Incidental Mutation 'IGL01466:Zfp277'
ID88103
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp277
Ensembl Gene ENSMUSG00000055917
Gene Namezinc finger protein 277
Synonyms2410017E24Rik, NIRF4
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.084) question?
Stock #IGL01466
Quality Score
Status
Chromosome12
Chromosomal Location40315046-40445902 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to A at 40378826 bp
ZygosityHeterozygous
Amino Acid Change Glycine to Valine at position 174 (G174V)
Ref Sequence ENSEMBL: ENSMUSP00000064226 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000069637] [ENSMUST00000069692]
Predicted Effect probably benign
Transcript: ENSMUST00000069637
AA Change: G48V

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000068032
Gene: ENSMUSG00000055917
AA Change: G48V

DomainStartEndE-ValueType
ZnF_C2H2 59 84 4.27e1 SMART
coiled coil region 143 171 N/A INTRINSIC
ZnF_C2H2 174 198 3.85e1 SMART
ZnF_C2H2 225 249 2.24e-3 SMART
low complexity region 280 292 N/A INTRINSIC
ZnF_C2H2 303 326 1.91e1 SMART
ZnF_C2H2 356 382 4.94e0 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000069692
AA Change: G174V

PolyPhen 2 Score 0.240 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000064226
Gene: ENSMUSG00000055917
AA Change: G174V

DomainStartEndE-ValueType
ZnF_C2H2 185 210 4.27e1 SMART
coiled coil region 269 297 N/A INTRINSIC
ZnF_C2H2 300 324 3.85e1 SMART
ZnF_C2H2 351 375 2.24e-3 SMART
low complexity region 406 418 N/A INTRINSIC
ZnF_C2H2 429 452 1.91e1 SMART
ZnF_C2H2 482 508 4.94e0 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit early cellular preplicative senescence in MEFs. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 20 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acr A G 15: 89,573,994 N293D probably benign Het
Ankrd49 A G 9: 14,781,349 L173P probably damaging Het
Ccdc152 A G 15: 3,293,847 probably benign Het
Cdh3 G T 8: 106,536,595 R92L possibly damaging Het
Dnajc10 A T 2: 80,321,287 R137S probably benign Het
Dusp27 T G 1: 166,100,504 D513A probably damaging Het
Htra2 A G 6: 83,054,323 L35P probably damaging Het
Il23r A T 6: 67,426,642 M425K probably benign Het
Nfkb2 G T 19: 46,308,016 R241L probably damaging Het
Nup205 A G 6: 35,199,959 D630G probably benign Het
Olfr344 T A 2: 36,568,742 L48H probably damaging Het
Peli2 T C 14: 48,256,457 Y379H probably damaging Het
Plekhg6 G T 6: 125,372,624 probably benign Het
Samd14 G T 11: 95,023,255 probably benign Het
Setd7 A T 3: 51,521,309 *367R probably null Het
Slc26a8 A G 17: 28,654,948 V355A probably benign Het
Slc46a2 T A 4: 59,911,926 K429* probably null Het
Tspan32 T C 7: 143,014,954 probably benign Het
Unc80 T C 1: 66,622,486 V1690A probably benign Het
Ush2a C A 1: 188,911,622 Q4394K probably benign Het
Other mutations in Zfp277
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01477:Zfp277 APN 12 40320676 missense probably benign 0.00
IGL02081:Zfp277 APN 12 40328796 nonsense probably null
IGL02165:Zfp277 APN 12 40315803 missense possibly damaging 0.75
IGL02613:Zfp277 APN 12 40329515 missense probably damaging 1.00
IGL02688:Zfp277 APN 12 40328688 missense possibly damaging 0.95
IGL02825:Zfp277 APN 12 40317176 missense probably benign 0.06
R0194:Zfp277 UTSW 12 40378877 splice site probably benign
R0226:Zfp277 UTSW 12 40364162 missense possibly damaging 0.67
R0843:Zfp277 UTSW 12 40320600 critical splice donor site probably null
R1263:Zfp277 UTSW 12 40364165 missense probably damaging 0.99
R1584:Zfp277 UTSW 12 40378826 missense probably benign 0.12
R1609:Zfp277 UTSW 12 40328720 missense probably damaging 0.99
R1644:Zfp277 UTSW 12 40329610 splice site probably null
R1789:Zfp277 UTSW 12 40364085 missense probably benign 0.00
R1882:Zfp277 UTSW 12 40445746 missense probably benign 0.03
R2011:Zfp277 UTSW 12 40317218 nonsense probably null
R4884:Zfp277 UTSW 12 40363153 missense probably damaging 0.97
R4976:Zfp277 UTSW 12 40328688 missense possibly damaging 0.95
R5119:Zfp277 UTSW 12 40328688 missense possibly damaging 0.95
R5532:Zfp277 UTSW 12 40335309 missense probably damaging 1.00
R6340:Zfp277 UTSW 12 40318549 missense possibly damaging 0.57
R7191:Zfp277 UTSW 12 40329562 missense probably damaging 1.00
R7378:Zfp277 UTSW 12 40315853 missense possibly damaging 0.94
R7446:Zfp277 UTSW 12 40328730 missense probably damaging 1.00
Posted On2013-11-18