Incidental Mutation 'R1070:Ugt2b38'
ID 86160
Institutional Source Beutler Lab
Gene Symbol Ugt2b38
Ensembl Gene ENSMUSG00000061906
Gene Name UDP glucuronosyltransferase 2 family, polypeptide B38
Synonyms 9430041C03Rik
MMRRC Submission 039156-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.080) question?
Stock # R1070 (G1)
Quality Score 225
Status Validated
Chromosome 5
Chromosomal Location 87557801-87572062 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 87560232 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Histidine at position 361 (N361H)
Ref Sequence ENSEMBL: ENSMUSP00000072598 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072818]
AlphaFold Q91WH2
Predicted Effect probably damaging
Transcript: ENSMUST00000072818
AA Change: N361H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000072598
Gene: ENSMUSG00000061906
AA Change: N361H

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
Pfam:UDPGT 24 527 4.1e-255 PFAM
Pfam:Glyco_tran_28_C 330 444 1.2e-7 PFAM
Meta Mutation Damage Score 0.8618 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.9%
  • 10x: 97.6%
  • 20x: 95.7%
Validation Efficiency 95% (41/43)
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2ml1 T C 6: 128,520,263 (GRCm39) D1367G probably damaging Het
Actr3b A G 5: 26,053,491 (GRCm39) probably benign Het
Agtr1b A T 3: 20,369,912 (GRCm39) N231K probably benign Het
Bach1 T C 16: 87,517,009 (GRCm39) S517P probably benign Het
Blzf1 A G 1: 164,131,499 (GRCm39) probably benign Het
Bptf G T 11: 106,945,881 (GRCm39) Q2453K possibly damaging Het
Gtf3c3 C T 1: 54,456,937 (GRCm39) A488T probably damaging Het
Heatr4 T C 12: 84,024,841 (GRCm39) T327A possibly damaging Het
Hes1 T C 16: 29,886,101 (GRCm39) I235T probably damaging Het
Hmcn1 T A 1: 150,565,341 (GRCm39) D2262V probably damaging Het
Ifi208 C T 1: 173,510,610 (GRCm39) A255V probably damaging Het
Inhbe T C 10: 127,187,382 (GRCm39) I11M probably benign Het
Ipo9 T C 1: 135,334,281 (GRCm39) E315G possibly damaging Het
Itih1 G T 14: 30,664,413 (GRCm39) probably benign Het
Kcnk2 A G 1: 188,988,960 (GRCm39) probably benign Het
Kdm4c T A 4: 74,291,865 (GRCm39) Y827* probably null Het
Kif5a T C 10: 127,081,275 (GRCm39) T220A probably benign Het
Krt78 A G 15: 101,854,728 (GRCm39) Y1028H possibly damaging Het
Ldc1 T C 4: 130,112,949 (GRCm39) E149G probably benign Het
Mylk4 T C 13: 32,908,801 (GRCm39) D333G probably benign Het
Net1 A T 13: 3,962,930 (GRCm39) S45T probably benign Het
Npat T A 9: 53,483,892 (GRCm39) F1403I probably damaging Het
Or5h25 A G 16: 58,930,182 (GRCm39) S264P probably benign Het
Or5p57 T C 7: 107,665,858 (GRCm39) D49G probably benign Het
Or7a35 C T 10: 78,853,684 (GRCm39) P176L probably damaging Het
Pcif1 T C 2: 164,731,058 (GRCm39) Y404H probably benign Het
Pdzd2 A G 15: 12,390,052 (GRCm39) probably null Het
Rab3a A G 8: 71,209,840 (GRCm39) N40S probably damaging Het
Raf1 T C 6: 115,614,660 (GRCm39) N74D probably benign Het
Rap1gap2 A G 11: 74,327,853 (GRCm39) V139A possibly damaging Het
Rdh12 T C 12: 79,260,522 (GRCm39) L206P probably damaging Het
Rimoc1 C A 15: 4,015,848 (GRCm39) V239F probably benign Het
Sdhb T C 4: 140,698,547 (GRCm39) probably benign Het
Sned1 G A 1: 93,209,376 (GRCm39) V830M possibly damaging Het
Strip1 T C 3: 107,534,724 (GRCm39) E102G possibly damaging Het
Sult2a8 T A 7: 14,147,698 (GRCm39) I198F probably damaging Het
Tars3 T C 7: 65,305,444 (GRCm39) S223P probably damaging Het
Vcam1 C T 3: 115,904,552 (GRCm39) V732M possibly damaging Het
Vmn2r79 T C 7: 86,652,681 (GRCm39) Y458H probably damaging Het
Other mutations in Ugt2b38
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00959:Ugt2b38 APN 5 87,559,682 (GRCm39) missense probably damaging 1.00
