Incidental Mutation 'R1066:Tedc2'
ID 86026
Institutional Source Beutler Lab
Gene Symbol Tedc2
Ensembl Gene ENSMUSG00000024118
Gene Name tubulin epsilon and delta complex 2
Synonyms 1600002H07Rik
MMRRC Submission 039152-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.819) question?
Stock # R1066 (G1)
Quality Score 200
Status Not validated
Chromosome 17
Chromosomal Location 24434028-24439825 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to A at 24435292 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Stop codon at position 366 (E366*)
Ref Sequence ENSEMBL: ENSMUSP00000024930 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000024930]
AlphaFold Q6GQV0
Predicted Effect probably null
Transcript: ENSMUST00000024930
AA Change: E366*
SMART Domains Protein: ENSMUSP00000024930
Gene: ENSMUSG00000024118
AA Change: E366*

DomainStartEndE-ValueType
low complexity region 32 49 N/A INTRINSIC
low complexity region 78 84 N/A INTRINSIC
low complexity region 111 131 N/A INTRINSIC
Pfam:DUF4693 150 434 8.6e-145 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000124557
SMART Domains Protein: ENSMUSP00000119405
Gene: ENSMUSG00000024118

DomainStartEndE-ValueType
low complexity region 16 32 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137648
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137883
Predicted Effect noncoding transcript
Transcript: ENSMUST00000138818
Predicted Effect noncoding transcript
Transcript: ENSMUST00000148704
Predicted Effect noncoding transcript
Transcript: ENSMUST00000149916
Predicted Effect noncoding transcript
Transcript: ENSMUST00000171563
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.1%
  • 20x: 94.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts8 T A 9: 30,867,837 (GRCm39) C554S probably damaging Het
Adarb2 T G 13: 8,807,359 (GRCm39) F720C probably benign Het
Arid5b T C 10: 67,934,186 (GRCm39) D572G probably benign Het
BB014433 C T 8: 15,092,185 (GRCm39) V223M probably damaging Het
Boc T C 16: 44,311,047 (GRCm39) probably null Het
Brf2 T C 8: 27,613,974 (GRCm39) E404G probably benign Het
Ces3a T A 8: 105,782,288 (GRCm39) H380Q probably benign Het
Chd9 T A 8: 91,712,764 (GRCm39) Y389* probably null Het
Csmd3 A G 15: 47,777,361 (GRCm39) F1182L probably damaging Het
Dnah2 C A 11: 69,338,645 (GRCm39) W3169L probably damaging Het
Dnah3 T A 7: 119,660,232 (GRCm39) E802D probably damaging Het
Dtx4 G T 19: 12,478,373 (GRCm39) T70K probably damaging Het
Fat4 T C 3: 39,011,376 (GRCm39) Y2159H probably damaging Het
Flrt2 T A 12: 95,745,833 (GRCm39) V57E probably damaging Het
Gsdmc2 T A 15: 63,696,899 (GRCm39) Y424F possibly damaging Het
Igfn1 T C 1: 135,898,463 (GRCm39) E701G probably benign Het
Klhl42 T C 6: 147,009,397 (GRCm39) V412A probably benign Het
Mkln1 A C 6: 31,395,922 (GRCm39) N52T possibly damaging Het
Msantd5f6 C A 4: 73,320,066 (GRCm39) V238L possibly damaging Het
Myo15b A T 11: 115,770,577 (GRCm39) M1519L probably benign Het
Nup155 A T 15: 8,187,244 (GRCm39) H1391L probably damaging Het
Or5b113 T C 19: 13,342,451 (GRCm39) M153T probably benign Het
P4ha3 G T 7: 99,967,270 (GRCm39) V360L possibly damaging Het
Pals2 A T 6: 50,122,847 (GRCm39) N31I possibly damaging Het
Phf14 T A 6: 11,987,254 (GRCm39) D611E possibly damaging Het
Pik3r1 T A 13: 101,825,171 (GRCm39) R465S probably damaging Het
Reep3 G T 10: 66,870,445 (GRCm39) T117K probably damaging Het
Reln G T 5: 22,239,662 (GRCm39) N868K probably damaging Het
Sdcbp T G 4: 6,385,120 (GRCm39) I113S probably damaging Het
Sema4c A T 1: 36,589,281 (GRCm39) V615E possibly damaging Het
Slc25a18 A G 6: 120,765,249 (GRCm39) probably null Het
Uba2 A T 7: 33,858,247 (GRCm39) F70I probably damaging Het
Usp42 A T 5: 143,703,796 (GRCm39) H422Q probably damaging Het
Vmn2r86 C T 10: 130,282,145 (GRCm39) V824I probably benign Het
Vps50 A C 6: 3,533,565 (GRCm39) T266P probably damaging Het
Znhit6 T A 3: 145,284,252 (GRCm39) D141E probably damaging Het
Other mutations in Tedc2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01963:Tedc2 APN 17 24,436,926 (GRCm39) missense probably benign 0.01
