Incidental Mutation 'R1065:Commd7'
ID 85955
Institutional Source Beutler Lab
Gene Symbol Commd7
Ensembl Gene ENSMUSG00000056941
Gene Name COMM domain containing 7
Synonyms mU3, 2310010I22Rik
MMRRC Submission 039151-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.243) question?
Stock # R1065 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 153458853-153474701 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) G to C at 153461447 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000105404 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071852] [ENSMUST00000109782]
AlphaFold Q8BG94
Predicted Effect probably benign
Transcript: ENSMUST00000071852
SMART Domains Protein: ENSMUSP00000071752
Gene: ENSMUSG00000056941

DomainStartEndE-ValueType
Pfam:HCaRG 19 199 3.8e-44 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000109782
SMART Domains Protein: ENSMUSP00000105404
Gene: ENSMUSG00000056941

DomainStartEndE-ValueType
Pfam:HCaRG 1 127 4.4e-33 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147822
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.9%
  • 10x: 97.6%
  • 20x: 95.5%
Validation Efficiency 97% (36/37)
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Cd300ld2 T C 11: 114,904,586 (GRCm39) T94A probably damaging Het
Cdc42bpg G A 19: 6,372,856 (GRCm39) S1515N probably damaging Het
Ckb T C 12: 111,637,681 (GRCm39) E150G probably benign Het
Clec2m A G 6: 129,300,013 (GRCm39) I155T possibly damaging Het
Cobl T A 11: 12,204,327 (GRCm39) M785L possibly damaging Het
Col6a5 T C 9: 105,758,982 (GRCm39) N2075D probably damaging Het
Corin G A 5: 72,458,993 (GRCm39) R927* probably null Het
Dync2i1 C T 12: 116,219,696 (GRCm39) R82H probably damaging Het
Ift122 A T 6: 115,852,286 (GRCm39) probably null Het
Il1b G A 2: 129,209,927 (GRCm39) T83I probably benign Het
Ints4 T C 7: 97,157,099 (GRCm39) probably null Het
Msh6 T G 17: 88,295,891 (GRCm39) probably benign Het
Mtmr3 T C 11: 4,442,859 (GRCm39) K392E probably damaging Het
Or5t9 A G 2: 86,659,888 (GRCm39) H264R probably damaging Het
Pde3a T C 6: 141,422,458 (GRCm39) probably benign Het
Pde6h A C 6: 136,936,368 (GRCm39) K37T probably damaging Het
Plat C A 8: 23,266,879 (GRCm39) D290E probably damaging Het
Polk A C 13: 96,644,760 (GRCm39) L122R probably damaging Het
Ppp1r3g T A 13: 36,153,418 (GRCm39) D279E probably benign Het
Ptpru T C 4: 131,535,651 (GRCm39) E370G possibly damaging Het
Ralgapa2 T C 2: 146,292,478 (GRCm39) Y187C probably benign Het
Rps6ka2 C T 17: 7,549,157 (GRCm39) probably benign Het
Slit3 T C 11: 35,012,462 (GRCm39) S41P possibly damaging Het
Smarca5 A T 8: 81,431,343 (GRCm39) L958Q probably damaging Het
Snx9 T C 17: 5,952,636 (GRCm39) probably benign Het
Stkld1 A T 2: 26,830,050 (GRCm39) N72I probably damaging Het
Strc C A 2: 121,197,132 (GRCm39) D1532Y probably damaging Het
Sucla2 C T 14: 73,798,074 (GRCm39) probably benign Het
Svil T G 18: 5,063,777 (GRCm39) probably benign Het
Traf3ip1 T A 1: 91,428,506 (GRCm39) D122E unknown Het
Vmn2r7 A T 3: 64,614,559 (GRCm39) D509E possibly damaging Het
Vps52 C A 17: 34,180,213 (GRCm39) Q306K probably benign Het
Zfp407 C T 18: 84,577,898 (GRCm39) A1072T probably benign Het
Zfp418 C A 7: 7,184,561 (GRCm39) Q175K probably benign Het
Zxdc T C 6: 90,355,885 (GRCm39) S465P probably damaging Het
Other mutations in Commd7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03392:Commd7 APN 2 153,464,684 (GRCm39) splice site probably benign
R1131:Commd7 UTSW 2 153,464,047 (GRCm39) missense probably benign 0.00
R2132:Commd7 UTSW 2 153,463,586 (GRCm39) intron probably benign
R3897:Commd7 UTSW 2 153,464,710 (GRCm39) missense probably benign
R5837:Commd7 UTSW 2 153,471,144 (GRCm39) missense possibly damaging 0.79
R5902:Commd7 UTSW 2 153,463,737 (GRCm39) missense probably damaging 1.00
R6207:Commd7 UTSW 2 153,474,530 (GRCm39) missense possibly damaging 0.73
R9172:Commd7 UTSW 2 153,470,474 (GRCm39) missense possibly damaging 0.86
R9573:Commd7 UTSW 2 153,463,981 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGGACACAGTCCCAGATGCAGTAG -3'
(R):5'- AGCGAGTATAGATGTCAGCCTGGAG -3'

Sequencing Primer
(F):5'- TCTAGGTGTAAAGTCACCCAGG -3'
(R):5'- GATGGAGCCCTGGATACTTAAGG -3'
Posted On 2013-11-18