IGL02326:Ugt2b38 APN 5 87,571,592 (GRCm39) missense probably damaging 1.00
IGL02537:Ugt2b38 APN 5 87,569,590 (GRCm39) missense possibly damaging 0.91
IGL02543:Ugt2b38 APN 5 87,571,342 (GRCm39) missense probably benign 0.00
IGL02852:Ugt2b38 APN 5 87,559,600 (GRCm39) missense probably benign
IGL03008:Ugt2b38 APN 5 87,560,282 (GRCm39) missense probably benign 0.00
over_easy UTSW 5 87,571,601 (GRCm39) missense probably benign 0.25
R0089:Ugt2b38 UTSW 5 87,568,417 (GRCm39) missense probably benign 0.00
R0647:Ugt2b38 UTSW 5 87,571,328 (GRCm39) missense probably benign 0.00
R0731:Ugt2b38 UTSW 5 87,568,311 (GRCm39) missense probably damaging 1.00
R0837:Ugt2b38 UTSW 5 87,559,632 (GRCm39) missense probably damaging 1.00
R0966:Ugt2b38 UTSW 5 87,560,232 (GRCm39) missense probably damaging 1.00
R0969:Ugt2b38 UTSW 5 87,560,232 (GRCm39) missense probably damaging 1.00
R0970:Ugt2b38 UTSW 5 87,560,232 (GRCm39) missense probably damaging 1.00
R0971:Ugt2b38 UTSW 5 87,560,232 (GRCm39) missense probably damaging 1.00
R1068:Ugt2b38 UTSW 5 87,560,232 (GRCm39) missense probably damaging 1.00
R1071:Ugt2b38 UTSW 5 87,560,232 (GRCm39) missense probably damaging 1.00
R1073:Ugt2b38 UTSW 5 87,560,232 (GRCm39) missense probably damaging 1.00
R1133:Ugt2b38 UTSW 5 87,560,232 (GRCm39) missense probably damaging 1.00
R1134:Ugt2b38 UTSW 5 87,560,232 (GRCm39) missense probably damaging 1.00
R1367:Ugt2b38 UTSW 5 87,571,973 (GRCm39) missense probably benign 0.11
R1383:Ugt2b38 UTSW 5 87,560,232 (GRCm39) missense probably damaging 1.00
R1467:Ugt2b38 UTSW 5 87,560,232 (GRCm39) missense probably damaging 1.00
R1467:Ugt2b38 UTSW 5 87,560,232 (GRCm39) missense probably damaging 1.00
R1565:Ugt2b38 UTSW 5 87,559,773 (GRCm39) missense probably damaging 0.99
R1691:Ugt2b38 UTSW 5 87,571,991 (GRCm39) missense probably benign
R1725:Ugt2b38 UTSW 5 87,559,730 (GRCm39) missense probably damaging 1.00
R1736:Ugt2b38 UTSW 5 87,571,492 (GRCm39) missense probably benign
R2230:Ugt2b38 UTSW 5 87,569,527 (GRCm39) missense probably benign 0.05
R2419:Ugt2b38 UTSW 5 87,571,591 (GRCm39) missense probably damaging 1.00
R2496:Ugt2b38 UTSW 5 87,569,551 (GRCm39) missense probably damaging 1.00
R3196:Ugt2b38 UTSW 5 87,558,078 (GRCm39) missense probably damaging 0.96
R3773:Ugt2b38 UTSW 5 87,571,954 (GRCm39) missense probably damaging 0.99
R5125:Ugt2b38 UTSW 5 87,559,671 (GRCm39) missense probably damaging 1.00
R5224:Ugt2b38 UTSW 5 87,571,601 (GRCm39) missense probably benign 0.25
R5516:Ugt2b38 UTSW 5 87,559,702 (GRCm39) missense probably damaging 1.00
R5765:Ugt2b38 UTSW 5 87,571,954 (GRCm39) missense probably damaging 0.99
R6352:Ugt2b38 UTSW 5 87,571,860 (GRCm39) missense possibly damaging 0.73
R7166:Ugt2b38 UTSW 5 87,558,305 (GRCm39) missense probably damaging 1.00
R7210:Ugt2b38 UTSW 5 87,558,284 (GRCm39) missense probably damaging 0.99
R7291:Ugt2b38 UTSW 5 87,559,754 (GRCm39) missense probably damaging 1.00
R7483:Ugt2b38 UTSW 5 87,571,973 (GRCm39) missense probably damaging 0.96
R7969:Ugt2b38 UTSW 5 87,571,891 (GRCm39) missense probably benign 0.02
R8118:Ugt2b38 UTSW 5 87,571,630 (GRCm39) missense probably damaging 1.00
R8239:Ugt2b38 UTSW 5 87,571,659 (GRCm39) missense probably benign 0.02
R8676:Ugt2b38 UTSW 5 87,559,681 (GRCm39) missense probably benign 0.12
R9178:Ugt2b38 UTSW 5 87,568,396 (GRCm39) missense probably damaging 1.00
R9193:Ugt2b38 UTSW 5 87,571,729 (GRCm39) missense probably benign 0.05
R9566:Ugt2b38 UTSW 5 87,558,209 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTGGCCCCACCATGAGTTACAAAG -3'
(R):5'- GGCACACTCGTTGCTCAGTCTT -3'

Sequencing Primer
(F):5'- CTCTGTCTCAGAGCTAGAAGAATC -3'
(R):5'- cacacacacacacacacac -3'
Posted On 2013-11-18