IGL02111:Tedc2 APN 17 24,437,140 (GRCm39) splice site probably benign
IGL02347:Tedc2 APN 17 24,439,584 (GRCm39) missense probably damaging 1.00
IGL03400:Tedc2 APN 17 24,438,777 (GRCm39) missense probably benign
R0766:Tedc2 UTSW 17 24,435,292 (GRCm39) nonsense probably null
R0766:Tedc2 UTSW 17 24,435,291 (GRCm39) missense probably damaging 1.00
R1066:Tedc2 UTSW 17 24,435,291 (GRCm39) missense probably damaging 1.00
R1067:Tedc2 UTSW 17 24,435,292 (GRCm39) nonsense probably null
R1067:Tedc2 UTSW 17 24,435,291 (GRCm39) missense probably damaging 1.00
R1085:Tedc2 UTSW 17 24,435,292 (GRCm39) nonsense probably null
R1085:Tedc2 UTSW 17 24,435,291 (GRCm39) missense probably damaging 1.00
R1086:Tedc2 UTSW 17 24,435,292 (GRCm39) nonsense probably null
R1086:Tedc2 UTSW 17 24,435,291 (GRCm39) missense probably damaging 1.00
R1136:Tedc2 UTSW 17 24,435,292 (GRCm39) nonsense probably null
R1136:Tedc2 UTSW 17 24,435,291 (GRCm39) missense probably damaging 1.00
R1137:Tedc2 UTSW 17 24,435,292 (GRCm39) nonsense probably null
R1137:Tedc2 UTSW 17 24,435,291 (GRCm39) missense probably damaging 1.00
R1203:Tedc2 UTSW 17 24,435,291 (GRCm39) missense probably damaging 1.00
R1203:Tedc2 UTSW 17 24,435,292 (GRCm39) nonsense probably null
R1345:Tedc2 UTSW 17 24,435,292 (GRCm39) nonsense probably null
R1345:Tedc2 UTSW 17 24,435,291 (GRCm39) missense probably damaging 1.00
R1385:Tedc2 UTSW 17 24,435,292 (GRCm39) nonsense probably null
R1385:Tedc2 UTSW 17 24,435,291 (GRCm39) missense probably damaging 1.00
R1396:Tedc2 UTSW 17 24,435,292 (GRCm39) nonsense probably null
R1396:Tedc2 UTSW 17 24,435,291 (GRCm39) missense probably damaging 1.00
R1888:Tedc2 UTSW 17 24,435,291 (GRCm39) missense probably damaging 1.00
R1888:Tedc2 UTSW 17 24,435,291 (GRCm39) missense probably damaging 1.00
R1888:Tedc2 UTSW 17 24,435,292 (GRCm39) nonsense probably null
R1888:Tedc2 UTSW 17 24,435,292 (GRCm39) nonsense probably null
R1891:Tedc2 UTSW 17 24,435,292 (GRCm39) nonsense probably null
R1891:Tedc2 UTSW 17 24,435,291 (GRCm39) missense probably damaging 1.00
R1943:Tedc2 UTSW 17 24,436,923 (GRCm39) missense possibly damaging 0.90
R1984:Tedc2 UTSW 17 24,435,292 (GRCm39) nonsense probably null
R1984:Tedc2 UTSW 17 24,435,291 (GRCm39) missense probably damaging 1.00
R1985:Tedc2 UTSW 17 24,435,292 (GRCm39) nonsense probably null
R1985:Tedc2 UTSW 17 24,435,291 (GRCm39) missense probably damaging 1.00
R1986:Tedc2 UTSW 17 24,435,292 (GRCm39) nonsense probably null
R1986:Tedc2 UTSW 17 24,435,291 (GRCm39) missense probably damaging 1.00
R2026:Tedc2 UTSW 17 24,435,292 (GRCm39) nonsense probably null
R2026:Tedc2 UTSW 17 24,435,291 (GRCm39) missense probably damaging 1.00
R2054:Tedc2 UTSW 17 24,435,292 (GRCm39) nonsense probably null
R2054:Tedc2 UTSW 17 24,435,291 (GRCm39) missense probably damaging 1.00
R2086:Tedc2 UTSW 17 24,436,874 (GRCm39) missense probably damaging 1.00
R2317:Tedc2 UTSW 17 24,435,358 (GRCm39) missense probably benign 0.00
R3705:Tedc2 UTSW 17 24,435,361 (GRCm39) missense probably benign 0.30
R4085:Tedc2 UTSW 17 24,438,813 (GRCm39) missense probably benign 0.01
R4664:Tedc2 UTSW 17 24,439,114 (GRCm39) splice site probably benign
R4676:Tedc2 UTSW 17 24,438,985 (GRCm39) missense probably benign
R4686:Tedc2 UTSW 17 24,436,862 (GRCm39) critical splice donor site probably null
R4762:Tedc2 UTSW 17 24,435,354 (GRCm39) missense probably benign 0.05
R4837:Tedc2 UTSW 17 24,439,567 (GRCm39) missense probably damaging 1.00
R4863:Tedc2 UTSW 17 24,436,910 (GRCm39) missense probably damaging 1.00
R5936:Tedc2 UTSW 17 24,435,315 (GRCm39) missense probably damaging 1.00
R9159:Tedc2 UTSW 17 24,436,705 (GRCm39) missense probably damaging 1.00
R9643:Tedc2 UTSW 17 24,435,328 (GRCm39) missense probably benign
RF031:Tedc2 UTSW 17 24,435,213 (GRCm39) critical splice donor site probably benign
Z1177:Tedc2 UTSW 17 24,439,545 (GRCm39) missense possibly damaging 0.92
Predicted Primers PCR Primer
(F):5'- AGCTACTGCTTCTCCCGAGACTTAC -3'
(R):5'- TGCATACTACGGGCTGCTACACAC -3'

Sequencing Primer
(F):5'- TCCCGAGACTTACCCTGG -3'
(R):5'- ctgcctgcctctgcctc -3'
Posted On 2013-11-18