,571,105 (GRCm39) V618F probably benign Het
Other mutations in Nrsn2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03303:Nrsn2 APN 2 152,216,131 (GRCm39) missense possibly damaging 0.65
R0403:Nrsn2 UTSW 2 152,211,710 (GRCm39) missense probably damaging 1.00
R2570:Nrsn2 UTSW 2 152,211,741 (GRCm39) missense possibly damaging 0.55
R4840:Nrsn2 UTSW 2 152,211,552 (GRCm39) missense probably benign 0.42
R4856:Nrsn2 UTSW 2 152,211,531 (GRCm39) missense probably benign 0.09
R4886:Nrsn2 UTSW 2 152,211,531 (GRCm39) missense probably benign 0.09
R6641:Nrsn2 UTSW 2 152,211,830 (GRCm39) missense probably benign 0.02
R7796:Nrsn2 UTSW 2 152,218,471 (GRCm39) start gained probably benign
Predicted Primers PCR Primer
(F):5'- ACACCGTACTTTTGGCCCTTGAAC -3'
(R):5'- TGTTAAGCGGAAAACTCCTGGCTC -3'

Sequencing Primer
(F):5'- TTGGCCCTTGAACATGAAGAC -3'
(R):5'- CCTCACTCAGGGATGAAAGGC -3'
Posted On 2013-11-18