Incidental Mutation 'IGL01459:Kif15'
ID87928
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Kif15
Ensembl Gene ENSMUSG00000036768
Gene Namekinesin family member 15
SynonymsHKLP2, Knsl7, N-10 kinesin
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.342) question?
Stock #IGL01459
Quality Score
Status
Chromosome9
Chromosomal Location122951046-123018733 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 122975755 bp
ZygosityHeterozygous
Amino Acid Change Glutamic Acid to Glycine at position 189 (E189G)
Ref Sequence ENSEMBL: ENSMUSP00000150932 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000040717] [ENSMUST00000213745] [ENSMUST00000214652] [ENSMUST00000216388] [ENSMUST00000217401]
Predicted Effect probably damaging
Transcript: ENSMUST00000040717
AA Change: E189G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000035490
Gene: ENSMUSG00000036768
AA Change: E189G

DomainStartEndE-ValueType
KISc 24 371 2.86e-179 SMART
Pfam:Kinesin-relat_1 463 551 6.6e-26 PFAM
coiled coil region 579 643 N/A INTRINSIC
coiled coil region 706 1037 N/A INTRINSIC
coiled coil region 1065 1133 N/A INTRINSIC
Pfam:HMMR_C 1265 1387 3.5e-12 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213745
AA Change: E189G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably benign
Transcript: ENSMUST00000214652
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214880
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215176
Predicted Effect probably benign
Transcript: ENSMUST00000216388
Predicted Effect probably damaging
Transcript: ENSMUST00000217401
AA Change: E118G

PolyPhen 2 Score 0.976 (Sensitivity: 0.76; Specificity: 0.96)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atp2a2 A G 5: 122,469,652 S265P probably benign Het
Brwd1 A G 16: 96,047,420 F520L probably damaging Het
Cdh5 A T 8: 104,137,817 D470V probably damaging Het
Cdr2l A G 11: 115,390,552 R41G probably damaging Het
Csrnp1 C T 9: 119,972,958 C345Y probably damaging Het
Dscaml1 T A 9: 45,742,683 Y1419* probably null Het
Entpd3 T C 9: 120,561,941 S420P probably damaging Het
Epb41 A G 4: 131,964,128 probably benign Het
Erg A G 16: 95,361,282 S322P probably damaging Het
Fndc3b T A 3: 27,461,740 H639L probably benign Het
Grwd1 C T 7: 45,830,410 probably null Het
Kbtbd8 A G 6: 95,122,808 N356D probably benign Het
Kif2b T C 11: 91,577,023 K145E possibly damaging Het
Kif5c A G 2: 49,735,557 D613G probably benign Het
Lipe T G 7: 25,383,542 Q457P probably damaging Het
Lrp1b A T 2: 40,860,714 I2946N probably damaging Het
Mtf2 C T 5: 108,080,943 P42S probably damaging Het
Neb A G 2: 52,176,792 S5886P probably damaging Het
Nmu A G 5: 76,358,349 probably null Het
Nup153 T C 13: 46,712,926 E214G possibly damaging Het
Olfr301 A C 7: 86,412,551 N104T probably damaging Het
Olfr792 G A 10: 129,540,541 M1I probably null Het
Paqr3 T C 5: 97,095,937 D306G probably benign Het
Plxna2 A G 1: 194,764,570 D796G probably benign Het
Prkra A G 2: 76,630,436 L306S probably damaging Het
Psg20 T A 7: 18,682,713 E159D probably damaging Het
Ptchd3 G T 11: 121,830,420 V40L probably benign Het
Rfx5 T C 3: 94,957,775 probably benign Het
Rimbp2 A G 5: 128,788,211 probably null Het
Slc22a4 C A 11: 53,986,477 probably null Het
Tars A G 15: 11,391,854 V265A possibly damaging Het
Tatdn2 T A 6: 113,710,031 probably null Het
Tenm4 C T 7: 96,729,385 P399L probably damaging Het
Tmem135 A T 7: 89,151,438 D325E probably damaging Het
Tmprss7 A T 16: 45,663,343 I556N probably benign Het
Tom1l2 C T 11: 60,280,269 G23S probably damaging Het
Ubr2 A G 17: 46,930,509 probably benign Het
Vmn1r197 T C 13: 22,328,071 I54T probably benign Het
Vmn2r116 T C 17: 23,384,929 C43R probably damaging Het
Vps33a A G 5: 123,535,308 L405P probably benign Het
Zfp473 C T 7: 44,739,563 D45N probably damaging Het
Other mutations in Kif15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01577:Kif15 APN 9 122996334 missense probably benign 0.06
IGL01647:Kif15 APN 9 122963471 intron probably benign
IGL01921:Kif15 APN 9 122979504 missense probably damaging 1.00
IGL02040:Kif15 APN 9 123017385 missense probably damaging 0.99
IGL02191:Kif15 APN 9 122975679 missense probably damaging 1.00
IGL02218:Kif15 APN 9 122995827 splice site probably benign
IGL02537:Kif15 APN 9 122993849 missense probably benign 0.08
IGL02814:Kif15 APN 9 123003640 missense possibly damaging 0.83
PIT4480001:Kif15 UTSW 9 123011543 missense probably benign
R0034:Kif15 UTSW 9 122999285 missense possibly damaging 0.47
R0458:Kif15 UTSW 9 123009359 missense probably benign
R0526:Kif15 UTSW 9 122997797 missense probably damaging 0.96
R0533:Kif15 UTSW 9 123009433 unclassified probably benign
R0726:Kif15 UTSW 9 122959928 missense probably benign 0.21
R1580:Kif15 UTSW 9 122959956 missense probably benign 0.22
R1597:Kif15 UTSW 9 122994009 missense probably benign 0.22
R2096:Kif15 UTSW 9 122986187 missense probably damaging 1.00
R3125:Kif15 UTSW 9 122987961 missense probably damaging 0.99
R3176:Kif15 UTSW 9 122987840 splice site probably benign
R4088:Kif15 UTSW 9 122986189 missense probably benign 0.29
R4308:Kif15 UTSW 9 123013982 missense probably benign 0.00
R4597:Kif15 UTSW 9 122993849 missense probably benign 0.08
R4705:Kif15 UTSW 9 122959993 splice site probably null
R4832:Kif15 UTSW 9 123002126 splice site probably null
R5100:Kif15 UTSW 9 122991994 missense probably damaging 0.98
R5126:Kif15 UTSW 9 122975758 missense probably damaging 1.00
R5180:Kif15 UTSW 9 122999210 missense probably damaging 0.99
R5247:Kif15 UTSW 9 122986442 missense possibly damaging 0.65
R5376:Kif15 UTSW 9 122993971 missense probably benign 0.04
R5392:Kif15 UTSW 9 122996295 missense probably damaging 0.99
R5422:Kif15 UTSW 9 122984889 synonymous probably null
R5562:Kif15 UTSW 9 122978016 missense probably damaging 1.00
R5663:Kif15 UTSW 9 122991851 splice site probably null
R5767:Kif15 UTSW 9 123013974 missense possibly damaging 0.78
R5927:Kif15 UTSW 9 123017261 missense probably benign 0.00
R6049:Kif15 UTSW 9 123011622 missense probably damaging 0.98
R6435:Kif15 UTSW 9 122986491 missense probably damaging 1.00
R7040:Kif15 UTSW 9 123011614 missense possibly damaging 0.67
Posted On2013-11-18